- Hot Results
- Quick Search
- Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
- Data Summary
Gene Report
Approved Symbol | ID2 |
---|---|
Symbol Alias | GIG8, bHLHb26 |
Approved Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
Name Alias | cell growth-inhibiting gene 8 |
Location | 2p25 |
Position | chr2:8818975-8824583, + |
External Links |
HGNC: 5361 Entrez Gene: 3398 Ensembl: ENSG00000115738 UCSC: uc002qza.2 |
No. of Studies | 1 (significant: 0; non-significant: 1; trend: 0) |
Source | Literature-origin; Mapped by significant region |
Reference | Statistical Values/Author Comments | Result of Statistical Analysis |
---|---|---|
Ribases M, 2009(a) | No available data. No significant association with ADHD was found. | Non-significant |
Region Name | Position | No. of Studies (significant/non-significant/trend) |
---|---|---|
2p25.1 | chr2:7100000-12200000 | 2 (1/0/1) |
GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)
GO terms by database search (count: 51)
ID | Name | No. of Genes in ADHDgene | Brief Description |
---|---|---|---|
hsa04350 | TGF-beta signaling pathway | 10 | The transforming growth factor-beta (TGF-beta) family member...... The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins. More... |
Region: chr2:8818975..8824583 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014