ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	VEGFA
Previous Symbol	VEGF
Symbol Alias	VEGF-A, VPF
Approved Name	vascular endothelial growth factor A
Previous Name	vascular endothelial growth factor
Location	6p12
Position	chr6:43737921-43754224, +
External Links	HGNC: 12680 Entrez Gene: 7422 Ensembl: ENSG00000112715 UCSC: uc003owh.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6458351	Chr6:43791080(Fwd)		1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 113)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 113)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001541	ovarian follicle development	Biological Process		4
GO:0001569	patterning of blood vessels	Biological Process		7
GO:0001570	vasculogenesis	Biological Process	TAS[15015550]	10
GO:0001666	response to hypoxia	Biological Process	IDA[16490744]	34
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[18093989]	78
GO:0001525	angiogenesis	Biological Process	IDA[11427521]	35
GO:0001968	fibronectin binding	Molecular Function	IDA[14570917]	3
GO:0002042	cell migration involved in sprouting angiogenesis	Biological Process		2
GO:0002052	positive regulation of neuroblast proliferation	Biological Process		4
GO:0002053	positive regulation of mesenchymal cell proliferation	Biological Process		9
GO:0001701	in utero embryonic development	Biological Process		32
GO:0001822	kidney development	Biological Process		16
GO:0001934	positive regulation of protein phosphorylation	Biological Process	IDA[18386220]	22
GO:0001938	positive regulation of endothelial cell proliferation	Biological Process	IDA[10022831]	8
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA[7929439]	69
GO:0008360	regulation of cell shape	Biological Process	IDA[10527820]	20
GO:0008083	growth factor activity	Molecular Function		25
GO:0008201	heparin binding	Molecular Function	IDA[15001987]; IMP[14570917]	26
GO:0007595	lactation	Biological Process		7
GO:0007596	blood coagulation	Biological Process		83
GO:0007399	nervous system development	Biological Process	TAS[15351965]	54
GO:0007498	mesoderm development	Biological Process		9
GO:0030168	platelet activation	Biological Process		38
GO:0030224	monocyte differentiation	Biological Process		3
GO:0016020	membrane	Cellular Component		139
GO:0030141	secretory granule	Cellular Component	IDA[17082651]	17
GO:0010628	positive regulation of gene expression	Biological Process	IDA[18386220]	28
GO:0010740	positive regulation of intracellular protein kinase cascade	Biological Process		2
GO:0009986	cell surface	Cellular Component	IDA[17470632]	70
GO:0010595	positive regulation of endothelial cell migration	Biological Process		7
GO:0005125	cytokine activity	Molecular Function	IDA[18440775]	19
GO:0003169	coronary vein morphogenesis	Biological Process		1
GO:0003151	outflow tract morphogenesis	Biological Process		12
GO:0003007	heart morphogenesis	Biological Process		5
GO:0002687	positive regulation of leukocyte migration	Biological Process	TAS[1312256]	1
GO:0002576	platelet degranulation	Biological Process		12
GO:0002575	basophil chemotaxis	Biological Process	IDA[17082651]	1
GO:0002092	positive regulation of receptor internalization	Biological Process		7
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	IMP[18093989]	42
GO:0005737	cytoplasm	Cellular Component	IDA[17082651]	690
GO:0005615	extracellular space	Cellular Component	IDA[9202027]	126
GO:0005578	proteinaceous extracellular matrix	Cellular Component	NAS[14570917]	47
GO:0005576	extracellular region	Cellular Component		240
GO:0005515	protein binding	Molecular Function		910
GO:0005172	vascular endothelial growth factor receptor binding	Molecular Function	IPI[10471394]	1
GO:0005161	platelet-derived growth factor receptor binding	Molecular Function	IPI[17470632]	2
GO:0032793	positive regulation of CREB transcription factor activity	Biological Process		6
GO:0033138	positive regulation of peptidyl-serine phosphorylation	Biological Process		10
GO:0031954	positive regulation of protein autophosphorylation	Biological Process		4
GO:0032147	activation of protein kinase activity	Biological Process	IDA[18059339]	5
GO:0035924	cellular response to vascular endothelial growth factor stimulus	Biological Process	IDA[18440775]	3
GO:0036303	lymph vessel morphogenesis	Biological Process		1
GO:0033554	cellular response to stress	Biological Process		12
GO:0035767	endothelial cell chemotaxis	Biological Process	IDA[18440775]	1
GO:0030335	positive regulation of cell migration	Biological Process	IDA[7929439]	29
GO:0030855	epithelial cell differentiation	Biological Process		7
GO:0030225	macrophage differentiation	Biological Process		2
GO:0030324	lung development	Biological Process		12
GO:0031093	platelet alpha granule lumen	Cellular Component		5
GO:0031334	positive regulation of protein complex assembly	Biological Process	IDA[16489009]	4
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	Biological Process	IDA[7929439]	6
GO:0031077	post-embryonic camera-type eye development	Biological Process		2
GO:0043183	vascular endothelial growth factor receptor 1 binding	Molecular Function	IPI[1312256]	2
