ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MGLL
Symbol Alias	HU-K5, MGL
Approved Name	monoglyceride lipase
Location	3p13-q13.33
Position	chr3:127407909-127542051, -
External Links	HGNC: 17038 Entrez Gene: 11343 Ensembl: ENSG00000074416 UCSC: uc003ejx.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004091	carboxylesterase activity	Molecular Function		40
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006633	fatty acid biosynthetic process	Biological Process		16
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0005886	plasma membrane	Cellular Component		772
GO:0006629	lipid metabolic process	Biological Process		51
GO:0004622	lysophospholipase activity	Molecular Function	TAS[9495531]	5
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0030168	platelet activation	Biological Process		38
GO:0019433	triglyceride catabolic process	Biological Process		7
GO:0019369	arachidonic acid metabolic process	Biological Process		6
GO:0009966	regulation of signal transduction	Biological Process		4
GO:0008289	lipid binding	Molecular Function		23
GO:0007596	blood coagulation	Biological Process		83
GO:0006954	inflammatory response	Biological Process	TAS[9495531]	51
GO:0050727	regulation of inflammatory response	Biological Process		8
GO:0047372	acylglycerol lipase activity	Molecular Function		2
GO:0046474	glycerophospholipid biosynthetic process	Biological Process		30
GO:0046464	acylglycerol catabolic process	Biological Process		1
GO:0045202	synapse	Cellular Component		31
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0042803	protein homodimerization activity	Molecular Function	IPI[19957260]	113
GO:0036155	acylglycerol acyl-chain remodeling	Biological Process		3
GO:0051930	regulation of sensory perception of pain	Biological Process		4
GO:0060292	long term synaptic depression	Biological Process		3
GO:2000124	regulation of endocannabinoid signaling pathway	Biological Process		1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00561	Glycerolipid metabolism	15

Genes shared at least 5 GO terms with MGLL (count: 31)

