ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	WWOX
Symbol Alias	FOR, WOX1, SDR41C1
Approved Name	WW domain containing oxidoreductase
Previous Name	WW domain-containing oxidoreductase
Name Alias	short chain dehydrogenase/reductase family 41C, member 1
Location	16q23.3-q24.1
Position	chr16:78133551-79246564, +
External Links	HGNC: 12799 Entrez Gene: 51741 Ensembl: ENSG00000186153 UCSC: uc002ffk.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 25)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0055114	oxidation-reduction process	Biological Process	TAS[10786676]	15
GO:0050662	coenzyme binding	Molecular Function	TAS[10786676]	3
GO:0048705	skeletal system morphogenesis	Biological Process		4
GO:0048037	cofactor binding	Molecular Function	TAS[10786676]	2
GO:0046983	protein dimerization activity	Molecular Function	TAS[10786676]	26
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0043065	positive regulation of apoptotic process	Biological Process		34
GO:0030178	negative regulation of Wnt receptor signaling pathway	Biological Process	IDA[19465938]	8
GO:0071560	cellular response to transforming growth factor beta stimulus	Biological Process	IDA[19366691]	9
GO:0005737	cytoplasm	Cellular Component	IDA[19465938]; TAS[10786676]	690
GO:0005739	mitochondrion	Cellular Component		183
GO:0005794	Golgi apparatus	Cellular Component	IDA[15064722]	157
GO:0005829	cytosol	Cellular Component	IDA[19366691]	447
GO:0000166	nucleotide binding	Molecular Function		73
GO:0001649	osteoblast differentiation	Biological Process		9
GO:0005515	protein binding	Molecular Function	IPI[16061658]	910
GO:0005634	nucleus	Cellular Component	IDA[19366691]	770
GO:0008202	steroid metabolic process	Biological Process	TAS[10786676]	14
GO:0016055	Wnt receptor signaling pathway	Biological Process		20
GO:0016491	oxidoreductase activity	Molecular Function	NAS[10861292]; TAS[10786676]	21
GO:0019899	enzyme binding	Molecular Function	IPI[19366691]	47
GO:0005886	plasma membrane	Cellular Component	IDA[19366691]	772
GO:0005902	microvillus	Cellular Component	IDA[19366691]	8
GO:0006915	apoptotic process	Biological Process		111
GO:0006917	induction of apoptosis	Biological Process		31

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with WWOX (count: 84)

Gene Symbol	Pathway Count	Pathway List
SNCA	9	oxidation-reduction process; cytoplasm; mitochondrion; Golgi apparatus; cytosol; protein binding; nucleus; oxidoreductase activity; plasma membrane;
PRKD1	8	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; Golgi apparatus; cytosol; protein binding; nucleus; plasma membrane; apoptotic process;
MAPK1	8	cytoplasm; mitochondrion; Golgi apparatus; cytosol; protein binding; nucleus; apoptotic process; induction of apoptosis;
MAPK3	7	positive regulation of transcription from RNA polymerase II promoter; mitochondrion; Golgi apparatus; cytosol; protein binding; nucleus; apoptotic process;
APC	7	positive regulation of apoptotic process; cytoplasm; cytosol; protein binding; nucleus; plasma membrane; apoptotic process;
PMAIP1	7	positive regulation of apoptotic process; mitochondrion; cytosol; protein binding; nucleus; apoptotic process; induction of apoptosis;
PYCARD	7	positive regulation of apoptotic process; cytoplasm; mitochondrion; cytosol; protein binding; nucleus; induction of apoptosis;
PDE2A	7	cellular response to transforming growth factor beta stimulus; cytoplasm; Golgi apparatus; cytosol; protein binding; nucleus; plasma membrane;
AIFM3	7	cytoplasm; mitochondrion; cytosol; nucleus; oxidoreductase activity; plasma membrane; induction of apoptosis;
CRYAB	7	cytoplasm; mitochondrion; Golgi apparatus; cytosol; protein binding; nucleus; plasma membrane;