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Biological Process	IDA[18386220]	9
GO:0043129	surfactant homeostasis	Biological Process		3
GO:0043117	positive regulation of vascular permeability	Biological Process	IDA[16109918]	4
GO:0043536	positive regulation of blood vessel endothelial cell migration	Biological Process		3
GO:0043498	cell surface binding	Molecular Function	IDA[17470632]	3
GO:0043406	positive regulation of MAP kinase activity	Biological Process	IDA[18440775]	10
GO:0043184	vascular endothelial growth factor receptor 2 binding	Molecular Function		2
GO:0042056	chemoattractant activity	Molecular Function		5
GO:0040007	growth	Biological Process		4
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	Biological Process	IDA[17470632]	1
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	Biological Process		2
GO:0043066	negative regulation of apoptotic process	Biological Process	IMP[10066377]	77
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0042802	identical protein binding	Molecular Function		70
GO:0042462	eye photoreceptor cell development	Biological Process		3
GO:0048739	cardiac muscle fiber development	Biological Process		3
GO:0048754	branching morphogenesis of a tube	Biological Process		6
GO:0048844	artery morphogenesis	Biological Process		9
GO:0050679	positive regulation of epithelial cell proliferation	Biological Process		9
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Biological Process	IDA[10022831]	14
GO:0050840	extracellular matrix binding	Molecular Function	IC[14570917]	3
GO:0050918	positive chemotaxis	Biological Process	IDA[19275959]	7
GO:0050927	positive regulation of positive chemotaxis	Biological Process	IDA[12744932]	3
GO:0045766	positive regulation of angiogenesis	Biological Process	IMP[18275976]	12
GO:0045785	positive regulation of cell adhesion	Biological Process	IDA[19674970]	7
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[18093989]; IMP[18093989]	131
GO:0046982	protein heterodimerization activity	Molecular Function	IDA[8702615]	68
GO:0048010	vascular endothelial growth factor receptor signaling pathway	Biological Process		6
GO:0048018	receptor agonist activity	Molecular Function		2
GO:0048469	cell maturation	Biological Process		6
GO:0048593	camera-type eye morphogenesis	Biological Process		2
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	Biological Process		5
GO:0060982	coronary artery morphogenesis	Biological Process		2
GO:0071456	cellular response to hypoxia	Biological Process	IDA[10575000]	12
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	Biological Process	IMP[19652095]	1
GO:0090037	positive regulation of protein kinase C signaling cascade	Biological Process	IDA[18059339]	6
GO:0071542	dopaminergic neuron differentiation	Biological Process		3
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Biological Process		5
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	Biological Process		2
GO:0051272	positive regulation of cellular component movement	Biological Process	IDA[10527820]	5
GO:0050930	induction of positive chemotaxis	Biological Process	IDA[19275959]; NAS[12744932]	6
GO:0051894	positive regulation of focal adhesion assembly	Biological Process	IDA[16489009]	4
GO:0051781	positive regulation of cell division	Biological Process		11
GO:0060749	mammary gland alveolus development	Biological Process		5
GO:0060319	primitive erythrocyte differentiation	Biological Process		2
GO:0060948	cardiac vascular smooth muscle cell development	Biological Process		2
GO:0060754	positive regulation of mast cell chemotaxis	Biological Process	IDA[19275959]	2
GO:1901727	positive regulation of histone deacetylase activity	Biological Process		2
GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	Biological Process		2
GO:1900745	positive regulation of p38MAPK cascade	Biological Process	IDA[18386220]	1

Gene related KEGG pathways (count: 9)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05219	Bladder cancer	7	The urothelium covers the luminal surface of almost the enti...... The urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carcinoma are bladder carcinomas, and urothelial carcinomas of the renal pelvis and ureter account for only approximately 7% of the total. Urothelial tumours arise and evolve through divergent phenotypic pathways. Some tumours progress from urothelial hyperplasia to low-grade non-invasive superficial papillary tumours. More aggressive variants arise either from flat, high-grade carcinoma in situ (CIS) and progress to invasive tumours, or they arise de novo as invasive tumours. Low-grade papillary tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. In contrast, CIS and invasive tumors frequently show alterations in the TP53 and RB genes and pathways. Invasion and metastases are promoted by several factors that alter the tumour microenvironment, including the aberrant expression of E-cadherins (E-cad), matrix metalloproteinases (MMPs), angiogenic factors such as vascular endothelial growth factor (VEGF). More...
