ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SMNDC1
Symbol Alias	SPF30, SMNR
Approved Name	survival motor neuron domain containing 1
Name Alias	splicing factor 30, survival of motor neuron-related
Location	10q23
Position	chr10:112052798-112064709, -
External Links	HGNC: 16900 Entrez Gene: 10285 Ensembl: ENSG00000119953 UCSC: uc001kzc.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component		51

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016607	nuclear speck	Cellular Component		34
GO:0015030	Cajal body	Cellular Component		11
GO:0008380	RNA splicing	Biological Process	TAS[9731529]	65
GO:0006917	induction of apoptosis	Biological Process	TAS[9817934]	31
GO:0006915	apoptotic process	Biological Process		111
GO:0006397	mRNA processing	Biological Process		50
GO:0005737	cytoplasm	Cellular Component		690
GO:0005634	nucleus	Cellular Component	TAS[9817934]	770
GO:0005515	protein binding	Molecular Function	IPI[15494309]	910
GO:0003723	RNA binding	Molecular Function		104
GO:0000375	RNA splicing, via transesterification reactions	Biological Process	TAS[9731529]	11

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with SMNDC1 (count: 40)

Gene Symbol	Pathway Count	Pathway List
EFTUD2	8	nuclear speck; Cajal body; RNA splicing; mRNA processing; cytoplasm; spliceosomal complex; nucleus; protein binding;
U2AF1	8	nuclear speck; Cajal body; RNA splicing; mRNA processing; spliceosomal complex; nucleus; protein binding; RNA binding;
PRPF4	7	nuclear speck; Cajal body; RNA splicing; spliceosomal complex; nucleus; protein binding; RNA splicing, via transesterification reactions;
PRPF6	7	nuclear speck; RNA splicing; spliceosomal complex; nucleus; protein binding; RNA binding; RNA splicing, via transesterification reactions;
PRPF8	7	nuclear speck; RNA splicing; mRNA processing; spliceosomal complex; protein binding; RNA binding; RNA splicing, via transesterification reactions;
RBM4	7	nuclear speck; RNA splicing; mRNA processing; cytoplasm; nucleus; protein binding; RNA binding;
SF3A3	7	nuclear speck; RNA splicing; mRNA processing; spliceosomal complex; nucleus; protein binding; RNA splicing, via transesterification reactions;
HNRNPA2B1	7	RNA splicing; mRNA processing; cytoplasm; spliceosomal complex; nucleus; protein binding; RNA binding;
HNRNPA1	6	RNA splicing; mRNA processing; cytoplasm; spliceosomal complex; nucleus; RNA binding;
RBFOX1	6	RNA splicing; mRNA processing; cytoplasm; nucleus; protein binding; RNA binding;
SF3A1	6	RNA splicing; mRNA processing; spliceosomal complex; nucleus; protein binding; RNA binding;
SF3B4	6	RNA splicing; mRNA processing; spliceosomal complex; protein binding; RNA binding; RNA splicing, via transesterification reactions;
APBB1	5	nuclear speck; apoptotic process; cytoplasm; nucleus; protein binding;
CD2BP2	5	nuclear speck; RNA splicing; cytoplasm; nucleus; protein binding;
CDK12	5	nuclear speck; RNA splicing; mRNA processing; nucleus; protein binding;
NEK6	5	nuclear speck; apoptotic process; cytoplasm; nucleus; protein binding;
NSRP1	5	nuclear speck; RNA splicing; mRNA processing; nucleus; protein binding;
PRPF18	5	nuclear speck; RNA splicing; mRNA processing; spliceosomal complex; nucleus;
PSPC1	5	nuclear speck; cytoplasm; nucleus; protein binding; RNA binding;
SLU7	5	nuclear speck; cytoplasm; spliceosomal complex; nucleus; RNA splicing, via transesterification reactions;
BCAS2	5	RNA splicing; mRNA processing; spliceosomal complex; protein binding; RNA splicing, via transesterification reactions;
CPSF7	5	RNA splicing; mRNA processing; nucleus; protein binding; RNA binding;
DDX23	5	RNA splicing; spliceosomal complex; nucleus; protein binding; RNA splicing, via transesterification reactions;
DHX8	5	RNA splicing; spliceosomal complex; nucleus; protein binding; RNA binding;
FUS	5	RNA splicing; cytoplasm; nucleus; protein binding; RNA binding;
HNRNPH1	5	RNA splicing; cytoplasm; nucleus; protein binding; RNA binding;
HSPA8	5	RNA splicing; mRNA processing; spliceosomal complex; nucleus; protein binding;
LSM4	5	RNA splicing; mRNA processing; spliceosomal complex; protein binding; RNA binding;
NCBP1	5	RNA splicing; mRNA processing; nucleus; protein binding; RNA binding;
SCAF8	5	RNA splicing; mRNA processing; spliceosomal complex; nucleus; RNA binding;
SNRPG	5	RNA splicing; mRNA processing; spliceosomal complex; protein binding; RNA binding;
TARDBP	5	RNA splicing; mRNA processing; nucleus; protein binding; RNA binding;
U2AF2	5	RNA splicing; mRNA processing; spliceosomal complex; protein binding; RNA binding;
ZMAT5	5	RNA splicing; mRNA processing; cytoplasm; spliceosomal complex; nucleus;
BNIP3	5	induction of apoptosis; apoptotic process; cytoplasm; nucleus; protein binding;
DAXX	5	induction of apoptosis; apoptotic process; cytoplasm; nucleus; protein binding;
MAPK1	5	induction of apoptosis; apoptotic process; cytoplasm; nucleus; protein binding;
WWOX	5	induction of apoptosis; apoptotic process; cytoplasm; nucleus; protein binding;
PDCD4	5	apoptotic process; cytoplasm; nucleus; protein binding; RNA binding;
CELF1	5	mRNA processing; cytoplasm; nucleus; protein binding; RNA binding;

Genes shared at least 2 KEGG pathways with SMNDC1 (count: 0)

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Region: chr10:112052798..112064709 View in gBrowse