DAXX	7	cytoplasm; cytosol; protein binding; nucleus; enzyme binding; apoptotic process; induction of apoptosis;
PERP	7	cytoplasm; mitochondrion; Golgi apparatus; nucleus; plasma membrane; apoptotic process; induction of apoptosis;
NOX4	6	oxidation-reduction process; positive regulation of apoptotic process; cellular response to transforming growth factor beta stimulus; mitochondrion; nucleotide binding; nucleus;
TGFBR1	6	skeletal system morphogenesis; cellular response to transforming growth factor beta stimulus; protein binding; plasma membrane; apoptotic process; induction of apoptosis;
TFAP2A	6	protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; Golgi apparatus; protein binding; nucleus;
AATF	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; Golgi apparatus; protein binding; nucleus; apoptotic process;
ARRB1	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; cytosol; protein binding; nucleus; plasma membrane;
FLCN	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of apoptotic process; cytoplasm; protein binding; nucleus; plasma membrane;
GSK3B	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; cytosol; protein binding; nucleus; plasma membrane;
MAPK7	6	positive regulation of transcription from RNA polymerase II promoter; cellular response to transforming growth factor beta stimulus; cytosol; protein binding; nucleus; apoptotic process;
MEN1	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of apoptotic process; cytoplasm; cytosol; protein binding; nucleus;
NCK1	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; cytosol; protein binding; nucleus; plasma membrane;
STRN3	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; Golgi apparatus; protein binding; nucleus; plasma membrane;
APBB1	6	positive regulation of apoptotic process; cytoplasm; protein binding; nucleus; plasma membrane; apoptotic process;
BAD	6	positive regulation of apoptotic process; mitochondrion; cytosol; protein binding; apoptotic process; induction of apoptosis;
BNIP3	6	cytoplasm; mitochondrion; protein binding; nucleus; apoptotic process; induction of apoptosis;
CTNND1	6	cytoplasm; cytosol; protein binding; nucleus; Wnt receptor signaling pathway; plasma membrane;
PAK1	6	cytoplasm; Golgi apparatus; cytosol; protein binding; plasma membrane; apoptotic process;
PARK2	6	cytoplasm; mitochondrion; Golgi apparatus; cytosol; protein binding; nucleus;
PRKCB	6	cytoplasm; cytosol; protein binding; nucleus; plasma membrane; apoptotic process;
TJP1	6	cytoplasm; cytosol; protein binding; nucleus; plasma membrane; apoptotic process;
CYP2E1	5	oxidation-reduction process; mitochondrion; steroid metabolic process; oxidoreductase activity; enzyme binding;
TXN	5	oxidation-reduction process; mitochondrion; cytosol; protein binding; enzyme binding;
HEY2	5	protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; nucleus;
ID2	5	protein dimerization activity; cytoplasm; cytosol; protein binding; nucleus;
POU2F3	5	protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; nucleus;
FADD	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of apoptotic process; cytosol; protein binding; apoptotic process;
IRF7	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; cytosol; protein binding; nucleus;
KDM1A	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; oxidoreductase activity; enzyme binding;
PIK3R1	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of apoptotic process; cytosol; protein binding; plasma membrane;
RELA	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; cytosol; protein binding; nucleus;
UBB	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; protein binding; plasma membrane; apoptotic process;