hsa05211	Renal cell carcinoma	13	Renal cell cancer (RCC) accounts for ~3% of human malignanci...... Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal cancer accounts for 1-4% of cases. RCC is not a single disease, it has several morphological subtypes. Conventional RCC (clear cell RCC) accounts for ~80% of cases, followed by papillary RCC (10-15%), chromophobe RCC (5%), and collecting duct RCC (<1%). Genes potentially involved in sporadic neoplasms of each particular type are VHL, MET, BHD, and FH respectively. In the absence of VHL, hypoxia-inducible factor alpha (HIF-alpha) accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. Activated MET mediates a number of biological effects including motility, invasion of extracellular matrix, cellular transformation, prevention of apoptosis and metastasis formation. Loss of functional FH leads to accumulation of fumarate in the cell, triggering inhibition of HPH and preventing targeted pVHL-mediated degradation of HIF-alpha. BHD mutations cause the Birt-Hogg-Dube syndrome and its associated chromophobe, hybrid oncocytic, and conventional (clear cell) RCC. More...
hsa05323	Rheumatoid arthritis	17	Rheumatoid arthritis (RA) is a chronic autoimmune joint dise...... Rheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune system elevates pro-inflammatory cytokines and chemokines levels, which can promote synovial angiogenesis and leukocyte infiltration. The synovium forms a hyperplastic pannus with infiltrated macrophage-like and fibroblast-like synoviocytes and invades joints by secreting proteinases and inducing osteoclast differentiation. More...
hsa05212	Pancreatic cancer	13	Infiltrating ductal adenocarcinoma is the most common malign...... Infiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA). Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors (PanINs). The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, inactivation of the p16 gene at an intermediate stage, and the inactivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple effector pathways. Although EGF receptors are conventionally regarded as upstream activators of RAS proteins, they can also act as RAS signal transducers via RAS-induced autocrine activation of the EGFR family ligands. Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes. Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signalling pathway. More...
hsa04510	Focal adhesion	40	Cell-matrix adhesions play essential roles in important biol...... Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04370	VEGF signaling pathway	19	There is now much evidence that VEGFR-2 is the major mediato...... There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling. More...
hsa04150	mTOR signaling pathway	13
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with VEGFA (count: 123)

Gene Symbol	Pathway Count	Pathway List
VEGFB	25	angiogenesis; positive regulation of endothelial cell proliferation; growth factor activity; heparin binding; blood coagulation; platelet activation; membrane; platelet degranulation; extracellular space; extracellular region; protein binding; platelet alpha granule lumen; positive regulation of vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor receptor 1 binding; positive regulation of vascular permeability; chemoattractant activity; negative regulation of apoptotic process; protein homodimerization activity; positive regulation of peptidyl-tyrosine phosphorylation; positive chemotaxis; protein heterodimerization activity; vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis; positive regulation of cell division; positive regulation of mast cell chemotaxis;
FGF10	15	angiogenesis; growth factor activity; heparin binding; cell surface; extracellular space; extracellular region; positive regulation of vascular endothelial growth factor receptor signaling pathway; chemoattractant activity; negative regulation of apoptotic process; branching morphogenesis of a tube; positive regulation of epithelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive chemotaxis; positive regulation of transcription from RNA polymerase II promoter; induction of positive chemotaxis;
PRKD1	15	angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of endothelial cell migration; cytoplasm; protein binding; positive regulation of CREB transcription factor activity; positive regulation of peptidyl-serine phosphorylation; cellular response to vascular endothelial growth factor stimulus; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; identical protein binding; positive regulation of angiogenesis; positive regulation of transcription from RNA polymerase II promoter; vascular endothelial growth factor receptor signaling pathway; positive regulation of histone deacetylase activity;
TBX1	14	angiogenesis; positive regulation of mesenchymal cell proliferation; positive regulation of protein phosphorylation; positive regulation of cell proliferation; mesoderm development; outflow tract morphogenesis; heart morphogenesis; regulation of transcription from RNA polymerase II promoter; epithelial cell differentiation; protein homodimerization activity; artery morphogenesis; positive regulation of epithelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; coronary artery morphogenesis;
