ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	APOA1
Approved Name	apolipoprotein A-I
Location	11q23-q24
Position	chr11:116706467-116708666, -
External Links	HGNC: 600 Entrez Gene: 335 Ensembl: ENSG00000118137 UCSC: uc001ppv.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 77)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 77)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001540	beta-amyloid binding	Molecular Function	IDA[11297421]	6
GO:0002740	negative regulation of cytokine secretion involved in immune response	Biological Process	IDA[12458630]	1
GO:0002576	platelet degranulation	Biological Process		12
GO:0001935	endothelial cell proliferation	Biological Process		2
GO:0001932	regulation of protein phosphorylation	Biological Process		4
GO:0005548	phospholipid transporter activity	Molecular Function		2
GO:0005576	extracellular region	Cellular Component		240
GO:0005515	protein binding	Molecular Function	IPI[17786215]	910
GO:0005543	phospholipid binding	Molecular Function	IDA[12810715]	61
GO:0005788	endoplasmic reticulum lumen	Cellular Component		33
GO:0005886	plasma membrane	Cellular Component		772
GO:0005615	extracellular space	Cellular Component	IDA[19433579]	126
GO:0005634	nucleus	Cellular Component		770
GO:0006695	cholesterol biosynthetic process	Biological Process		7
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	IDA[16443932]	72
GO:0006629	lipid metabolic process	Biological Process		51
GO:0006656	phosphatidylcholine biosynthetic process	Biological Process	IDA[4335615]	6
GO:0008035	high-density lipoprotein particle binding	Molecular Function		2
GO:0008203	cholesterol metabolic process	Biological Process	IMP[15464323]	16
GO:0007584	response to nutrient	Biological Process		15
GO:0007596	blood coagulation	Biological Process		83
GO:0070328	triglyceride homeostasis	Biological Process		7
GO:0060761	negative regulation of response to cytokine stimulus	Biological Process		3
GO:0070653	high-density lipoprotein particle receptor binding	Molecular Function	IPI[10764676]	2
GO:0070508	cholesterol import	Biological Process	IMP[14718538]	2
GO:0060192	negative regulation of lipase activity	Biological Process		1
GO:0055102	lipase inhibitor activity	Molecular Function		3
GO:0060354	negative regulation of cell adhesion molecule production	Biological Process		1
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	Molecular Function	IDA[4335615]	2
GO:0051345	positive regulation of hydrolase activity	Biological Process	IDA[7638166]	1
GO:0051347	positive regulation of transferase activity	Biological Process		2
GO:0055085	transmembrane transport	Biological Process		82
GO:0055091	phospholipid homeostasis	Biological Process		3
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0050713	negative regulation of interleukin-1 beta secretion	Biological Process	IDA[12458630]	1
GO:0050728	negative regulation of inflammatory response	Biological Process		11
GO:0050821	protein stabilization	Biological Process	IDA[17655203]	10
GO:0043534	blood vessel endothelial cell migration	Biological Process		2
GO:0043627	response to estrogen stimulus	Biological Process		11
GO:0043691	reverse cholesterol transport	Biological Process	IMP[15464323]	7
GO:0044255	cellular lipid metabolic process	Biological Process		30
GO:0042158	lipoprotein biosynthetic process	Biological Process		1
GO:0042493	response to drug	Biological Process		68
GO:0042632	cholesterol homeostasis	Biological Process	IMP[15464323]	18
GO:0042802	identical protein binding	Molecular Function	IPI[8049247]	70
GO:0042157	lipoprotein metabolic process	Biological Process		11
GO:0034384	high-density lipoprotein particle clearance	Biological Process	IC[12651854]	3
GO:0034380	high-density lipoprotein particle assembly	Biological Process	IDA[190223]	2
GO:0034375	high-density lipoprotein particle remodeling	Biological Process	IC[4335615]	5
GO:0034366	spherical high-density lipoprotein particle	Cellular Component	IDA[16682745]	3
GO:0034364	high-density lipoprotein particle	Cellular Component		3
GO:0034361	very-low-density lipoprotein particle	Cellular Component	IDA[17154273]	6
GO:0034191	apolipoprotein A-I receptor binding	Molecular Function	IPI[16443932]	1
GO:0034190	apolipoprotein receptor binding	Molecular Function	IPI[11162594]	1
