ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GABRG3
Approved Name	gamma-aminobutyric acid (GABA) A receptor, gamma 3
Location	15q11-q13
Position	chr15:27216429-27778373, +
External Links	HGNC: 4088 Entrez Gene: 2567 Ensembl: ENSG00000182256 UCSC: uc001zbg.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_46	chr15:21016722-25902239 (NCBI Build 36.1 (hg18))	4933636	15q11.2-15q13.1	Gain

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
15q11.2-13.3	chr15:20700000-33600000	1 (1/0/0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	No. of Genes in ADHDgene
GO:0045211	postsynaptic membrane	Cellular Component	41
GO:0042493	response to drug	Biological Process	68
GO:0034707	chloride channel complex	Cellular Component	7
GO:0034220	ion transmembrane transport	Biological Process	11
GO:0030054	cell junction	Cellular Component	77
GO:0016021	integral to membrane	Cellular Component	845
GO:0007268	synaptic transmission	Biological Process	96
GO:0007214	gamma-aminobutyric acid signaling pathway	Biological Process	5
GO:0055085	transmembrane transport	Biological Process	82
GO:0004890	GABA-A receptor activity	Molecular Function	4
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	7
GO:0005254	chloride channel activity	Molecular Function	6
GO:0005886	plasma membrane	Cellular Component	772

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with GABRG3 (count: 13)

Gene Symbol	Pathway Count	Pathway List
GABRA5	11	postsynaptic membrane; chloride channel complex; ion transmembrane transport; cell junction; synaptic transmission; gamma-aminobutyric acid signaling pathway; transmembrane transport; GABA-A receptor activity; extracellular ligand-gated ion channel activity; chloride channel activity; plasma membrane;
GABRB3	10	postsynaptic membrane; chloride channel complex; ion transmembrane transport; cell junction; synaptic transmission; transmembrane transport; GABA-A receptor activity; extracellular ligand-gated ion channel activity; chloride channel activity; plasma membrane;
GABRG1	9	postsynaptic membrane; chloride channel complex; cell junction; synaptic transmission; gamma-aminobutyric acid signaling pathway; GABA-A receptor activity; extracellular ligand-gated ion channel activity; chloride channel activity; plasma membrane;
HTR3A	8	postsynaptic membrane; ion transmembrane transport; cell junction; integral to membrane; synaptic transmission; transmembrane transport; extracellular ligand-gated ion channel activity; plasma membrane;
CHRNA3	5	postsynaptic membrane; cell junction; integral to membrane; synaptic transmission; plasma membrane;
CHRNA4	5	postsynaptic membrane; cell junction; integral to membrane; synaptic transmission; plasma membrane;
CHRNA7	5	postsynaptic membrane; cell junction; integral to membrane; synaptic transmission; plasma membrane;
CHRNB4	5	postsynaptic membrane; cell junction; integral to membrane; synaptic transmission; plasma membrane;
GABBR2	5	postsynaptic membrane; cell junction; synaptic transmission; gamma-aminobutyric acid signaling pathway; plasma membrane;
GRIN2A	5	postsynaptic membrane; response to drug; cell junction; synaptic transmission; plasma membrane;
HTR3B	5	postsynaptic membrane; ion transmembrane transport; synaptic transmission; transmembrane transport; plasma membrane;
SLC1A3	5	response to drug; integral to membrane; synaptic transmission; transmembrane transport; plasma membrane;
SLC6A3	5	response to drug; integral to membrane; synaptic transmission; transmembrane transport; plasma membrane;

Genes shared at least 2 KEGG pathways with GABRG3 (count: 0)

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Region: chr15:27216429..27778373 View in gBrowse