GREM1	13	cell migration involved in sprouting angiogenesis; positive regulation of cell proliferation; cell surface; cytokine activity; positive regulation of receptor internalization; extracellular space; protein binding; vascular endothelial growth factor receptor 2 binding; positive regulation of angiogenesis; positive regulation of transcription from RNA polymerase II promoter; receptor agonist activity; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of peptidyl-tyrosine autophosphorylation;
IL6	13	positive regulation of cell proliferation; regulation of cell shape; growth factor activity; platelet activation; cytokine activity; extracellular space; extracellular region; positive regulation of peptidyl-serine phosphorylation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; positive regulation of epithelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter;
MIF	13	cell surface; cytokine activity; cytoplasm; extracellular space; extracellular region; protein binding; positive regulation of peptidyl-serine phosphorylation; cell surface binding; positive regulation of MAP kinase activity; chemoattractant activity; negative regulation of apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive chemotaxis;
FGF9	12	angiogenesis; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; growth factor activity; heparin binding; positive regulation of gene expression; cytoplasm; extracellular space; extracellular region; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of epithelial cell proliferation; positive regulation of cell division;
NTF3	12	positive regulation of cell proliferation; growth factor activity; nervous system development; positive regulation of receptor internalization; extracellular region; positive regulation of peptidyl-serine phosphorylation; positive regulation of cell migration; chemoattractant activity; positive regulation of peptidyl-tyrosine phosphorylation; positive chemotaxis; positive regulation of transcription from RNA polymerase II promoter; induction of positive chemotaxis;
HES1	11	negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; nervous system development; outflow tract morphogenesis; cytoplasm; protein binding; lung development; protein homodimerization activity; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; cell maturation;
CTGF	11	angiogenesis; fibronectin binding; positive regulation of protein phosphorylation; positive regulation of cell proliferation; growth factor activity; heparin binding; positive regulation of gene expression; extracellular space; proteinaceous extracellular matrix; extracellular region; lung development;
FN1	11	angiogenesis; regulation of cell shape; heparin binding; blood coagulation; platelet activation; platelet degranulation; extracellular space; proteinaceous extracellular matrix; extracellular region; protein binding; platelet alpha granule lumen;
FLT4	11	positive regulation of protein phosphorylation; positive regulation of endothelial cell proliferation; positive regulation of cell proliferation; positive regulation of endothelial cell migration; cytoplasm; extracellular region; protein binding; cellular response to vascular endothelial growth factor stimulus; negative regulation of apoptotic process; vascular endothelial growth factor receptor signaling pathway; positive regulation of protein kinase C signaling cascade;
FOXC2	10	patterning of blood vessels; vasculogenesis; negative regulation of transcription from RNA polymerase II promoter; mesoderm development; positive regulation of endothelial cell migration; negative regulation of apoptotic process; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; vascular endothelial growth factor receptor signaling pathway; positive regulation of cell migration involved in sprouting angiogenesis;
TFAP2A	10	negative regulation of transcription from RNA polymerase II promoter; kidney development; positive regulation of gene expression; outflow tract morphogenesis; cytoplasm; protein binding; positive regulation of cell migration; negative regulation of apoptotic process; protein homodimerization activity; positive regulation of transcription from RNA polymerase II promoter;
ADRA2A	10	positive regulation of cell proliferation; blood coagulation; platelet activation; cytoplasm; protein binding; activation of protein kinase activity; positive regulation of cell migration; positive regulation of MAP kinase activity; protein homodimerization activity; protein heterodimerization activity;
IL12B	10	growth factor activity; membrane; cytokine activity; cytoplasm; extracellular space; protein binding; protein homodimerization activity; identical protein binding; positive regulation of cell adhesion; protein heterodimerization activity;
INS	9	positive regulation of cell proliferation; secretory granule; extracellular space; extracellular region; protein binding; positive regulation of protein autophosphorylation; positive regulation of cell migration; negative regulation of apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation;
WNT11	9	positive regulation of gene expression; outflow tract morphogenesis; cytoplasm; extracellular space; proteinaceous extracellular matrix; positive regulation of cell migration; negative regulation of apoptotic process; artery morphogenesis; positive regulation of protein kinase C signaling cascade;