GO:0034115	negative regulation of heterotypic cell-cell adhesion	Biological Process		4
GO:0033700	phospholipid efflux	Biological Process	IDA[11162594]	5
GO:0033344	cholesterol efflux	Biological Process	IDA[15358760]	8
GO:0032489	regulation of Cdc42 protein signal transduction	Biological Process	IDA[16443932]	3
GO:0031410	cytoplasmic vesicle	Cellular Component	IDA[14703508]	20
GO:0031100	organ regeneration	Biological Process		11
GO:0030325	adrenal gland development	Biological Process		3
GO:0030300	regulation of intestinal cholesterol absorption	Biological Process		2
GO:0030301	cholesterol transport	Biological Process	IDA[10559507]	2
GO:0030141	secretory granule	Cellular Component		17
GO:0030168	platelet activation	Biological Process		38
GO:0019915	lipid storage	Biological Process		4
GO:0030139	endocytic vesicle	Cellular Component	IDA[14747463]	12
GO:0018206	peptidyl-methionine modification	Biological Process	IDA[12576517]	1
GO:0019899	enzyme binding	Molecular Function	IPI[1587806]	47
GO:0017127	cholesterol transporter activity	Molecular Function	IDA[9651324]; IMP[15464323]	5
GO:0018158	protein oxidation	Biological Process	IDA[12576517]	1
GO:0014012	peripheral nervous system axon regeneration	Biological Process		2
GO:0015485	cholesterol binding	Molecular Function	IDA[15464323]	10
GO:0010873	positive regulation of cholesterol esterification	Biological Process	IDA[4335615]	2
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	Biological Process	IDA[14967812]	2
GO:0008211	glucocorticoid metabolic process	Biological Process		1
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	Biological Process		2

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05143	African trypanosomiasis	8	Trypanosoma brucei, the parasite responsible for African try...... Trypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brain barrier and cause neurological damage by inducing cytokines like TNF alpha, IFN gamma, and IL1. These cytokines and other metabolites such as nitric oxide and somnogenic prostaglandin D2 disturb circadian rhythms in patients with African trypanosomiasis. More...
hsa04975	Fat digestion and absorption	19	Fat is an important energy source from food. More than 95% o...... Fat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, dietary TAG is hydrolyzed to fatty acids (FA) and monoacylglycerols (MAG) by pancreatic lipase. These products are then emulsified with the help of phospholipids (PL) and bile acids (BA) present in bile to form micelles. Free FAs and MAGs are taken up by the enterocyte where they are rapidly resynthesized in endoplasmic reticulum (ER) to form TAG. PLs from the diet as well as bile - mainly LPA - too are absorbed by the enterocyte and are acylated to form phosphatidic acid (PA), which is also converted into TAG. Absorbed cholesterol (CL) is acylated to cholesterol esters (CE). Within the ER, TAG joins CE and apolipoprotein B (ApoB) to form chylomicrons that enter circulation through the lymph. More...
hsa04977	Vitamin digestion and absorption	7	Vitamins are a diverse and chemically unrelated group of org...... Vitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactions. Because humans and other mammals cannot synthesize these compounds (except for some synthesis of niacin), they must obtain them from exogenous sources via intestinal absorption. Vitamins are classified based on their solubility in water or fat. Most of the water-soluble vitamins are transported across the small intestinal membrane by carrier-mediated mechanisms, but vitamin B12, cobalamin, is transported by a receptor-mediated mechanism. Intestinal absorption of fat-soluble vitamins requires all of the processes needed for fat absorption. After digestion, these vitamins and the products of pancreatic hydrolysis of triglycerides (TG) are emulsified by bile salts to form mixed micelles which are taken up by intestinal enterocytes and incorporated into chylomicrons (CM). CM are then secreted into the lymphatic system, and finally moves into the plasma. More...
hsa03320	PPAR signaling pathway	12	Peroxisome proliferator-activated receptors (PPARs) are nucl...... Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. More...

