ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ZW10
Symbol Alias	KNTC1AP
Approved Name	ZW10, kinetochore associated, homolog (Drosophila)
Previous Name	ZW10 (Drosophila) homolog, centromere/kinetochore protein
Location	11q23
Position	chr11:113603909-113644425, -
External Links	HGNC: 13194 Entrez Gene: 9183 Ensembl: ENSG00000086827 UCSC: uc001poe.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 25)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048193	Golgi vesicle transport	Biological Process		49

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051301	cell division	Biological Process		58
GO:0034501	protein localization to kinetochore	Biological Process	IMP[19468067]	1
GO:0005515	protein binding	Molecular Function	IPI[16732327]	910
GO:0005634	nucleus	Cellular Component	IDA[15485811]	770
GO:0000777	condensed chromosome kinetochore	Cellular Component		13
GO:0000922	spindle pole	Cellular Component	IDA[11146660]	22
GO:0005828	kinetochore microtubule	Cellular Component	IDA[11146660]	3
GO:0005829	cytosol	Cellular Component		447
GO:0005783	endoplasmic reticulum	Cellular Component	IDA[15029241]	100
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0007080	mitotic metaphase plate congression	Biological Process	IMP[19468067]	3
GO:0007093	mitotic cell cycle checkpoint	Biological Process	IDA[11146660]	1
GO:0006461	protein complex assembly	Biological Process	IDA[11146660]	28
GO:0006888	ER to Golgi vesicle-mediated transport	Biological Process	IMP[15029241]	24
GO:0015031	protein transport	Biological Process		75
GO:0019237	centromeric DNA binding	Molecular Function	TAS[9700164]	3
GO:0007096	regulation of exit from mitosis	Biological Process	IDA[11146660]	1
GO:0007126	meiosis	Biological Process	TAS[9298984]	11
GO:0000087	M phase of mitotic cell cycle	Biological Process		19
GO:0000070	mitotic sister chromatid segregation	Biological Process	IDA[11146660]	4
GO:0000236	mitotic prometaphase	Biological Process		17
GO:0000132	establishment of mitotic spindle orientation	Biological Process	IMP[19468067]	7
GO:0000776	kinetochore	Cellular Component	IDA[11682612]	15
GO:0000278	mitotic cell cycle	Biological Process		63

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ZW10 (count: 33)

Gene Symbol	Pathway Count	Pathway List
KIF2C	10	cell division; protein binding; nucleus; condensed chromosome kinetochore; cytosol; centromeric DNA binding; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
SMC1A	10	cell division; protein binding; nucleus; condensed chromosome kinetochore; meiosis; M phase of mitotic cell cycle; mitotic sister chromatid segregation; mitotic prometaphase; kinetochore; mitotic cell cycle;
CLASP1	9	cell division; protein binding; condensed chromosome kinetochore; kinetochore microtubule; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
NDE1	9	cell division; protein binding; condensed chromosome kinetochore; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; establishment of mitotic spindle orientation; kinetochore; mitotic cell cycle;
CENPC1	8	cell division; nucleus; condensed chromosome kinetochore; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
CLASP2	8	cell division; protein binding; condensed chromosome kinetochore; kinetochore microtubule; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
SMC3	8	cell division; protein binding; nucleus; spindle pole; meiosis; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
PAFAH1B1	8	protein binding; nucleus; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; establishment of mitotic spindle orientation; kinetochore; mitotic cell cycle;
PLK1	8	protein binding; nucleus; spindle pole; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
CKAP5	7	cell division; protein binding; spindle pole; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
NUMA1	7	cell division; protein binding; nucleus; spindle pole; cytosol; establishment of mitotic spindle orientation; mitotic cell cycle;
INCENP	7	protein binding; condensed chromosome kinetochore; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
MAPRE1	6	cell division; protein binding; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
USE1	6	Golgi vesicle transport; protein binding; endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport; protein transport;
TUBGCP2	6	protein binding; nucleus; spindle pole; cytosol; protein complex assembly; mitotic cell cycle;
XPO1	6	protein binding; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
CCND1	5	cell division; protein binding; nucleus; cytosol; mitotic cell cycle;
CENPW	5	cell division; protein binding; condensed chromosome kinetochore; kinetochore; mitotic cell cycle;
CEP164	5	cell division; protein binding; nucleus; cytosol; mitotic cell cycle;
LATS2	5	cell division; protein binding; nucleus; spindle pole; cytosol;
PSRC1	5	cell division; protein binding; spindle pole; cytosol; mitotic metaphase plate congression;
PTTG1	5	cell division; protein binding; nucleus; cytosol; mitotic cell cycle;
BET1	5	Golgi vesicle transport; protein binding; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport; protein transport;
SEC22B	5	Golgi vesicle transport; protein binding; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport; protein transport;
SEC22C	5	Golgi vesicle transport; endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport; protein transport;
STX18	5	Golgi vesicle transport; protein binding; endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport;
TMED10	5	Golgi vesicle transport; protein binding; endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport;
YKT6	5	Golgi vesicle transport; cytosol; endoplasmic reticulum; ER to Golgi vesicle-mediated transport; protein transport;
APC	5	protein binding; nucleus; cytosol; protein complex assembly; kinetochore;
CDK5RAP2	5	protein binding; spindle pole; cytosol; establishment of mitotic spindle orientation; mitotic cell cycle;
KIF23	5	protein binding; nucleus; cytosol; M phase of mitotic cell cycle; mitotic cell cycle;
CENPL	5	nucleus; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
CENPN	5	condensed chromosome kinetochore; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;

Genes shared at least 2 KEGG pathways with ZW10 (count: 0)

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Region: chr11:113603909..113644425 View in gBrowse