PTPRJ	8	vasculogenesis; blood coagulation; cell surface; protein binding; platelet-derived growth factor receptor binding; positive chemotaxis; positive regulation of cell adhesion; positive regulation of focal adhesion assembly;
ADAM17	8	response to hypoxia; positive regulation of protein phosphorylation; positive regulation of cell proliferation; cell surface; cytoplasm; protein binding; positive regulation of cell migration; positive regulation of cellular component movement;
BNIP3	8	response to hypoxia; cytoplasm; protein binding; negative regulation of apoptotic process; protein homodimerization activity; identical protein binding; protein heterodimerization activity; cellular response to hypoxia;
IL18	8	response to hypoxia; angiogenesis; positive regulation of gene expression; cytokine activity; extracellular space; extracellular region; lung development; positive regulation of vascular permeability;
FLCN	8	negative regulation of transcription from RNA polymerase II promoter; in utero embryonic development; positive regulation of protein phosphorylation; positive regulation of gene expression; cytoplasm; protein binding; positive regulation of cell adhesion; positive regulation of transcription from RNA polymerase II promoter;
GATA6	8	negative regulation of transcription from RNA polymerase II promoter; in utero embryonic development; blood coagulation; protein binding; negative regulation of apoptotic process; positive regulation of angiogenesis; positive regulation of transcription from RNA polymerase II promoter; cellular response to hypoxia;
HNF1B	8	negative regulation of transcription from RNA polymerase II promoter; kidney development; protein binding; negative regulation of apoptotic process; protein homodimerization activity; branching morphogenesis of a tube; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity;
MED1	8	negative regulation of transcription from RNA polymerase II promoter; angiogenesis; lactation; monocyte differentiation; positive regulation of gene expression; protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
SEMA4D	8	negative regulation of transcription from RNA polymerase II promoter; positive regulation of protein phosphorylation; regulation of cell shape; extracellular space; protein binding; positive regulation of cell migration; negative regulation of apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation;
PIK3CG	8	angiogenesis; blood coagulation; platelet activation; membrane; cytoplasm; protein binding; positive regulation of MAP kinase activity; negative regulation of apoptotic process;
TGFBR1	8	angiogenesis; in utero embryonic development; kidney development; positive regulation of cell proliferation; protein binding; negative regulation of apoptotic process; artery morphogenesis; positive regulation of cellular component movement;
ERBB2	8	positive regulation of protein phosphorylation; nervous system development; protein binding; positive regulation of MAP kinase activity; identical protein binding; positive regulation of epithelial cell proliferation; positive regulation of cell adhesion; protein heterodimerization activity;
FGF4	8	positive regulation of protein phosphorylation; positive regulation of cell proliferation; growth factor activity; heparin binding; extracellular region; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell division;
IGF2	8	positive regulation of protein phosphorylation; positive regulation of cell proliferation; growth factor activity; extracellular space; extracellular region; protein binding; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell division;
APOA1	8	blood coagulation; platelet activation; secretory granule; platelet degranulation; extracellular space; extracellular region; protein binding; identical protein binding;
INHA	7	ovarian follicle development; growth factor activity; nervous system development; cytokine activity; extracellular region; protein binding; protein heterodimerization activity;
EDNRA	7	patterning of blood vessels; response to hypoxia; in utero embryonic development; positive regulation of protein phosphorylation; positive regulation of cell proliferation; membrane; negative regulation of apoptotic process;
IHH	7	patterning of blood vessels; positive regulation of mesenchymal cell proliferation; in utero embryonic development; extracellular space; extracellular region; positive regulation of transcription from RNA polymerase II promoter; cell maturation;
FOXF1	7	vasculogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mesenchymal cell proliferation; in utero embryonic development; positive regulation of cell migration; lung development; positive regulation of transcription from RNA polymerase II promoter;
HEY2	7	vasculogenesis; negative regulation of transcription from RNA polymerase II promoter; outflow tract morphogenesis; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; cardiac vascular smooth muscle cell development;
CRYAB	7	response to hypoxia; cell surface; cytoplasm; protein binding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; protein homodimerization activity;
ETS1	7	response to hypoxia; positive regulation of cell proliferation; protein binding; positive regulation of cell migration; positive regulation of angiogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cellular component movement;
