ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NEK6
Symbol Alias	SID6-1512
Approved Name	NIMA (never in mitosis gene a)-related kinase 6
Name Alias	putative serine-threonine protein kinase
Location	9q33.3-q34.11
Position	chr9:127019885-127115586, +
External Links	HGNC: 7749 Entrez Gene: 10783 Ensembl: ENSG00000119408 UCSC: uc004boh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:2000772	regulation of cellular senescence	Biological Process		1
GO:0046777	protein autophosphorylation	Biological Process		23
GO:0051225	spindle assembly	Biological Process		4
GO:0006468	protein phosphorylation	Biological Process	IDA[12840024]	53
GO:0005874	microtubule	Cellular Component		52
GO:0005815	microtubule organizing center	Cellular Component		19
GO:0005737	cytoplasm	Cellular Component	IDA[12054534]	690
GO:0007165	signal transduction	Biological Process	IMP[12761501]	171
GO:0007067	mitosis	Biological Process		39
GO:0007059	chromosome segregation	Biological Process	IDA[14563848]	14
GO:0006915	apoptotic process	Biological Process		111
GO:0019894	kinesin binding	Molecular Function	IPI[19001501]	4
GO:0018105	peptidyl-serine phosphorylation	Biological Process	IDA[19001501]	12
GO:0016607	nuclear speck	Cellular Component		34
GO:0007346	regulation of mitotic cell cycle	Biological Process	TAS[16280549]	6
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IMP[12761501]	27
GO:0031572	G2/M transition DNA damage checkpoint	Biological Process	IMP[18728393]	7
GO:0030071	regulation of mitotic metaphase/anaphase transition	Biological Process	IDA[14563848]	1
GO:0019901	protein kinase binding	Molecular Function	IPI[19001501]	51
GO:0000287	magnesium ion binding	Molecular Function	IDA[14563848]	28
GO:0000910	cytokinesis	Biological Process		15
GO:0000922	spindle pole	Cellular Component		22
GO:0004674	protein serine/threonine kinase activity	Molecular Function		61
GO:0004871	signal transducer activity	Molecular Function	IMP[12761501]	49
GO:0005515	protein binding	Molecular Function	IPI[16476580]	910
GO:0005524	ATP binding	Molecular Function	IDA[14563848]	228
GO:0005634	nucleus	Cellular Component	IDA[12054534]	770

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NEK6 (count: 73)

