ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RNF40
Symbol Alias	KIAA0661, RBP95, BRE1B, STARING
Approved Name	ring finger protein 40
Name Alias	BRE1 E3 ubiquitin ligase homolog B (S. cerevisiae)
Location	16p11.2-p11.1
Position	chr16:30773599-30787628, +
External Links	HGNC: 16867 Entrez Gene: 9810 Ensembl: ENSG00000103549 UCSC: uc002dzq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0033523	histone H2B ubiquitination	Biological Process	IDA[16307923]	2
GO:0033503	HULC complex	Cellular Component	IDA[19410543]	2
GO:0043005	neuron projection	Cellular Component		35
GO:0042803	protein homodimerization activity	Molecular Function	IPI[10944455]	113
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI[16307923]	23
GO:0032403	protein complex binding	Molecular Function		27
GO:0010390	histone monoubiquitination	Biological Process	IDA[16307923]	2
GO:0017075	syntaxin-1 binding	Molecular Function		8
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process		25
GO:0008270	zinc ion binding	Molecular Function		323
GO:0005737	cytoplasm	Cellular Component		690
GO:0005886	plasma membrane	Cellular Component		772
GO:0005634	nucleus	Cellular Component		770
GO:0005730	nucleolus	Cellular Component		243
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA[16307923]	52
GO:0005515	protein binding	Molecular Function	IPI[19410543]	910
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA[16307923]	15

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with RNF40 (count: 61)