NR4A2	7	response to hypoxia; cytoplasm; protein binding; cellular response to stress; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; dopaminergic neuron differentiation;
PAK1	7	response to hypoxia; cytoplasm; protein binding; positive regulation of peptidyl-serine phosphorylation; cellular response to stress; identical protein binding; branching morphogenesis of a tube;
KDM1A	7	negative regulation of transcription from RNA polymerase II promoter; in utero embryonic development; blood coagulation; regulation of transcription from RNA polymerase II promoter; protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
PDE2A	7	negative regulation of transcription from RNA polymerase II promoter; blood coagulation; monocyte differentiation; cytoplasm; protein binding; positive regulation of vascular permeability; protein homodimerization activity;
EREG	7	angiogenesis; positive regulation of cell proliferation; growth factor activity; extracellular space; extracellular region; protein binding; positive regulation of cell division;
FOXP1	7	positive regulation of mesenchymal cell proliferation; in utero embryonic development; cytoplasm; lung development; protein homodimerization activity; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity;
APC	7	kidney development; cytoplasm; protein binding; positive regulation of cell migration; negative regulation of apoptotic process; positive regulation of cell adhesion; positive regulation of cell division;
CLCF1	7	positive regulation of cell proliferation; growth factor activity; cytokine activity; extracellular region; protein binding; negative regulation of apoptotic process; protein heterodimerization activity;
ALDOA	7	regulation of cell shape; blood coagulation; platelet activation; platelet degranulation; extracellular region; platelet alpha granule lumen; identical protein binding;
GDNF	7	growth factor activity; nervous system development; extracellular region; negative regulation of apoptotic process; protein homodimerization activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of branching involved in ureteric bud morphogenesis;
BCAR1	7	blood coagulation; platelet activation; positive regulation of endothelial cell migration; cytoplasm; protein binding; positive regulation of cell migration; vascular endothelial growth factor receptor signaling pathway;
PRKCB	7	blood coagulation; platelet activation; regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of angiogenesis;
SERPING1	7	blood coagulation; platelet activation; platelet degranulation; extracellular space; extracellular region; protein binding; platelet alpha granule lumen;
ACHE	7	nervous system development; membrane; cell surface; extracellular space; extracellular region; protein binding; protein homodimerization activity;
SNCA	7	cytoplasm; extracellular region; protein binding; positive regulation of peptidyl-serine phosphorylation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; identical protein binding;
CXCL12	6	patterning of blood vessels; growth factor activity; extracellular space; extracellular region; negative regulation of apoptotic process; induction of positive chemotaxis;
FZD4	6	vasculogenesis; cell surface; cytoplasm; protein binding; protein homodimerization activity; protein heterodimerization activity;
YAP1	6	vasculogenesis; positive regulation of cell proliferation; cytoplasm; protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
DRD2	6	response to hypoxia; positive regulation of neuroblast proliferation; positive regulation of receptor internalization; protein binding; activation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter;
EGLN3	6	response to hypoxia; cytoplasm; protein binding; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia;
PRKAA1	6	response to hypoxia; positive regulation of cell proliferation; positive regulation of gene expression; protein binding; negative regulation of apoptotic process; cellular response to hypoxia;
ID2	6	negative regulation of transcription from RNA polymerase II promoter; positive regulation of gene expression; cytoplasm; protein binding; cell maturation; mammary gland alveolus development;
ISL1	6	negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; outflow tract morphogenesis; cytoplasm; positive regulation of angiogenesis; positive regulation of transcription from RNA polymerase II promoter;
RBPJ	6	negative regulation of transcription from RNA polymerase II promoter; angiogenesis; outflow tract morphogenesis; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter;
UBB	6	negative regulation of transcription from RNA polymerase II promoter; protein binding; cellular response to stress; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia;
UBC	6	negative regulation of transcription from RNA polymerase II promoter; protein binding; cellular response to stress; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia;
ADAM8	6	angiogenesis; cell surface; cytoplasm; protein binding; positive regulation of cell adhesion; cellular response to hypoxia;
JAM3	6	angiogenesis; blood coagulation; extracellular space; protein binding; protein homodimerization activity; protein heterodimerization activity;
PDCD10	6	angiogenesis; positive regulation of cell proliferation; protein binding; positive regulation of MAP kinase activity; negative regulation of apoptotic process; protein homodimerization activity;
