ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SERPINC1
Previous Symbol	AT3
Symbol Alias	ATIII, MGC22579
Approved Name	serpin peptidase inhibitor, clade C (antithrombin), member 1
Previous Name	serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
Name Alias	antithrombin III, "signal peptide antithrombin part 1", "coding sequence signal peptide antithrombin part 1", "antithrombin (aa 375-432)"
Location	1q23-q25.1
Position	chr1:173872939-173886516, -
External Links	HGNC: 775 Entrez Gene: 462 Ensembl: ENSG00000117601 UCSC: uc001gjt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.1	chr1:172900000-176000000	1 (1/0/0)

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function	IPI[12878203]	910
GO:0004867	serine-type endopeptidase inhibitor activity	Molecular Function	NAS[12878203]	10
GO:0005615	extracellular space	Cellular Component	IDA[1695900]	126
GO:0005576	extracellular region	Cellular Component	NAS[14718574]	240
GO:0007584	response to nutrient	Biological Process		15
GO:0005886	plasma membrane	Cellular Component		772
GO:0008201	heparin binding	Molecular Function		26
GO:0007596	blood coagulation	Biological Process		83
GO:0030162	regulation of proteolysis	Biological Process		6
GO:0010951	negative regulation of endopeptidase activity	Biological Process		7
GO:0050728	negative regulation of inflammatory response	Biological Process		11
GO:0002020	protease binding	Molecular Function	IPI[15853774]	13

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04610	Complement and coagulation cascades	12	The complement system is a proteolytic cascade in blood plas...... The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. More...

Genes shared at least 5 GO terms with SERPINC1 (count: 7)

Gene Symbol	Pathway Count	Pathway List
APOA1	7	protein binding; extracellular space; extracellular region; response to nutrient; plasma membrane; blood coagulation; negative regulation of inflammatory response;
SERPING1	6	protein binding; serine-type endopeptidase inhibitor activity; extracellular space; extracellular region; blood coagulation; negative regulation of endopeptidase activity;
SERPIND1	6	serine-type endopeptidase inhibitor activity; extracellular region; heparin binding; blood coagulation; regulation of proteolysis; negative regulation of endopeptidase activity;
FN1	5	protein binding; extracellular space; extracellular region; heparin binding; blood coagulation;
LPL	5	protein binding; extracellular space; extracellular region; plasma membrane; heparin binding;
VEGFA	5	protein binding; extracellular space; extracellular region; heparin binding; blood coagulation;
VEGFB	5	protein binding; extracellular space; extracellular region; heparin binding; blood coagulation;

Genes shared at least 2 KEGG pathways with SERPINC1 (count: 0)

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Region: chr1:173872939..173886516 View in gBrowse