Gene Report
Basic Info
Approved Symbol |
TNFRSF11A
|
Symbol Alias |
RANK, CD265 |
Approved Name |
tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
Previous Name |
tumor necrosis factor receptor superfamily, member 11a, activator of NFKB |
Location |
18q22.1 |
Position |
chr18:59992520-60054899, + |
External Links |
HGNC: 11908
Entrez Gene: 8792
UCSC: uc002lin.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by CNV |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 1)
Gene related other variant (count: 0)
Gene related regions (count: 0)
Gene related GO terms (count: 27)
Gene related KEGG pathways (count: 3)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04380 |
Osteoclast differentiation |
25 |
The osteoclasts, multinucleared cells originating from the h......
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
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|
hsa05323 |
Rheumatoid arthritis |
17 |
Rheumatoid arthritis (RA) is a chronic autoimmune joint dise......
Rheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune system elevates pro-inflammatory cytokines and chemokines levels, which can promote synovial angiogenesis and leukocyte infiltration. The synovium forms a hyperplastic pannus with infiltrated macrophage-like and fibroblast-like synoviocytes and invades joints by secreting proteinases and inducing osteoclast differentiation.
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|
hsa04060 |
Cytokine-cytokine receptor interaction |
38 |
Cytokines are soluble extracellular proteins or glycoprotein......
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
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|
Genes shared at least 5 GO terms with TNFRSF11A (count: 8)
Genes shared at least 2 KEGG pathways with TNFRSF11A (count: 7)
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