UBC	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; protein binding; plasma membrane; apoptotic process;
UBE3A	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; cytosol; protein binding; nucleus;
YAP1	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; cytosol; protein binding; nucleus;
BCLAF1	5	positive regulation of apoptotic process; cytoplasm; protein binding; nucleus; induction of apoptosis;
RAD9A	5	positive regulation of apoptotic process; cytoplasm; protein binding; nucleus; enzyme binding;
CCND1	5	negative regulation of Wnt receptor signaling pathway; cytosol; protein binding; nucleus; enzyme binding;
DACT1	5	negative regulation of Wnt receptor signaling pathway; cytoplasm; protein binding; nucleus; Wnt receptor signaling pathway;
GRB10	5	negative regulation of Wnt receptor signaling pathway; cytoplasm; cytosol; protein binding; plasma membrane;
DAB2	5	cellular response to transforming growth factor beta stimulus; protein binding; nucleus; Wnt receptor signaling pathway; apoptotic process;
ADRB1	5	cytoplasm; protein binding; nucleus; plasma membrane; apoptotic process;
AIP	5	cytoplasm; cytosol; protein binding; nucleus; plasma membrane;
ARRB2	5	cytoplasm; cytosol; protein binding; nucleus; plasma membrane;
BAIAP2	5	cytoplasm; cytosol; protein binding; nucleus; plasma membrane;
CBL	5	cytoplasm; cytosol; protein binding; nucleus; plasma membrane;
CEP57	5	cytoplasm; Golgi apparatus; cytosol; protein binding; nucleus;
CHD1L	5	cytoplasm; nucleotide binding; protein binding; nucleus; plasma membrane;
CLASP2	5	cytoplasm; Golgi apparatus; cytosol; protein binding; plasma membrane;
COG3	5	cytoplasm; Golgi apparatus; protein binding; nucleus; plasma membrane;
DCPS	5	cytoplasm; mitochondrion; cytosol; protein binding; nucleus;
EGLN3	5	cytoplasm; cytosol; protein binding; nucleus; apoptotic process;
GOLPH3	5	cytoplasm; mitochondrion; cytosol; protein binding; plasma membrane;
GSTP1	5	cytoplasm; mitochondrion; cytosol; protein binding; nucleus;
GZMB	5	cytoplasm; cytosol; protein binding; nucleus; apoptotic process;
IGF2BP3	5	cytoplasm; cytosol; nucleotide binding; protein binding; nucleus;
INPPL1	5	cytoplasm; Golgi apparatus; cytosol; protein binding; plasma membrane;
KARS	5	cytoplasm; mitochondrion; cytosol; nucleus; plasma membrane;
MALT1	5	cytoplasm; cytosol; protein binding; nucleus; plasma membrane;
PDCD4	5	cytoplasm; cytosol; protein binding; nucleus; apoptotic process;
PLCE1	5	cytoplasm; cytosol; protein binding; enzyme binding; plasma membrane;
PRKG1	5	cytoplasm; Golgi apparatus; cytosol; protein binding; plasma membrane;
PSMC3	5	cytoplasm; cytosol; protein binding; nucleus; apoptotic process;
RPS3	5	cytoplasm; cytosol; protein binding; nucleus; induction of apoptosis;
SART1	5	cytoplasm; Golgi apparatus; cytosol; protein binding; nucleus;
SMNDC1	5	cytoplasm; protein binding; nucleus; apoptotic process; induction of apoptosis;
STXBP3	5	cytoplasm; cytosol; protein binding; nucleus; plasma membrane;
SYTL2	5	cytoplasm; Golgi apparatus; protein binding; nucleus; plasma membrane;
TH	5	cytoplasm; mitochondrion; cytosol; protein binding; nucleus;
WWP1	5	cytoplasm; cytosol; protein binding; nucleus; plasma membrane;
YES1	5	cytoplasm; Golgi apparatus; cytosol; enzyme binding; plasma membrane;
RIPK3	5	mitochondrion; cytosol; protein binding; plasma membrane; induction of apoptosis;
MAPT	5	cytosol; protein binding; enzyme binding; plasma membrane; apoptotic process;
PHLDA1	5	protein binding; nucleus; plasma membrane; apoptotic process; induction of apoptosis;

Genes shared at least 2 KEGG pathways with WWOX (count: 0)

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Region: chr16:78133551..79246564 View in gBrowse