Genes shared at least 5 GO terms with APOA1 (count: 65)

Gene Symbol	Pathway Count	Pathway List
APOC3	23	extracellular region; phospholipid binding; extracellular space; G-protein coupled receptor signaling pathway; lipid metabolic process; cholesterol metabolic process; response to nutrient; triglyceride homeostasis; high-density lipoprotein particle receptor binding; lipase inhibitor activity; small molecule metabolic process; reverse cholesterol transport; response to drug; cholesterol homeostasis; lipoprotein metabolic process; high-density lipoprotein particle remodeling; spherical high-density lipoprotein particle; very-low-density lipoprotein particle; phospholipid efflux; cholesterol efflux; regulation of Cdc42 protein signal transduction; cholesterol binding; negative regulation of very-low-density lipoprotein particle remodeling;
ABCA1	20	phospholipid transporter activity; protein binding; phospholipid binding; plasma membrane; G-protein coupled receptor signaling pathway; lipid metabolic process; cholesterol metabolic process; phospholipid homeostasis; small molecule metabolic process; reverse cholesterol transport; cellular lipid metabolic process; cholesterol homeostasis; lipoprotein metabolic process; high-density lipoprotein particle assembly; phospholipid efflux; cholesterol efflux; regulation of Cdc42 protein signal transduction; endocytic vesicle; cholesterol transporter activity; cholesterol binding;
APOA4	18	extracellular region; endoplasmic reticulum lumen; extracellular space; lipid metabolic process; cholesterol metabolic process; phosphatidylcholine-sterol O-acyltransferase activator activity; small molecule metabolic process; reverse cholesterol transport; cholesterol homeostasis; lipoprotein metabolic process; high-density lipoprotein particle remodeling; high-density lipoprotein particle; very-low-density lipoprotein particle; phospholipid efflux; cholesterol efflux; regulation of intestinal cholesterol absorption; cholesterol transporter activity; positive regulation of cholesterol esterification;
SCARB1	14	endothelial cell proliferation; plasma membrane; lipid metabolic process; high-density lipoprotein particle binding; triglyceride homeostasis; cholesterol import; small molecule metabolic process; blood vessel endothelial cell migration; reverse cholesterol transport; cholesterol homeostasis; lipoprotein metabolic process; high-density lipoprotein particle clearance; high-density lipoprotein particle remodeling; cholesterol efflux;
APOC2	14	extracellular region; extracellular space; lipid metabolic process; triglyceride homeostasis; lipase inhibitor activity; small molecule metabolic process; reverse cholesterol transport; cholesterol homeostasis; lipoprotein metabolic process; high-density lipoprotein particle clearance; spherical high-density lipoprotein particle; very-low-density lipoprotein particle; phospholipid efflux; cholesterol efflux;
APOA5	13	extracellular region; protein binding; phospholipid binding; extracellular space; triglyceride homeostasis; small molecule metabolic process; cellular lipid metabolic process; cholesterol homeostasis; lipoprotein metabolic process; high-density lipoprotein particle; very-low-density lipoprotein particle; organ regeneration; enzyme binding;
LPL	10	extracellular region; protein binding; plasma membrane; extracellular space; lipid metabolic process; triglyceride homeostasis; small molecule metabolic process; response to drug; lipoprotein metabolic process; very-low-density lipoprotein particle;
ACHE	9	beta-amyloid binding; extracellular region; protein binding; endoplasmic reticulum lumen; plasma membrane; extracellular space; nucleus; phosphatidylcholine biosynthetic process; small molecule metabolic process;
VEGFA	8	platelet degranulation; extracellular region; protein binding; extracellular space; blood coagulation; identical protein binding; secretory granule; platelet activation;
