ADHDgene Database

Gene Report

Basic Info

Approved Symbol	LIPF
Symbol Alias	HGL, HLAL
Approved Name	lipase, gastric
Location	10q23
Position	chr10:90424094-90438572, +
External Links	HGNC: 6622 Entrez Gene: 8513 Ensembl: ENSG00000182333 UCSC: uc001kfg.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49
GO:0004091	carboxylesterase activity	Molecular Function		40

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016042	lipid catabolic process	Biological Process		32
GO:0050253	retinyl-palmitate esterase activity	Molecular Function		9
GO:0005575	cellular_component	Cellular Component		98
GO:0005576	extracellular region	Cellular Component		240
GO:0006641	triglyceride metabolic process	Biological Process	NAS[3304425]	8
GO:0008289	lipid binding	Molecular Function	NAS[2753032]	23
GO:0004806	triglyceride lipase activity	Molecular Function	TAS[3304425]	10

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00561	Glycerolipid metabolism	15
hsa04975	Fat digestion and absorption	19	Fat is an important energy source from food. More than 95% o...... Fat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, dietary TAG is hydrolyzed to fatty acids (FA) and monoacylglycerols (MAG) by pancreatic lipase. These products are then emulsified with the help of phospholipids (PL) and bile acids (BA) present in bile to form micelles. Free FAs and MAGs are taken up by the enterocyte where they are rapidly resynthesized in endoplasmic reticulum (ER) to form TAG. PLs from the diet as well as bile - mainly LPA - too are absorbed by the enterocyte and are acylated to form phosphatidic acid (PA), which is also converted into TAG. Absorbed cholesterol (CL) is acylated to cholesterol esters (CE). Within the ER, TAG joins CE and apolipoprotein B (ApoB) to form chylomicrons that enter circulation through the lymph. More...

Genes shared at least 5 GO terms with LIPF (count: 4)

Gene Symbol	Pathway Count	Pathway List
PNLIP	6	lipase activity; lipid catabolic process; retinyl-palmitate esterase activity; extracellular region; carboxylesterase activity; triglyceride lipase activity;
PNLIPRP2	6	lipase activity; retinyl-palmitate esterase activity; extracellular region; triglyceride metabolic process; carboxylesterase activity; triglyceride lipase activity;
APOC2	5	lipase activity; lipid catabolic process; extracellular region; lipid binding; carboxylesterase activity;
LPL	5	lipase activity; extracellular region; triglyceride metabolic process; carboxylesterase activity; triglyceride lipase activity;

Genes shared at least 2 KEGG pathways with LIPF (count: 22)

Gene Symbol	Pathway Count	Pathway List
DGAT2	3	Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
PNLIP	3	Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
PNLIPRP1	3	Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
PNLIPRP2	3	Metabolic pathways; Glycerolipid metabolism; Fat digestion and absorption;
ALDH3A2	2	Metabolic pathways; Glycerolipid metabolism;
DAK	2	Metabolic pathways; Glycerolipid metabolism;
DGKH	2	Metabolic pathways; Glycerolipid metabolism;
GPAT2	2	Metabolic pathways; Glycerolipid metabolism;
LIPG	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT1	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT2	2	Metabolic pathways; Glycerolipid metabolism;
MGLL	2	Metabolic pathways; Glycerolipid metabolism;
PLA2G10	2	Metabolic pathways; Fat digestion and absorption;
PLA2G1B	2	Metabolic pathways; Fat digestion and absorption;
PLA2G2A	2	Metabolic pathways; Fat digestion and absorption;
PLA2G2D	2	Metabolic pathways; Fat digestion and absorption;
PLA2G2E	2	Metabolic pathways; Fat digestion and absorption;
PLA2G3	2	Metabolic pathways; Fat digestion and absorption;
PLA2G4B	2	Metabolic pathways; Fat digestion and absorption;
PLA2G5	2	Metabolic pathways; Fat digestion and absorption;
PLA2G6	2	Metabolic pathways; Fat digestion and absorption;
PNPLA3	2	Metabolic pathways; Glycerolipid metabolism;

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Region: chr10:90424094..90438572 View in gBrowse