ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	STX18
Symbol Alias	Ufe1
Approved Name	syntaxin 18
Location	4
Position	chr4:4417469-4544073, -
External Links	HGNC: 15942 Entrez Gene: 53407 Ensembl: ENSG00000168818 UCSC: uc003gic.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048193	Golgi vesicle transport	Biological Process		49

GO terms by database search (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000139	Golgi membrane	Cellular Component		95
GO:0005515	protein binding	Molecular Function	IPI[15272311]	910
GO:0005484	SNAP receptor activity	Molecular Function		13
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005783	endoplasmic reticulum	Cellular Component	TAS[10788491]	100
GO:0006888	ER to Golgi vesicle-mediated transport	Biological Process	TAS[10788491]	24
GO:0006886	intracellular protein transport	Biological Process		43
GO:0016021	integral to membrane	Cellular Component		845

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04145	Phagosome	32	Phagocytosis is the process of taking in relatively large pa...... Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes. More...
hsa04130	SNARE interactions in vesicular transport	20

Genes shared at least 5 GO terms with STX18 (count: 18)

Gene Symbol	Pathway Count	Pathway List
TMED10	7	protein binding; endoplasmic reticulum membrane; endoplasmic reticulum; ER to Golgi vesicle-mediated transport; intracellular protein transport; Golgi vesicle transport; integral to membrane;
BET1	6	Golgi membrane; protein binding; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport; Golgi vesicle transport; integral to membrane;
ERGIC1	6	Golgi membrane; protein binding; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport; Golgi vesicle transport; integral to membrane;
LMAN1	6	Golgi membrane; protein binding; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport; Golgi vesicle transport; integral to membrane;
SEC22B	6	Golgi membrane; protein binding; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport; Golgi vesicle transport; integral to membrane;
STX16	6	Golgi membrane; protein binding; SNAP receptor activity; intracellular protein transport; Golgi vesicle transport; integral to membrane;
STX5	6	Golgi membrane; SNAP receptor activity; endoplasmic reticulum; ER to Golgi vesicle-mediated transport; intracellular protein transport; integral to membrane;
STX6	6	Golgi membrane; protein binding; SNAP receptor activity; intracellular protein transport; Golgi vesicle transport; integral to membrane;
TMED2	6	protein binding; endoplasmic reticulum membrane; endoplasmic reticulum; ER to Golgi vesicle-mediated transport; intracellular protein transport; integral to membrane;
USE1	6	protein binding; endoplasmic reticulum membrane; endoplasmic reticulum; ER to Golgi vesicle-mediated transport; Golgi vesicle transport; integral to membrane;
GOSR1	5	Golgi membrane; SNAP receptor activity; ER to Golgi vesicle-mediated transport; Golgi vesicle transport; integral to membrane;
LMAN2L	5	Golgi membrane; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport; Golgi vesicle transport; integral to membrane;
SREBF1	5	Golgi membrane; protein binding; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane;
TAPBP	5	Golgi membrane; protein binding; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane;
UNC93B1	5	Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum; intracellular protein transport; integral to membrane;
YKT6	5	Golgi membrane; SNAP receptor activity; endoplasmic reticulum; ER to Golgi vesicle-mediated transport; Golgi vesicle transport;
ZW10	5	protein binding; endoplasmic reticulum membrane; endoplasmic reticulum; ER to Golgi vesicle-mediated transport; Golgi vesicle transport;
SEC22C	5	endoplasmic reticulum membrane; endoplasmic reticulum; ER to Golgi vesicle-mediated transport; Golgi vesicle transport; integral to membrane;

Genes shared at least 2 KEGG pathways with STX18 (count: 2)

Gene Symbol	Pathway Count	Pathway List
SEC22B	2	Phagosome; SNARE interactions in vesicular transport;
STX7	2	Phagosome; SNARE interactions in vesicular transport;

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Region: chr4:4417469..4544073 View in gBrowse