NPC1	8	extracellular region; protein binding; cholesterol metabolic process; response to drug; cholesterol homeostasis; cholesterol efflux; cholesterol transport; cholesterol binding;
VEGFB	7	platelet degranulation; extracellular region; protein binding; extracellular space; blood coagulation; response to drug; platelet activation;
F7	7	extracellular region; endoplasmic reticulum lumen; plasma membrane; extracellular space; blood coagulation; response to estrogen stimulus; organ regeneration;
INS	7	extracellular region; protein binding; endoplasmic reticulum lumen; extracellular space; G-protein coupled receptor signaling pathway; small molecule metabolic process; secretory granule;
SERPINC1	7	extracellular region; protein binding; plasma membrane; extracellular space; response to nutrient; blood coagulation; negative regulation of inflammatory response;
SNCA	7	extracellular region; protein binding; phospholipid binding; plasma membrane; nucleus; response to drug; identical protein binding;
LIPG	7	extracellular space; lipid metabolic process; response to nutrient; phospholipid homeostasis; reverse cholesterol transport; cholesterol homeostasis; high-density lipoprotein particle remodeling;
ALDOA	6	platelet degranulation; extracellular region; blood coagulation; small molecule metabolic process; identical protein binding; platelet activation;
FN1	6	platelet degranulation; extracellular region; protein binding; extracellular space; blood coagulation; platelet activation;
HABP4	6	platelet degranulation; extracellular region; protein binding; nucleus; blood coagulation; platelet activation;
HSPA5	6	platelet degranulation; protein binding; endoplasmic reticulum lumen; nucleus; blood coagulation; platelet activation;
SERPING1	6	platelet degranulation; extracellular region; protein binding; extracellular space; blood coagulation; platelet activation;
F10	6	extracellular region; protein binding; phospholipid binding; endoplasmic reticulum lumen; plasma membrane; blood coagulation;
IGFBP2	6	extracellular region; protein binding; extracellular space; response to nutrient; response to drug; cytoplasmic vesicle;
ADORA2A	6	protein binding; plasma membrane; blood coagulation; negative regulation of inflammatory response; response to drug; enzyme binding;
ADRA2A	6	protein binding; plasma membrane; G-protein coupled receptor signaling pathway; blood coagulation; small molecule metabolic process; platelet activation;
ADRA2C	6	protein binding; plasma membrane; G-protein coupled receptor signaling pathway; blood coagulation; small molecule metabolic process; platelet activation;
APLP2	6	protein binding; plasma membrane; nucleus; G-protein coupled receptor signaling pathway; cholesterol metabolic process; identical protein binding;
ARRB1	6	protein binding; plasma membrane; nucleus; blood coagulation; cytoplasmic vesicle; platelet activation;
ARRB2	6	protein binding; plasma membrane; nucleus; blood coagulation; cytoplasmic vesicle; platelet activation;
CCND1	6	protein binding; nucleus; response to estrogen stimulus; response to drug; organ regeneration; enzyme binding;
PIK3CG	6	protein binding; plasma membrane; G-protein coupled receptor signaling pathway; blood coagulation; small molecule metabolic process; platelet activation;
PRKD1	6	protein binding; phospholipid binding; plasma membrane; nucleus; small molecule metabolic process; identical protein binding;
CUBN	6	plasma membrane; lipid metabolic process; cholesterol metabolic process; small molecule metabolic process; lipoprotein metabolic process; endocytic vesicle;
IL1RN	6	plasma membrane; extracellular space; nucleus; lipid metabolic process; response to drug; negative regulation of heterotypic cell-cell adhesion;
BCHE	5	beta-amyloid binding; extracellular region; endoplasmic reticulum lumen; extracellular space; enzyme binding;
