ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ID2
Symbol Alias	GIG8, bHLHb26
Approved Name	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Name Alias	cell growth-inhibiting gene 8
Location	2p25
Position	chr2:8818975-8824583, +
External Links	HGNC: 5361 Entrez Gene: 3398 Ensembl: ENSG00000115738 UCSC: uc002qza.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2009(a)	No available data. No significant association with ADHD was found.	Non-significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2p25.1	chr2:7100000-12200000	2 (1/0/1)

Gene related GO terms (count: 51)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 51)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0090398	cellular senescence	Biological Process		3
GO:0071931	positive regulation of transcription involved in G1/S phase of mitotic cell cycle	Biological Process	IC[16311606]	1
GO:2000178	negative regulation of neural precursor cell proliferation	Biological Process		1
GO:2000045	regulation of G1/S transition of mitotic cell cycle	Biological Process	IMP[16311606]	1
GO:0061031	endodermal digestive tract morphogenesis	Biological Process		1
GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	Biological Process		2
GO:0071285	cellular response to lithium ion	Biological Process		3
GO:0071158	positive regulation of cell cycle arrest	Biological Process		4
GO:0014003	oligodendrocyte development	Biological Process		3
GO:0010629	negative regulation of gene expression	Biological Process		13
GO:0010628	positive regulation of gene expression	Biological Process		28
GO:0009649	entrainment of circadian clock	Biological Process		2
GO:0043234	protein complex	Cellular Component		45
GO:0033598	mammary gland epithelial cell proliferation	Biological Process		3
GO:0021772	olfactory bulb development	Biological Process		1
GO:0019216	regulation of lipid metabolic process	Biological Process		2
GO:0044325	ion channel binding	Molecular Function	IPI[16311606]	15
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	Biological Process	IDA[14627819]	6
GO:0043392	negative regulation of DNA binding	Biological Process		5
GO:0043353	enucleate erythrocyte differentiation	Biological Process		1
GO:0045651	positive regulation of macrophage differentiation	Biological Process		1
GO:0045648	positive regulation of erythrocyte differentiation	Biological Process		3
GO:0045600	positive regulation of fat cell differentiation	Biological Process		4
GO:0045578	negative regulation of B cell differentiation	Biological Process		2
GO:0045777	positive regulation of blood pressure	Biological Process		6
GO:0045787	positive regulation of cell cycle	Biological Process		7
GO:0045665	negative regulation of neuron differentiation	Biological Process		13
GO:0045668	negative regulation of osteoblast differentiation	Biological Process		6
GO:0046983	protein dimerization activity	Molecular Function		26
GO:0048469	cell maturation	Biological Process		6
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[14627819]	64
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process		80
GO:0048661	positive regulation of smooth muscle cell proliferation	Biological Process		5
GO:0048663	neuron fate commitment	Biological Process		2
GO:0048541	Peyer's patch development	Biological Process		3
GO:0048557	embryonic digestive tract morphogenesis	Biological Process		7
GO:0060612	adipose tissue development	Biological Process		7
GO:0060749	mammary gland alveolus development	Biological Process		5
GO:0048711	positive regulation of astrocyte differentiation	Biological Process		4
GO:0048715	negative regulation of oligodendrocyte differentiation	Biological Process		3
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0000785	chromatin	Cellular Component		13
GO:0001656	metanephros development	Biological Process		7
GO:0001779	natural killer cell differentiation	Biological Process		2
GO:0003166	bundle of His development	Biological Process		1
GO:0005515	protein binding	Molecular Function	IPI[10915743]	910
GO:0005634	nucleus	Cellular Component		770
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component	IDA[16311606]	690
GO:0005829	cytosol	Cellular Component	IDA[16311606]	447
GO:0007275	multicellular organismal development	Biological Process	TAS[1741406]	71

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04350	TGF-beta signaling pathway	10	The transforming growth factor-beta (TGF-beta) family member...... The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins. More...

Genes shared at least 5 GO terms with ID2 (count: 78)