CDH13	6	positive regulation of endothelial cell proliferation; cytoplasm; extracellular space; positive regulation of cell migration; positive regulation of positive chemotaxis; positive regulation of transcription from RNA polymerase II promoter;
BTC	6	positive regulation of cell proliferation; growth factor activity; extracellular space; extracellular region; negative regulation of apoptotic process; positive regulation of cell division;
MAPK1	6	positive regulation of cell proliferation; blood coagulation; platelet activation; cytoplasm; protein binding; positive regulation of cell migration;
RELA	6	positive regulation of cell proliferation; cytoplasm; protein binding; negative regulation of apoptotic process; identical protein binding; positive regulation of transcription from RNA polymerase II promoter;
CORO1A	6	regulation of cell shape; cytoplasm; protein binding; positive regulation of cell migration; protein homodimerization activity; positive chemotaxis;
VIL1	6	regulation of cell shape; cytoplasm; protein binding; positive regulation of cell migration; protein homodimerization activity; identical protein binding;
ADRA2C	6	blood coagulation; platelet activation; cytoplasm; protein binding; protein homodimerization activity; protein heterodimerization activity;
ARRB1	6	blood coagulation; platelet activation; cytoplasm; protein binding; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter;
ARRB2	6	blood coagulation; platelet activation; positive regulation of receptor internalization; cytoplasm; protein binding; positive regulation of peptidyl-tyrosine phosphorylation;
CFL1	6	blood coagulation; platelet activation; platelet degranulation; cytoplasm; protein binding; negative regulation of apoptotic process;
F7	6	blood coagulation; extracellular space; extracellular region; positive regulation of cell migration; negative regulation of apoptotic process; positive regulation of positive chemotaxis;
HABP4	6	blood coagulation; platelet activation; platelet degranulation; cytoplasm; extracellular region; protein binding;
HSPA5	6	blood coagulation; platelet activation; cell surface; platelet degranulation; protein binding; negative regulation of apoptotic process;
PIK3R1	6	blood coagulation; platelet activation; protein binding; positive regulation of cell migration; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
WNT6	6	positive regulation of gene expression; cell surface; extracellular space; proteinaceous extracellular matrix; extracellular region; branching morphogenesis of a tube;
GHR	6	cell surface; extracellular space; extracellular region; protein binding; protein homodimerization activity; positive regulation of peptidyl-tyrosine phosphorylation;
GSK3B	6	cytoplasm; protein binding; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein complex assembly; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
TPD52L1	6	cytoplasm; protein binding; positive regulation of MAP kinase activity; protein homodimerization activity; identical protein binding; protein heterodimerization activity;
SEMA3E	5	patterning of blood vessels; regulation of cell shape; membrane; extracellular space; extracellular region;
NTRK2	5	vasculogenesis; positive regulation of cell proliferation; positive regulation of gene expression; cell surface; protein homodimerization activity;
BDNF	5	response to hypoxia; growth factor activity; nervous system development; cytoplasm; extracellular region;
TH	5	response to hypoxia; heart morphogenesis; cytoplasm; protein binding; eye photoreceptor cell development;
IKZF1	5	negative regulation of transcription from RNA polymerase II promoter; mesoderm development; cytoplasm; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity;
MEN1	5	negative regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell division;
MYB	5	negative regulation of transcription from RNA polymerase II promoter; in utero embryonic development; blood coagulation; protein binding; positive regulation of transcription from RNA polymerase II promoter;
SREBF1	5	negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; protein binding; lung development; positive regulation of transcription from RNA polymerase II promoter;
AAMP	5	angiogenesis; heparin binding; cell surface; positive regulation of endothelial cell migration; cytoplasm;
SYK	5	angiogenesis; blood coagulation; platelet activation; protein binding; positive regulation of peptidyl-tyrosine phosphorylation;
FOXP2	5	positive regulation of mesenchymal cell proliferation; cytoplasm; growth; protein homodimerization activity; protein heterodimerization activity;
DAB2	5	in utero embryonic development; positive regulation of protein phosphorylation; protein binding; positive regulation of cell migration; negative regulation of apoptotic process;
TSC1	5	kidney development; membrane; cytoplasm; protein binding; positive regulation of focal adhesion assembly;
CCND1	5	positive regulation of protein phosphorylation; lactation; membrane; protein binding; mammary gland alveolus development;
MAPK3	5	positive regulation of protein phosphorylation; blood coagulation; platelet activation; protein binding; positive regulation of transcription from RNA polymerase II promoter;