Gene Symbol	Pathway Count	Pathway List
LPL	8	fatty acid biosynthetic process; phospholipid metabolic process; plasma membrane; lipid metabolic process; carboxylesterase activity; triglyceride catabolic process; lipase activity; small molecule metabolic process;
PLA2G4B	8	phospholipid metabolic process; lysophospholipase activity; carboxylesterase activity; arachidonic acid metabolic process; lipase activity; inflammatory response; glycerophospholipid biosynthetic process; small molecule metabolic process;
PLA2G4C	8	phospholipid metabolic process; endoplasmic reticulum membrane; carboxylesterase activity; arachidonic acid metabolic process; lipase activity; inflammatory response; glycerophospholipid biosynthetic process; small molecule metabolic process;
PNPLA3	8	phospholipid metabolic process; endoplasmic reticulum membrane; carboxylesterase activity; triglyceride catabolic process; lipase activity; glycerophospholipid biosynthetic process; small molecule metabolic process; acylglycerol acyl-chain remodeling;
PNPLA8	8	phospholipid metabolic process; lysophospholipase activity; endoplasmic reticulum membrane; carboxylesterase activity; arachidonic acid metabolic process; lipase activity; glycerophospholipid biosynthetic process; small molecule metabolic process;
ACHE	7	phospholipid metabolic process; plasma membrane; carboxylesterase activity; glycerophospholipid biosynthetic process; synapse; small molecule metabolic process; protein homodimerization activity;
PLA2G1B	6	fatty acid biosynthetic process; phospholipid metabolic process; carboxylesterase activity; lipase activity; glycerophospholipid biosynthetic process; small molecule metabolic process;
DGAT2	6	phospholipid metabolic process; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process; small molecule metabolic process; protein homodimerization activity; acylglycerol acyl-chain remodeling;
PIK3CG	6	phospholipid metabolic process; plasma membrane; platelet activation; blood coagulation; inflammatory response; small molecule metabolic process;
PLA2G10	6	phospholipid metabolic process; carboxylesterase activity; arachidonic acid metabolic process; lipase activity; glycerophospholipid biosynthetic process; small molecule metabolic process;
PLA2G2A	6	phospholipid metabolic process; endoplasmic reticulum membrane; carboxylesterase activity; lipase activity; glycerophospholipid biosynthetic process; small molecule metabolic process;
PLA2G2D	6	phospholipid metabolic process; carboxylesterase activity; lipase activity; inflammatory response; glycerophospholipid biosynthetic process; small molecule metabolic process;
PLA2G2E	6	phospholipid metabolic process; carboxylesterase activity; lipase activity; inflammatory response; glycerophospholipid biosynthetic process; small molecule metabolic process;
PLA2G3	6	phospholipid metabolic process; plasma membrane; carboxylesterase activity; lipase activity; glycerophospholipid biosynthetic process; small molecule metabolic process;
PLA2G5	6	phospholipid metabolic process; plasma membrane; carboxylesterase activity; lipase activity; glycerophospholipid biosynthetic process; small molecule metabolic process;
PLD2	6	phospholipid metabolic process; plasma membrane; endoplasmic reticulum membrane; lipase activity; glycerophospholipid biosynthetic process; small molecule metabolic process;
ADRA2A	6	plasma membrane; platelet activation; blood coagulation; synapse; small molecule metabolic process; protein homodimerization activity;
ADRA2C	6	plasma membrane; platelet activation; blood coagulation; small molecule metabolic process; protein homodimerization activity; regulation of sensory perception of pain;
APOC2	6	lipid metabolic process; carboxylesterase activity; lipase activity; lipid binding; small molecule metabolic process; protein homodimerization activity;
CDIPT	5	phospholipid metabolic process; plasma membrane; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;
CHKA	5	phospholipid metabolic process; lipid metabolic process; glycerophospholipid biosynthetic process; small molecule metabolic process; protein homodimerization activity;
PEMT	5	phospholipid metabolic process; lipid metabolic process; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;
PIK3R1	5	phospholipid metabolic process; plasma membrane; platelet activation; blood coagulation; small molecule metabolic process;
PLA2G6	5	phospholipid metabolic process; carboxylesterase activity; lipase activity; glycerophospholipid biosynthetic process; small molecule metabolic process;
PLD1	5	phospholipid metabolic process; endoplasmic reticulum membrane; lipase activity; glycerophospholipid biosynthetic process; small molecule metabolic process;
PLD3	5	phospholipid metabolic process; endoplasmic reticulum membrane; lipase activity; glycerophospholipid biosynthetic process; small molecule metabolic process;
APOA1	5	plasma membrane; lipid metabolic process; platelet activation; blood coagulation; small molecule metabolic process;
ITPR2	5	plasma membrane; endoplasmic reticulum membrane; platelet activation; blood coagulation; small molecule metabolic process;
RASGRP2	5	plasma membrane; platelet activation; lipid binding; blood coagulation; synapse;
LIPE	5	lipid metabolic process; carboxylesterase activity; triglyceride catabolic process; lipase activity; small molecule metabolic process;
PNLIPRP2	5	lipid metabolic process; carboxylesterase activity; lipase activity; acylglycerol lipase activity; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with MGLL (count: 13)

Gene Symbol	Pathway Count	Pathway List
ALDH3A2	2	Metabolic pathways; Glycerolipid metabolism;
DAK	2	Metabolic pathways; Glycerolipid metabolism;
DGAT2	2	Metabolic pathways; Glycerolipid metabolism;
DGKH	2	Metabolic pathways; Glycerolipid metabolism;
GPAT2	2	Metabolic pathways; Glycerolipid metabolism;
LIPF	2	Metabolic pathways; Glycerolipid metabolism;
LIPG	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT1	2	Metabolic pathways; Glycerolipid metabolism;
MBOAT2	2	Metabolic pathways; Glycerolipid metabolism;
PNLIP	2	Metabolic pathways; Glycerolipid metabolism;
PNLIPRP1	2	Metabolic pathways; Glycerolipid metabolism;
PNLIPRP2	2	Metabolic pathways; Glycerolipid metabolism;
PNPLA3	2	Metabolic pathways; Glycerolipid metabolism;

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Region: chr3:127407909..127542051 View in gBrowse