Gene Symbol	Pathway Count	Pathway List
MEN1	11	protein complex; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin; protein binding; nucleus; nucleolus; cytoplasm; cytosol;
TFAP2A	9	positive regulation of gene expression; protein dimerization activity; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; nucleolus; cytoplasm;
MAPK1	8	protein complex; mammary gland epithelial cell proliferation; positive regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus; cytoplasm; cytosol;
HES1	8	cell maturation; negative regulation of transcription, DNA-dependent; positive regulation of astrocyte differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytoplasm;
KAT5	8	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin; protein binding; nucleus; nucleolus; cytosol;
HEY2	7	negative regulation of gene expression; protein dimerization activity; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytoplasm;
HINFP	7	negative regulation of gene expression; positive regulation of gene expression; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus;
MED1	7	positive regulation of gene expression; negative regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; nucleolus;
KDM1A	7	negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of DNA binding; positive regulation of erythrocyte differentiation; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus;
FLCN	6	negative regulation of gene expression; positive regulation of gene expression; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytoplasm;
VEGFA	6	positive regulation of gene expression; cell maturation; mammary gland alveolus development; negative regulation of transcription from RNA polymerase II promoter; protein binding; cytoplasm;
HOXA11	6	protein complex; positive regulation of transcription, DNA-dependent; metanephros development; nucleolus; cytoplasm; multicellular organismal development;
MALT1	6	protein complex; protein binding; nucleus; nucleolus; cytoplasm; cytosol;
STRN3	6	protein complex; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytoplasm;
DAXX	6	negative regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus; cytoplasm; cytosol;
GSK3B	6	negative regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus; cytoplasm; cytosol;
NIPBL	6	negative regulation of transcription, DNA-dependent; embryonic digestive tract morphogenesis; negative regulation of transcription from RNA polymerase II promoter; metanephros development; protein binding; nucleus;
PDCD4	6	negative regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus; cytoplasm; cytosol;
RBPJ	6	negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; nucleolus; cytoplasm;
RELA	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein binding; nucleus; cytoplasm; cytosol;
SNW1	6	negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin; protein binding; nucleus; nucleolus;
HNF1B	6	positive regulation of transcription, DNA-dependent; embryonic digestive tract morphogenesis; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; nucleolus;
IRF7	6	positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytoplasm; cytosol;
FOXF1	5	epithelial cell differentiation involved in mammary gland alveolus development; positive regulation of transcription, DNA-dependent; embryonic digestive tract morphogenesis; negative regulation of transcription from RNA polymerase II promoter; nucleus;
GATA6	5	positive regulation of cell cycle arrest; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus;
RRP8	5	positive regulation of cell cycle arrest; protein binding; nucleus; nucleolus; cytoplasm;
CRYAB	5	negative regulation of gene expression; protein binding; nucleus; cytoplasm; cytosol;
PGR	5	negative regulation of gene expression; protein binding; nucleus; nucleolus; cytoplasm;
PPM1F	5	positive regulation of gene expression; protein complex; negative regulation of transcription, DNA-dependent; protein binding; cytosol;
SLC6A4	5	positive regulation of gene expression; positive regulation of cell cycle; negative regulation of neuron differentiation; protein binding; cytosol;
PER1	5	entrainment of circadian clock; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; nucleus; cytoplasm;
ILK	5	protein complex; positive regulation of transcription, DNA-dependent; protein binding; cytoplasm; cytosol;
SREBF1	5	protein complex; protein dimerization activity; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus;
STAP1	5	protein complex; protein binding; nucleus; nucleolus; cytoplasm;
CCND1	5	mammary gland epithelial cell proliferation; mammary gland alveolus development; protein binding; nucleus; cytosol;
HABP4	5	negative regulation of DNA binding; protein binding; nucleus; cytoplasm; cytosol;
RSF1	5	negative regulation of DNA binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein binding; nucleus;
DACT1	5	positive regulation of fat cell differentiation; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytoplasm;
LRP5	5	positive regulation of fat cell differentiation; negative regulation of osteoblast differentiation; positive regulation of transcription, DNA-dependent; adipose tissue development; protein binding;
ZBTB16	5	positive regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein binding; nucleus;
NCF2	5	positive regulation of blood pressure; protein binding; nucleolus; cytoplasm; cytosol;
FOXG1	5	positive regulation of cell cycle; negative regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; protein binding; nucleus;
APBB1	5	negative regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; protein binding; nucleus; cytoplasm;
CDK5RAP2	5	negative regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; protein binding; cytoplasm; cytosol;
PRPF19	5	negative regulation of neuron differentiation; positive regulation of astrocyte differentiation; protein binding; nucleus; cytoplasm;
NPAS3	5	protein dimerization activity; positive regulation of transcription, DNA-dependent; nucleus; nucleolus; cytoplasm;
POU2F3	5	protein dimerization activity; protein binding; nucleus; nucleolus; cytoplasm;
WWOX	5	protein dimerization activity; protein binding; nucleus; cytoplasm; cytosol;
ATXN1	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus; cytoplasm;
BCLAF1	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus; cytoplasm;
HMGA1	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein binding; nucleus; cytosol;
HSPA8	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus; cytosol;
RREB1	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; nucleus; cytoplasm; multicellular organismal development;
WWP1	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; cytoplasm; cytosol;
XRCC5	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus; cytoplasm;
IRF8	5	positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytosol;
RAN	5	positive regulation of transcription, DNA-dependent; chromatin; protein binding; cytoplasm; cytosol;
IKZF1	5	Peyer's patch development; negative regulation of transcription from RNA polymerase II promoter; natural killer cell differentiation; nucleus; cytoplasm;
NEDD4L	5	negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytoplasm; cytosol;
PDE2A	5	negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytoplasm; cytosol;
TCF25	5	negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; nucleolus; cytoplasm;
XPO1	5	negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleolus; cytoplasm; cytosol;
ARRB1	5	chromatin; protein binding; nucleus; cytoplasm; cytosol;
AIP	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
ALKBH8	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
BAIAP2	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
CEP164	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
CEP57	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
DCPS	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
FLII	5	protein binding; nucleus; nucleolus; cytoplasm; multicellular organismal development;
IARS	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
NUMA1	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
PAFAH1B1	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
PPP1CA	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
RFWD2	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
SART1	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
STXBP3	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
ZFR	5	protein binding; nucleus; nucleolus; cytoplasm; multicellular organismal development;

Genes shared at least 2 KEGG pathways with ID2 (count: 0)

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Region: chr2:8818975..8824583 View in gBrowse