ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TNFRSF11A
Symbol Alias	RANK, CD265
Approved Name	tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Previous Name	tumor necrosis factor receptor superfamily, member 11a, activator of NFKB
Location	18q22.1
Position	chr18:59992520-60054899, +
External Links	HGNC: 11908 Entrez Gene: 8792 UCSC: uc002lin.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_196	chr18:58154336-58346849 (NCBI Build 35 (hg17))	192514	18q21.33	Duplication	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion	Biological Process	ISS[19940926]	1
GO:0070555	response to interleukin-1	Biological Process	ISS[19940926]	6
GO:0060086	circadian temperature homeostasis	Biological Process	ISS[19940926]	1
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IDA[9367155]; IMP[12296995]	27
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	Biological Process	IDA[12296995]; ISS[19940926]	11
GO:0046872	metal ion binding	Molecular Function		170
GO:0043507	positive regulation of JUN kinase activity	Biological Process	IMP[12296995]	6
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	RCA[19641626]	27
GO:0034612	response to tumor necrosis factor	Biological Process	ISS[19940926]	2
GO:0034097	response to cytokine stimulus	Biological Process	IMP[18606301]	9
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	ISS[19940926]	6
GO:0032496	response to lipopolysaccharide	Biological Process	ISS[19940926]	22
GO:0030316	osteoclast differentiation	Biological Process	IMP[18606301]	3
GO:0019955	cytokine binding	Molecular Function	IPI[9367155]	4
GO:0016021	integral to membrane	Cellular Component		845
GO:0009897	external side of plasma membrane	Cellular Component	IDA[9367155]	34
GO:0007267	cell-cell signaling	Biological Process	TAS[9367155]	38
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS[9367155]	69
GO:0005515	protein binding	Molecular Function	IPI[15750601]	910
GO:0007165	signal transduction	Biological Process	TAS[9367155]	171
GO:0004888	transmembrane signaling receptor activity	Molecular Function	IDA[9367155]	20
GO:0005031	tumor necrosis factor-activated receptor activity	Molecular Function	ISS[19940926]	2
GO:0002548	monocyte chemotaxis	Biological Process	NAS[15248232]	2
GO:0004872	receptor activity	Molecular Function	TAS[9367155]	36
GO:0002250	adaptive immune response	Biological Process	IMP[18606301]	5
GO:0071847	TNFSF11-mediated signaling pathway	Biological Process	IMP[18606301]	1
GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	Biological Process	IMP[18606301]	1

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04380	Osteoclast differentiation	25	The osteoclasts, multinucleared cells originating from the h...... The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast. More...
hsa05323	Rheumatoid arthritis	17	Rheumatoid arthritis (RA) is a chronic autoimmune joint dise...... Rheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune system elevates pro-inflammatory cytokines and chemokines levels, which can promote synovial angiogenesis and leukocyte infiltration. The synovium forms a hyperplastic pannus with infiltrated macrophage-like and fibroblast-like synoviocytes and invades joints by secreting proteinases and inducing osteoclast differentiation. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

Genes shared at least 5 GO terms with TNFRSF11A (count: 8)

Gene Symbol	Pathway Count	Pathway List
TLR4	7	positive regulation of NF-kappaB transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to lipopolysaccharide; external side of plasma membrane; protein binding; transmembrane signaling receptor activity; receptor activity;
EDA2R	6	positive regulation of NF-kappaB transcription factor activity; tumor necrosis factor-mediated signaling pathway; integral to membrane; protein binding; tumor necrosis factor-activated receptor activity; receptor activity;
IL6	6	positive regulation of NF-kappaB transcription factor activity; positive regulation of sequence-specific DNA binding transcription factor activity; response to lipopolysaccharide; external side of plasma membrane; positive regulation of cell proliferation; monocyte chemotaxis;
RELA	5	response to interleukin-1; positive regulation of NF-kappaB transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cell proliferation; protein binding;
PRKD1	5	positive regulation of NF-kappaB transcription factor activity; metal ion binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein binding; signal transduction;
PYCARD	5	positive regulation of NF-kappaB transcription factor activity; positive regulation of sequence-specific DNA binding transcription factor activity; tumor necrosis factor-mediated signaling pathway; protein binding; signal transduction;
TNFSF18	5	positive regulation of NF-kappaB transcription factor activity; tumor necrosis factor-mediated signaling pathway; integral to membrane; cell-cell signaling; signal transduction;
MAVS	5	positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; integral to membrane; protein binding; signal transduction;

Genes shared at least 2 KEGG pathways with TNFRSF11A (count: 7)

Gene Symbol	Pathway Count	Pathway List
IFNGR1	2	Osteoclast differentiation; Cytokine-cytokine receptor interaction;
TGFBR1	2	Osteoclast differentiation; Cytokine-cytokine receptor interaction;
CXCL12	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;
IL18	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;
IL6	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;
VEGFA	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;
VEGFB	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;

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Region: chr18:59992520..60054899 View in gBrowse