ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FBXO4
Symbol Alias	FBX4
Approved Name	F-box protein 4
Previous Name	F-box only protein 4
Location	5p12
Position	chr5:41925356-41941845, +
External Links	HGNC: 13583 Entrez Gene: 26272 Ensembl: ENSG00000151876 UCSC: uc003jmq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function	IPI[16275645]	910
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA[10531035]	52
GO:0000723	telomere maintenance	Biological Process	IMP[16275645]	10
GO:0000209	protein polyubiquitination	Biological Process		23
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA[10531035]	15
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process		2
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IDA[16275645]	8
GO:0016567	protein ubiquitination	Biological Process	IDA[10531035]	41
GO:0019005	SCF ubiquitin ligase complex	Cellular Component		4
GO:0005737	cytoplasm	Cellular Component		690
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA[16275645]	25

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

Genes shared at least 5 GO terms with FBXO4 (count: 12)

Gene Symbol	Pathway Count	Pathway List
RCHY1	7	protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex; protein homodimerization activity; positive regulation of protein ubiquitination; protein ubiquitination; cytoplasm;
BARD1	6	protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex; protein homodimerization activity; protein ubiquitination; cytoplasm;
RNF40	6	protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex; protein homodimerization activity; cytoplasm; ubiquitin-dependent protein catabolic process;
FBXO25	5	protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex; protein ubiquitination; SCF ubiquitin ligase complex;
FBXO7	5	protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex; cytoplasm; ubiquitin-dependent protein catabolic process;
MALT1	5	protein binding; ubiquitin-protein ligase activity; positive regulation of protein ubiquitination; protein ubiquitination; cytoplasm;
PARK2	5	protein binding; ubiquitin-protein ligase activity; protein polyubiquitination; cytoplasm; ubiquitin-dependent protein catabolic process;
PRPF19	5	protein binding; ubiquitin-protein ligase activity; protein polyubiquitination; ubiquitin ligase complex; cytoplasm;
RNF20	5	protein binding; ubiquitin-protein ligase activity; protein polyubiquitination; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process;
TRIM32	5	protein binding; ubiquitin-protein ligase activity; protein polyubiquitination; protein ubiquitination; cytoplasm;
UBE4A	5	protein binding; protein polyubiquitination; ubiquitin ligase complex; cytoplasm; ubiquitin-dependent protein catabolic process;
WWP1	5	protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex; protein ubiquitination; cytoplasm;

Genes shared at least 2 KEGG pathways with FBXO4 (count: 0)

View in gBrowse

Region: chr5:41925356..41941845 View in gBrowse