Gene Symbol	Pathway Count	Pathway List
RNF20	11	histone H2B ubiquitination; HULC complex; ubiquitin protein ligase binding; histone monoubiquitination; ubiquitin-dependent protein catabolic process; zinc ion binding; nucleus; nucleolus; ubiquitin-protein ligase activity; protein binding; ubiquitin ligase complex;
RCHY1	8	protein homodimerization activity; zinc ion binding; cytoplasm; nucleus; nucleolus; ubiquitin-protein ligase activity; protein binding; ubiquitin ligase complex;
BARD1	7	protein homodimerization activity; zinc ion binding; cytoplasm; nucleus; ubiquitin-protein ligase activity; protein binding; ubiquitin ligase complex;
TRIM5	7	protein homodimerization activity; zinc ion binding; cytoplasm; nucleus; nucleolus; ubiquitin-protein ligase activity; protein binding;
PARK2	7	ubiquitin protein ligase binding; ubiquitin-dependent protein catabolic process; zinc ion binding; cytoplasm; nucleus; ubiquitin-protein ligase activity; protein binding;
BAIAP2	6	neuron projection; cytoplasm; plasma membrane; nucleus; nucleolus; protein binding;
DAXX	6	protein homodimerization activity; ubiquitin protein ligase binding; cytoplasm; nucleus; nucleolus; protein binding;
FBXO4	6	protein homodimerization activity; ubiquitin-dependent protein catabolic process; cytoplasm; ubiquitin-protein ligase activity; protein binding; ubiquitin ligase complex;
PAFAH1B1	6	protein homodimerization activity; protein complex binding; cytoplasm; nucleus; nucleolus; protein binding;
ARRB2	6	ubiquitin protein ligase binding; protein complex binding; cytoplasm; plasma membrane; nucleus; protein binding;
GSK3B	6	ubiquitin protein ligase binding; cytoplasm; plasma membrane; nucleus; nucleolus; protein binding;
HERC2	6	ubiquitin protein ligase binding; zinc ion binding; cytoplasm; nucleus; ubiquitin-protein ligase activity; protein binding;
STXBP3	6	syntaxin-1 binding; cytoplasm; plasma membrane; nucleus; nucleolus; protein binding;
FBXO7	6	ubiquitin-dependent protein catabolic process; cytoplasm; nucleus; ubiquitin-protein ligase activity; protein binding; ubiquitin ligase complex;
CBL	6	zinc ion binding; cytoplasm; plasma membrane; nucleus; ubiquitin-protein ligase activity; protein binding;
RNF2	6	zinc ion binding; nucleus; nucleolus; ubiquitin-protein ligase activity; protein binding; ubiquitin ligase complex;
MALT1	6	cytoplasm; plasma membrane; nucleus; nucleolus; ubiquitin-protein ligase activity; protein binding;
WWP1	6	cytoplasm; plasma membrane; nucleus; ubiquitin-protein ligase activity; protein binding; ubiquitin ligase complex;
SLC6A4	5	neuron projection; protein homodimerization activity; syntaxin-1 binding; plasma membrane; protein binding;
SNAP23	5	neuron projection; plasma membrane; nucleus; nucleolus; protein binding;
SNAP29	5	neuron projection; cytoplasm; plasma membrane; nucleus; nucleolus;
CEP57	5	protein homodimerization activity; cytoplasm; nucleus; nucleolus; protein binding;
CORO1A	5	protein homodimerization activity; cytoplasm; plasma membrane; nucleus; protein binding;
CRYAB	5	protein homodimerization activity; cytoplasm; plasma membrane; nucleus; protein binding;
CRYM	5	protein homodimerization activity; cytoplasm; plasma membrane; nucleus; nucleolus;
FOXP1	5	protein homodimerization activity; zinc ion binding; cytoplasm; nucleus; nucleolus;
FZD4	5	protein homodimerization activity; ubiquitin protein ligase binding; cytoplasm; plasma membrane; protein binding;
KLHL7	5	protein homodimerization activity; cytoplasm; plasma membrane; nucleus; nucleolus;
PDE2A	5	protein homodimerization activity; cytoplasm; plasma membrane; nucleus; protein binding;
TFAP2A	5	protein homodimerization activity; cytoplasm; nucleus; nucleolus; protein binding;
ARRB1	5	ubiquitin protein ligase binding; cytoplasm; plasma membrane; nucleus; protein binding;
CUL5	5	ubiquitin protein ligase binding; ubiquitin-dependent protein catabolic process; plasma membrane; nucleus; protein binding;
RELA	5	ubiquitin protein ligase binding; protein complex binding; cytoplasm; nucleus; protein binding;
XRCC5	5	ubiquitin protein ligase binding; cytoplasm; nucleus; nucleolus; protein binding;
FLCN	5	protein complex binding; cytoplasm; plasma membrane; nucleus; protein binding;
STRN3	5	protein complex binding; cytoplasm; plasma membrane; nucleus; protein binding;
UBE3A	5	ubiquitin-dependent protein catabolic process; cytoplasm; nucleus; ubiquitin-protein ligase activity; protein binding;
BIRC3	5	zinc ion binding; cytoplasm; nucleus; ubiquitin-protein ligase activity; protein binding;
BRAP	5	zinc ion binding; cytoplasm; ubiquitin-protein ligase activity; protein binding; ubiquitin ligase complex;
DPP3	5	zinc ion binding; cytoplasm; plasma membrane; nucleus; nucleolus;
FUS	5	zinc ion binding; cytoplasm; nucleus; nucleolus; protein binding;
LPXN	5	zinc ion binding; cytoplasm; plasma membrane; nucleus; protein binding;
PGR	5	zinc ion binding; cytoplasm; nucleus; nucleolus; protein binding;
PRKCB	5	zinc ion binding; cytoplasm; plasma membrane; nucleus; protein binding;
RBM4	5	zinc ion binding; cytoplasm; nucleus; nucleolus; protein binding;
RFWD2	5	zinc ion binding; cytoplasm; nucleus; nucleolus; protein binding;
RNF144B	5	zinc ion binding; cytoplasm; ubiquitin-protein ligase activity; protein binding; ubiquitin ligase complex;
SNCA	5	zinc ion binding; cytoplasm; plasma membrane; nucleus; protein binding;
TNFAIP3	5	zinc ion binding; cytoplasm; nucleus; ubiquitin-protein ligase activity; protein binding;
TRIM32	5	zinc ion binding; cytoplasm; nucleus; ubiquitin-protein ligase activity; protein binding;
ZFR	5	zinc ion binding; cytoplasm; nucleus; nucleolus; protein binding;
AIP	5	cytoplasm; plasma membrane; nucleus; nucleolus; protein binding;
CDCA5	5	cytoplasm; plasma membrane; nucleus; nucleolus; protein binding;
CHD1L	5	cytoplasm; plasma membrane; nucleus; nucleolus; protein binding;
COG3	5	cytoplasm; plasma membrane; nucleus; nucleolus; protein binding;
KLHL20	5	cytoplasm; nucleus; nucleolus; ubiquitin-protein ligase activity; protein binding;
NF2	5	cytoplasm; plasma membrane; nucleus; nucleolus; protein binding;
PRC1	5	cytoplasm; plasma membrane; nucleus; nucleolus; protein binding;
PRPF19	5	cytoplasm; nucleus; ubiquitin-protein ligase activity; protein binding; ubiquitin ligase complex;
RRP8	5	cytoplasm; plasma membrane; nucleus; nucleolus; protein binding;
SAP18	5	cytoplasm; plasma membrane; nucleus; nucleolus; protein binding;

Genes shared at least 2 KEGG pathways with RNF40 (count: 0)

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Region: chr16:30773599..30787628 View in gBrowse