ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CHRNB4
Approved Name	cholinergic receptor, nicotinic, beta 4
Previous Name	cholinergic receptor, nicotinic, beta polypeptide 4
Location	15q24
Position	chr15:78916461-78933587, -
External Links	HGNC: 1964 Entrez Gene: 1143 Ensembl: ENSG00000117971 UCSC: uc002bed.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 12)

Literature-origin SNPs (count: 0)

LD-proxies (count: 12)

rs_ID	Location	Functional Annotation
rs1021071	Chr15:78968179(Fwd)	intron_variant; nc_transcript_variant
rs11072785	Chr15:78968229(Fwd)	intron_variant; nc_transcript_variant
rs11639372	Chr15:78966655(Fwd)	intron_variant; nc_transcript_variant
rs12902602	Chr15:78967401(Fwd)	intron_variant; nc_transcript_variant
rs12899135	Chr15:78954379(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs1996371	Chr15:78956806(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs11634351	Chr15:78944718(Fwd)	NMD_transcript_variant; intron_variant
rs11638830	Chr15:78948319(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs17487223	Chr15:78923987(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant
rs922692	Chr15:78984214(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs4887077	Chr15:78978364(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs11638372	Chr15:78983559(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0060084	synaptic transmission involved in micturition	Biological Process	IMP[11450844]	2
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0046928	regulation of neurotransmitter secretion	Biological Process	NAS[11742001]	5
GO:0001508	regulation of action potential	Biological Process		2
GO:0005892	acetylcholine-gated channel complex	Cellular Component	IDA[8906617]; TAS[11742001]	5
GO:0005887	integral to plasma membrane	Cellular Component	IC[11742001]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0004889	acetylcholine-activated cation-selective channel activity	Molecular Function	TAS[11742001]	5
GO:0007165	signal transduction	Biological Process	IDA[8906617]	171
GO:0006940	regulation of smooth muscle contraction	Biological Process		5
GO:0006939	smooth muscle contraction	Biological Process		10
GO:0006811	ion transport	Biological Process	TAS[8906617]	25
GO:0015276	ligand-gated ion channel activity	Molecular Function		4
GO:0007626	locomotory behavior	Biological Process		24
GO:0007271	synaptic transmission, cholinergic	Biological Process	TAS[1330682]	8
GO:0007268	synaptic transmission	Biological Process		96
GO:0035095	behavioral response to nicotine	Biological Process		4
GO:0030054	cell junction	Cellular Component		77
GO:0016021	integral to membrane	Cellular Component	NAS[8906617]	845
GO:0015464	acetylcholine receptor activity	Molecular Function	IDA[8906617]	5

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with CHRNB4 (count: 20)

Gene Symbol	Pathway Count	Pathway List
CHRNA3	16	synaptic transmission involved in micturition; postsynaptic membrane; acetylcholine-gated channel complex; plasma membrane; acetylcholine-activated cation-selective channel activity; signal transduction; regulation of smooth muscle contraction; ion transport; ligand-gated ion channel activity; locomotory behavior; synaptic transmission, cholinergic; synaptic transmission; behavioral response to nicotine; cell junction; integral to membrane; acetylcholine receptor activity;
CHRNA4	15	postsynaptic membrane; regulation of action potential; acetylcholine-gated channel complex; plasma membrane; acetylcholine-activated cation-selective channel activity; signal transduction; ion transport; ligand-gated ion channel activity; locomotory behavior; synaptic transmission, cholinergic; synaptic transmission; behavioral response to nicotine; cell junction; integral to membrane; acetylcholine receptor activity;
CHRNA5	10	postsynaptic membrane; acetylcholine-gated channel complex; plasma membrane; acetylcholine-activated cation-selective channel activity; signal transduction; ligand-gated ion channel activity; synaptic transmission; behavioral response to nicotine; cell junction; acetylcholine receptor activity;
CHRNA7	10	postsynaptic membrane; acetylcholine-gated channel complex; plasma membrane; acetylcholine-activated cation-selective channel activity; signal transduction; ion transport; synaptic transmission; cell junction; integral to membrane; acetylcholine receptor activity;
CHRM3	6	postsynaptic membrane; integral to plasma membrane; plasma membrane; signal transduction; smooth muscle contraction; cell junction;
GABRA5	6	postsynaptic membrane; integral to plasma membrane; plasma membrane; signal transduction; synaptic transmission; cell junction;
GABRB3	6	postsynaptic membrane; integral to plasma membrane; plasma membrane; signal transduction; synaptic transmission; cell junction;
HTR3A	6	postsynaptic membrane; integral to plasma membrane; plasma membrane; synaptic transmission; cell junction; integral to membrane;
ACHE	5	postsynaptic membrane; plasma membrane; synaptic transmission, cholinergic; synaptic transmission; cell junction;
ADORA2A	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; locomotory behavior; synaptic transmission, cholinergic;
CHRM1	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; signal transduction; cell junction;
GABBR2	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; synaptic transmission; cell junction;
GABRG3	5	postsynaptic membrane; plasma membrane; synaptic transmission; cell junction; integral to membrane;
GRIK1	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; synaptic transmission; cell junction;
GRIK4	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; synaptic transmission; cell junction;
GRIN2A	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; synaptic transmission; cell junction;
GRIN2B	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; synaptic transmission; cell junction;
GRM7	5	postsynaptic membrane; integral to plasma membrane; plasma membrane; synaptic transmission; integral to membrane;
RAPSN	5	postsynaptic membrane; plasma membrane; synaptic transmission, cholinergic; synaptic transmission; cell junction;
SLC6A3	5	integral to plasma membrane; plasma membrane; locomotory behavior; synaptic transmission; integral to membrane;

Genes shared at least 2 KEGG pathways with CHRNB4 (count: 0)

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Region: chr15:78916461..78933587 View in gBrowse