CFL1	5	platelet degranulation; protein binding; nucleus; blood coagulation; platelet activation;
CTGF	5	extracellular region; plasma membrane; extracellular space; small molecule metabolic process; cellular lipid metabolic process;
F2RL2	5	extracellular region; protein binding; plasma membrane; blood coagulation; platelet activation;
GHR	5	extracellular region; protein binding; plasma membrane; extracellular space; nucleus;
PLA2G2A	5	extracellular region; phospholipid binding; extracellular space; small molecule metabolic process; secretory granule;
STX1A	5	extracellular region; protein binding; plasma membrane; small molecule metabolic process; secretory granule;
ABCG2	5	protein binding; plasma membrane; transmembrane transport; small molecule metabolic process; response to drug;
ADRA2B	5	protein binding; plasma membrane; G-protein coupled receptor signaling pathway; blood coagulation; platelet activation;
BCAR1	5	protein binding; plasma membrane; G-protein coupled receptor signaling pathway; blood coagulation; platelet activation;
DRD3	5	protein binding; plasma membrane; G-protein coupled receptor signaling pathway; response to drug; endocytic vesicle;
EHD1	5	protein binding; plasma membrane; blood coagulation; cholesterol homeostasis; endocytic vesicle;
EHD3	5	protein binding; plasma membrane; nucleus; blood coagulation; endocytic vesicle;
GATA6	5	protein binding; nucleus; blood coagulation; response to estrogen stimulus; response to drug;
LPAR1	5	protein binding; phospholipid binding; plasma membrane; G-protein coupled receptor signaling pathway; endocytic vesicle;
MAPK1	5	protein binding; nucleus; blood coagulation; response to estrogen stimulus; platelet activation;
MAPK7	5	protein binding; nucleus; negative regulation of response to cytokine stimulus; negative regulation of inflammatory response; negative regulation of heterotypic cell-cell adhesion;
MED1	5	protein binding; nucleus; small molecule metabolic process; cellular lipid metabolic process; organ regeneration;
NCOA6	5	protein binding; nucleus; small molecule metabolic process; cellular lipid metabolic process; enzyme binding;
NCOR1	5	protein binding; nucleus; small molecule metabolic process; cellular lipid metabolic process; cholesterol homeostasis;
NR5A1	5	protein binding; phospholipid binding; nucleus; adrenal gland development; enzyme binding;
OSBPL1A	5	protein binding; phospholipid binding; nucleus; cholesterol metabolic process; cholesterol binding;
PIK3R1	5	protein binding; plasma membrane; blood coagulation; small molecule metabolic process; platelet activation;
PLCG2	5	protein binding; phospholipid binding; plasma membrane; blood coagulation; platelet activation;
PRKCB	5	protein binding; plasma membrane; nucleus; blood coagulation; platelet activation;
SREBF1	5	protein binding; nucleus; lipid metabolic process; cholesterol metabolic process; response to drug;
STXBP3	5	protein binding; plasma membrane; nucleus; blood coagulation; platelet activation;
DGKH	5	phospholipid binding; plasma membrane; nucleus; blood coagulation; platelet activation;
MGLL	5	plasma membrane; lipid metabolic process; blood coagulation; small molecule metabolic process; platelet activation;
LPIN1	5	nucleus; phosphatidylcholine biosynthetic process; small molecule metabolic process; cellular lipid metabolic process; organ regeneration;
UGT1A1	5	response to nutrient; small molecule metabolic process; response to drug; organ regeneration; enzyme binding;

Genes shared at least 2 KEGG pathways with APOA1 (count: 3)

Gene Symbol	Pathway Count	Pathway List
APOA4	2	Fat digestion and absorption; Vitamin digestion and absorption;
PNLIP	2	Fat digestion and absorption; Vitamin digestion and absorption;
SCARB1	2	Fat digestion and absorption; Vitamin digestion and absorption;

View in gBrowse

Region: chr11:116706467..116708666 View in gBrowse