Gene Symbol	Pathway Count	Pathway List
PLK1	12	protein phosphorylation; mitosis; peptidyl-serine phosphorylation; regulation of mitotic cell cycle; G2/M transition DNA damage checkpoint; protein kinase binding; cytokinesis; spindle pole; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
PRKD1	10	protein autophosphorylation; cytoplasm; signal transduction; apoptotic process; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
LATS1	9	protein phosphorylation; microtubule organizing center; mitosis; protein kinase binding; magnesium ion binding; spindle pole; protein serine/threonine kinase activity; protein binding; ATP binding;
PRKCB	9	protein phosphorylation; cytoplasm; signal transduction; apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
MAPK1	9	microtubule organizing center; cytoplasm; signal transduction; apoptotic process; peptidyl-serine phosphorylation; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
PAK1	8	protein autophosphorylation; protein phosphorylation; cytoplasm; apoptotic process; protein kinase binding; protein serine/threonine kinase activity; protein binding; ATP binding;
SIK2	8	protein autophosphorylation; protein phosphorylation; cytoplasm; magnesium ion binding; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
GSK3B	8	protein phosphorylation; cytoplasm; peptidyl-serine phosphorylation; protein kinase binding; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
ILK	8	protein phosphorylation; cytoplasm; peptidyl-serine phosphorylation; protein kinase binding; protein serine/threonine kinase activity; signal transducer activity; protein binding; ATP binding;
LATS2	8	protein phosphorylation; microtubule organizing center; mitosis; spindle pole; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
ATM	7	protein autophosphorylation; signal transduction; peptidyl-serine phosphorylation; G2/M transition DNA damage checkpoint; protein serine/threonine kinase activity; protein binding; ATP binding;
MAP3K11	7	protein autophosphorylation; protein phosphorylation; microtubule; cytoplasm; protein serine/threonine kinase activity; protein binding; ATP binding;
MARK2	7	protein autophosphorylation; protein phosphorylation; magnesium ion binding; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
SMG1	7	protein autophosphorylation; cytoplasm; peptidyl-serine phosphorylation; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
TSSK2	7	protein autophosphorylation; protein phosphorylation; cytoplasm; magnesium ion binding; protein serine/threonine kinase activity; protein binding; ATP binding;
RPS6KA4	7	protein phosphorylation; cytoplasm; magnesium ion binding; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
STK36	7	protein phosphorylation; cytoplasm; magnesium ion binding; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
TGFBR1	7	protein phosphorylation; signal transduction; apoptotic process; peptidyl-serine phosphorylation; protein serine/threonine kinase activity; protein binding; ATP binding;
SMC3	7	cytoplasm; signal transduction; mitosis; spindle pole; protein binding; ATP binding; nucleus;
ERBB2	6	protein autophosphorylation; protein phosphorylation; signal transduction; protein binding; ATP binding; nucleus;
RCC1	6	spindle assembly; cytoplasm; mitosis; chromosome segregation; protein binding; nucleus;
AURKC	6	protein phosphorylation; cytoplasm; cytokinesis; protein serine/threonine kinase activity; ATP binding; nucleus;
BIRC6	6	protein phosphorylation; microtubule organizing center; mitosis; apoptotic process; spindle pole; protein binding;
CDC42BPG	6	protein phosphorylation; cytoplasm; magnesium ion binding; protein serine/threonine kinase activity; protein binding; ATP binding;
CSNK1E	6	protein phosphorylation; signal transduction; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
ROCK2	6	protein phosphorylation; cytokinesis; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;
SIK3	6	protein phosphorylation; cytoplasm; magnesium ion binding; protein serine/threonine kinase activity; protein binding; ATP binding;
CDK5RAP2	6	microtubule; cytoplasm; chromosome segregation; protein kinase binding; spindle pole; protein binding;
KIF11	6	microtubule; cytoplasm; mitosis; protein kinase binding; spindle pole; ATP binding;
APBB1	6	cytoplasm; signal transduction; apoptotic process; nuclear speck; protein binding; nucleus;
PRC1	6	cytoplasm; protein kinase binding; cytokinesis; spindle pole; protein binding; nucleus;
TAOK2	6	cytoplasm; apoptotic process; G2/M transition DNA damage checkpoint; protein serine/threonine kinase activity; ATP binding; nucleus;
MAPK7	6	signal transduction; apoptotic process; peptidyl-serine phosphorylation; protein binding; ATP binding; nucleus;
AATK	5	protein autophosphorylation; apoptotic process; protein serine/threonine kinase activity; protein binding; ATP binding;
CDK12	5	protein autophosphorylation; nuclear speck; protein binding; ATP binding; nucleus;
FLT4	5	protein autophosphorylation; cytoplasm; protein binding; ATP binding; nucleus;
SYK	5	protein autophosphorylation; protein phosphorylation; protein kinase binding; protein binding; ATP binding;
ULK2	5	protein autophosphorylation; signal transduction; protein serine/threonine kinase activity; protein binding; ATP binding;
WNK2	5	protein autophosphorylation; protein phosphorylation; cytoplasm; protein serine/threonine kinase activity; ATP binding;
CFL1	5	protein phosphorylation; cytoplasm; cytokinesis; protein binding; nucleus;
ERN2	5	protein phosphorylation; apoptotic process; magnesium ion binding; protein serine/threonine kinase activity; ATP binding;
FRK	5	protein phosphorylation; cytoplasm; protein binding; ATP binding; nucleus;
IKBKAP	5	protein phosphorylation; cytoplasm; signal transduction; signal transducer activity; protein binding;
MAML1	5	protein phosphorylation; nuclear speck; protein kinase binding; protein binding; nucleus;
MAPK3	5	protein phosphorylation; apoptotic process; protein binding; ATP binding; nucleus;
MARK4	5	protein phosphorylation; microtubule organizing center; protein serine/threonine kinase activity; protein binding; ATP binding;
PRKAA1	5	protein phosphorylation; signal transduction; protein binding; ATP binding; nucleus;
PRKG1	5	protein phosphorylation; cytoplasm; signal transduction; protein binding; ATP binding;
SGK1	5	protein phosphorylation; apoptotic process; protein serine/threonine kinase activity; ATP binding; nucleus;
TSSK4	5	protein phosphorylation; magnesium ion binding; protein serine/threonine kinase activity; protein binding; ATP binding;
KIF22	5	microtubule; cytoplasm; mitosis; ATP binding; nucleus;
KIF23	5	microtubule; cytokinesis; protein binding; ATP binding; nucleus;
AATF	5	cytoplasm; apoptotic process; regulation of mitotic cell cycle; protein binding; nucleus;
ADRBK1	5	cytoplasm; signal transduction; peptidyl-serine phosphorylation; protein binding; ATP binding;
AIP	5	cytoplasm; signal transduction; signal transducer activity; protein binding; nucleus;
APC	5	cytoplasm; apoptotic process; protein kinase binding; protein binding; nucleus;
BIRC3	5	cytoplasm; apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein binding; nucleus;
MALT1	5	cytoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; protein binding; nucleus;
PARK2	5	cytoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein kinase binding; protein binding; nucleus;
PSMC3	5	cytoplasm; apoptotic process; protein binding; ATP binding; nucleus;
PTTG1	5	cytoplasm; mitosis; chromosome segregation; protein binding; nucleus;
RELA	5	cytoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein kinase binding; protein binding; nucleus;
SMNDC1	5	cytoplasm; apoptotic process; nuclear speck; protein binding; nucleus;
SNCA	5	cytoplasm; kinesin binding; magnesium ion binding; protein binding; nucleus;
TRAF1	5	cytoplasm; signal transduction; apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein binding;
TRIM13	5	cytoplasm; signal transduction; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; protein binding;
EEF1D	5	signal transduction; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; protein binding; nucleus;
GJA1	5	signal transduction; apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; protein binding;
MAP2K3	5	signal transduction; protein kinase binding; protein serine/threonine kinase activity; protein binding; ATP binding;
MAVS	5	signal transduction; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein kinase binding; signal transducer activity; protein binding;
PAK7	5	signal transduction; apoptotic process; protein serine/threonine kinase activity; ATP binding; nucleus;
KIF2C	5	mitosis; chromosome segregation; protein binding; ATP binding; nucleus;
CHEK1	5	G2/M transition DNA damage checkpoint; protein serine/threonine kinase activity; protein binding; ATP binding; nucleus;

Genes shared at least 2 KEGG pathways with NEK6 (count: 0)

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Region: chr9:127019885..127115586 View in gBrowse