ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RCHY1
Previous Symbol	ZNF363
Symbol Alias	CHIMP, DKFZp586C1620, PRO1996, RNF199, ARNIP
Approved Name	ring finger and CHY zinc finger domain containing 1
Previous Name	zinc finger protein 363
Name Alias	androgen-receptor N-terminal-interacting protein
Location	4q21.1-q21.3
Position	chr4:76404247-76439974, -
External Links	HGNC: 17479 Entrez Gene: 25898 Ensembl: ENSG00000163743 UCSC: uc003hik.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_43	chr4:75931128-77058132 (NCBI Build 36.1 (hg18))	1076977	4q13.3-4q21.1	Gain	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA[19043414]	15
GO:0002039	p53 binding	Molecular Function	IPI[19043414]	11
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component		770
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA[19483087]	52
GO:0005102	receptor binding	Molecular Function		61
GO:0008270	zinc ion binding	Molecular Function	IDA[19043414]	323
GO:0016567	protein ubiquitination	Biological Process	IDA[19043414]	41
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component		690
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IDA[19483087]	5
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Biological Process	IDA[19483087]	16
GO:0016607	nuclear speck	Cellular Component		34
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IDA[19483087]	8
GO:0051865	protein autoubiquitination	Biological Process	IDA[19483087]	6
GO:0042803	protein homodimerization activity	Molecular Function	IPI[19483087]	113

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04115	p53 signaling pathway	14	p53 activation is induced by a number of stress signals, inc...... p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways. More...
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...
hsa05162	Measles	20	Measles virus (MV) is highly contagious virus that leads inf...... Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation. More...

Genes shared at least 5 GO terms with RCHY1 (count: 51)

Gene Symbol	Pathway Count	Pathway List
BARD1	8	ubiquitin ligase complex; protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; protein ubiquitination; cytoplasm; protein homodimerization activity;
RNF40	8	ubiquitin ligase complex; protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; nucleolus; cytoplasm; protein homodimerization activity;
FBXO4	7	ubiquitin ligase complex; protein binding; ubiquitin-protein ligase activity; protein ubiquitination; cytoplasm; positive regulation of protein ubiquitination; protein homodimerization activity;
RNF20	7	ubiquitin ligase complex; p53 binding; protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; nucleolus;
WWP1	7	ubiquitin ligase complex; protein binding; nucleus; ubiquitin-protein ligase activity; protein ubiquitination; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
HERC2	7	protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; protein ubiquitination; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
MALT1	7	protein binding; nucleus; ubiquitin-protein ligase activity; protein ubiquitination; nucleolus; cytoplasm; positive regulation of protein ubiquitination;
PARK2	7	protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein autoubiquitination;
RFWD2	7	protein binding; nucleus; zinc ion binding; protein ubiquitination; nucleolus; cytoplasm; nuclear speck;
TRIM32	7	protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; protein ubiquitination; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
TRIM5	7	protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; nucleolus; cytoplasm; protein homodimerization activity;
PRPF19	6	ubiquitin ligase complex; protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; nuclear speck;
RNF144B	6	ubiquitin ligase complex; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
RNF2	6	ubiquitin ligase complex; protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; nucleolus;
DAXX	6	p53 binding; protein binding; nucleus; nucleolus; cytoplasm; protein homodimerization activity;
RFWD3	6	p53 binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; protein ubiquitination; cytoplasm;
ARRB2	6	protein binding; nucleus; receptor binding; protein ubiquitination; cytoplasm; positive regulation of protein ubiquitination;
CBL	6	protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; protein ubiquitination; cytoplasm;
KLHL20	6	protein binding; nucleus; ubiquitin-protein ligase activity; protein ubiquitination; nucleolus; cytoplasm;
NEDD4L	6	protein binding; nucleus; ubiquitin-protein ligase activity; protein ubiquitination; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
PGR	6	protein binding; nucleus; receptor binding; zinc ion binding; nucleolus; cytoplasm;
RBM4	6	protein binding; nucleus; zinc ion binding; nucleolus; cytoplasm; nuclear speck;
RNF146	6	protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein autoubiquitination;
TRIP12	6	protein binding; nucleus; ubiquitin-protein ligase activity; protein ubiquitination; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
ZBTB16	6	protein binding; nucleus; zinc ion binding; protein ubiquitination; nuclear speck; protein homodimerization activity;
BRAP	5	ubiquitin ligase complex; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm;
FBXO25	5	ubiquitin ligase complex; protein binding; nucleus; ubiquitin-protein ligase activity; protein ubiquitination;
FBXO7	5	ubiquitin ligase complex; protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm;
GSK3B	5	p53 binding; protein binding; nucleus; nucleolus; cytoplasm;
BIRC3	5	protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm;
CEP57	5	protein binding; nucleus; nucleolus; cytoplasm; protein homodimerization activity;
CRBN	5	protein binding; nucleus; protein ubiquitination; nucleolus; cytoplasm;
EFTUD2	5	protein binding; nucleus; nucleolus; cytoplasm; nuclear speck;
FUS	5	protein binding; nucleus; zinc ion binding; nucleolus; cytoplasm;
HECTD1	5	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
HERC5	5	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
LRSAM1	5	protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm; protein autoubiquitination;
PAFAH1B1	5	protein binding; nucleus; nucleolus; cytoplasm; protein homodimerization activity;
PSPC1	5	protein binding; nucleus; nucleolus; cytoplasm; nuclear speck;
SF3A3	5	protein binding; nucleus; zinc ion binding; nucleolus; nuclear speck;
SYVN1	5	protein binding; nucleus; zinc ion binding; protein ubiquitination; nucleolus;
TFAP2A	5	protein binding; nucleus; nucleolus; cytoplasm; protein homodimerization activity;
TNFAIP3	5	protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm;
TRIM13	5	protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm; protein autoubiquitination;
U2AF1	5	protein binding; nucleus; zinc ion binding; nucleolus; nuclear speck;
UBE3A	5	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
ZFR	5	protein binding; nucleus; zinc ion binding; nucleolus; cytoplasm;
FOXP1	5	nucleus; zinc ion binding; nucleolus; cytoplasm; protein homodimerization activity;
KLHL7	5	nucleus; protein ubiquitination; nucleolus; cytoplasm; protein homodimerization activity;
SLU7	5	nucleus; zinc ion binding; nucleolus; cytoplasm; nuclear speck;
TRIM22	5	nucleus; zinc ion binding; protein ubiquitination; cytoplasm; nuclear speck;

Genes shared at least 2 KEGG pathways with RCHY1 (count: 2)

Gene Symbol	Pathway Count	Pathway List
CCND1	2	p53 signaling pathway; Measles;
RFWD2	2	p53 signaling pathway; Ubiquitin mediated proteolysis;

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Region: chr4:76404247..76439974 View in gBrowse