SQSTM1	5	positive regulation of protein phosphorylation; protein binding; protein homodimerization activity; identical protein binding; positive regulation of transcription from RNA polymerase II promoter;
CNTF	5	positive regulation of cell proliferation; growth factor activity; cytoplasm; extracellular space; growth;
CTF1	5	positive regulation of cell proliferation; nervous system development; cytokine activity; extracellular space; extracellular region;
FGF19	5	positive regulation of cell proliferation; growth factor activity; nervous system development; extracellular region; protein binding;
FGF3	5	positive regulation of cell proliferation; growth factor activity; extracellular region; protein binding; positive regulation of cell division;
ILK	5	positive regulation of cell proliferation; cytoplasm; protein binding; positive regulation of cell migration; positive regulation of MAP kinase activity;
CDC42EP2	5	regulation of cell shape; membrane; cytoplasm; protein binding; positive regulation of protein complex assembly;
NGF	5	growth factor activity; positive regulation of gene expression; extracellular space; extracellular region; positive regulation of protein autophosphorylation;
OGN	5	growth factor activity; extracellular space; proteinaceous extracellular matrix; extracellular region; protein binding;
CTSG	5	heparin binding; secretory granule; cell surface; extracellular space; extracellular region;
LPL	5	heparin binding; cell surface; extracellular space; extracellular region; protein binding;
SERPINC1	5	heparin binding; blood coagulation; extracellular space; extracellular region; protein binding;
PRLR	5	lactation; cell surface; extracellular region; negative regulation of apoptotic process; protein homodimerization activity;
ADORA2A	5	blood coagulation; membrane; protein binding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; protein heterodimerization activity;
STX4	5	blood coagulation; platelet activation; membrane; cell surface; protein binding;
ZFPM1	5	blood coagulation; outflow tract morphogenesis; cytoplasm; protein binding; primitive erythrocyte differentiation;
PLA2G1B	5	secretory granule; extracellular space; extracellular region; cell surface binding; positive regulation of transcription from RNA polymerase II promoter;
TCEB1	5	regulation of transcription from RNA polymerase II promoter; protein binding; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia;
BARD1	5	cytoplasm; protein binding; negative regulation of apoptotic process; protein homodimerization activity; protein heterodimerization activity;
TTR	5	cytoplasm; extracellular space; extracellular region; protein binding; protein heterodimerization activity;

Genes shared at least 2 KEGG pathways with VEGFA (count: 35)

Gene Symbol	Pathway Count	Pathway List
VEGFB	8	Bladder cancer; Renal cell carcinoma; Rheumatoid arthritis; Pancreatic cancer; Focal adhesion; Cytokine-cytokine receptor interaction; mTOR signaling pathway; Pathways in cancer;
MAPK1	7	Bladder cancer; Renal cell carcinoma; Pancreatic cancer; Focal adhesion; VEGF signaling pathway; mTOR signaling pathway; Pathways in cancer;
MAPK3	7	Bladder cancer; Renal cell carcinoma; Pancreatic cancer; Focal adhesion; VEGF signaling pathway; mTOR signaling pathway; Pathways in cancer;
PIK3CG	6	Renal cell carcinoma; Pancreatic cancer; Focal adhesion; VEGF signaling pathway; mTOR signaling pathway; Pathways in cancer;
PIK3R1	6	Renal cell carcinoma; Pancreatic cancer; Focal adhesion; VEGF signaling pathway; mTOR signaling pathway; Pathways in cancer;
CCND1	4	Bladder cancer; Pancreatic cancer; Focal adhesion; Pathways in cancer;
ERBB2	4	Bladder cancer; Pancreatic cancer; Focal adhesion; Pathways in cancer;
BAD	4	Pancreatic cancer; Focal adhesion; VEGF signaling pathway; Pathways in cancer;
MMP1	3	Bladder cancer; Rheumatoid arthritis; Pathways in cancer;
CRKL	3	Renal cell carcinoma; Focal adhesion; Pathways in cancer;
IL6	3	Rheumatoid arthritis; Cytokine-cytokine receptor interaction; Pathways in cancer;
MAPK9	3	Pancreatic cancer; Focal adhesion; Pathways in cancer;
TGFBR1	3	Pancreatic cancer; Cytokine-cytokine receptor interaction; Pathways in cancer;
PRKCB	3	Focal adhesion; VEGF signaling pathway; Pathways in cancer;
EGLN3	2	Renal cell carcinoma; Pathways in cancer;
ETS1	2	Renal cell carcinoma; Pathways in cancer;
PAK1	2	Renal cell carcinoma; Focal adhesion;
PAK7	2	Renal cell carcinoma; Focal adhesion;
TCEB1	2	Renal cell carcinoma; Pathways in cancer;
CXCL12	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;
IL18	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;
TNFRSF11A	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;
PLD1	2	Pancreatic cancer; Pathways in cancer;
RELA	2	Pancreatic cancer; Pathways in cancer;
BIRC2	2	Focal adhesion; Pathways in cancer;
BIRC3	2	Focal adhesion; Pathways in cancer;
FLT4	2	Focal adhesion; Cytokine-cytokine receptor interaction;
FN1	2	Focal adhesion; Pathways in cancer;
GSK3B	2	Focal adhesion; Pathways in cancer;
ITGA2	2	Focal adhesion; Pathways in cancer;
LAMA2	2	Focal adhesion; Pathways in cancer;
LAMA3	2	Focal adhesion; Pathways in cancer;
LAMC1	2	Focal adhesion; Pathways in cancer;
LAMC2	2	Focal adhesion; Pathways in cancer;
PLCG2	2	VEGF signaling pathway; Pathways in cancer;

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Region: chr6:43737921..43754224 View in gBrowse