ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CXCL12
Previous Symbol	SDF1A, SDF1B, SDF1
Symbol Alias	SCYB12, SDF-1a, SDF-1b, PBSF, TLSF-a, TLSF-b, TPAR1
Approved Name	chemokine (C-X-C motif) ligand 12
Previous Name	stromal cell-derived factor 1
Location	10q11.1
Position	chr10:44865605-44881941, -
External Links	HGNC: 10672 Entrez Gene: 6387 Ensembl: ENSG00000107562 UCSC: uc001jbh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 29)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051493	regulation of cytoskeleton organization	Biological Process		32

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006874	cellular calcium ion homeostasis	Biological Process	TAS[10772939]	16
GO:0006935	chemotaxis	Biological Process	TAS[10620615]	15
GO:0006955	immune response	Biological Process		45
GO:0007155	cell adhesion	Biological Process	TAS[10198043]	86
GO:0007165	signal transduction	Biological Process	TAS[10491003]	171
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[8752280]	72
GO:0007281	germ cell development	Biological Process		7
GO:0007420	brain development	Biological Process		33
GO:0008009	chemokine activity	Molecular Function		4
GO:0008015	blood circulation	Biological Process	TAS[10772939]	12
GO:0008045	motor neuron axon guidance	Biological Process		7
GO:0008064	regulation of actin polymerization or depolymerization	Biological Process	TAS[10570282]	3
GO:0008083	growth factor activity	Molecular Function		25
GO:0008354	germ cell migration	Biological Process		2
GO:0009615	response to virus	Biological Process	TAS[10772939]	21
GO:0009897	external side of plasma membrane	Cellular Component		34
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0042098	T cell proliferation	Biological Process		4
GO:0050930	induction of positive chemotaxis	Biological Process		6
GO:0045236	CXCR chemokine receptor binding	Molecular Function		1
GO:0070098	chemokine-mediated signaling pathway	Biological Process		3
GO:2000107	negative regulation of leukocyte apoptotic process	Biological Process	IDA[15059845]	2
GO:0090026	positive regulation of monocyte chemotaxis	Biological Process	IDA[18802065]	1
GO:0001569	patterning of blood vessels	Biological Process		7
GO:0005615	extracellular space	Cellular Component		126
GO:0005576	extracellular region	Cellular Component		240
GO:0005102	receptor binding	Molecular Function	TAS[10438529]	61
GO:0001667	ameboidal cell migration	Biological Process		3

Gene related KEGG pathways (count: 6)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05323	Rheumatoid arthritis	17	Rheumatoid arthritis (RA) is a chronic autoimmune joint dise...... Rheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune system elevates pro-inflammatory cytokines and chemokines levels, which can promote synovial angiogenesis and leukocyte infiltration. The synovium forms a hyperplastic pannus with infiltrated macrophage-like and fibroblast-like synoviocytes and invades joints by secreting proteinases and inducing osteoclast differentiation. More...
hsa04360	Axon guidance	25	Axon guidance represents a key stage in the formation of neu...... Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. More...
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04670	Leukocyte transendothelial migration	22	Leukocyte migaration from the blood into tissues is vital fo...... Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04672	Intestinal immune network for IgA production	5	The intestine is the largest lymphoid tissue in the body. On...... The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes. More...

Genes shared at least 5 GO terms with CXCL12 (count: 14)

Gene Symbol	Pathway Count	Pathway List
C5	7	cellular calcium ion homeostasis; chemotaxis; G-protein coupled receptor signaling pathway; chemokine activity; extracellular space; extracellular region; receptor binding;
CCL19	7	cellular calcium ion homeostasis; immune response; chemokine activity; response to virus; negative regulation of leukocyte apoptotic process; extracellular space; extracellular region;
NTF3	6	signal transduction; brain development; growth factor activity; induction of positive chemotaxis; extracellular region; receptor binding;
VEGFA	6	growth factor activity; negative regulation of apoptotic process; induction of positive chemotaxis; patterning of blood vessels; extracellular space; extracellular region;
CCL27	5	chemotaxis; immune response; chemokine activity; extracellular space; extracellular region;
CCR5	5	chemotaxis; immune response; G-protein coupled receptor signaling pathway; external side of plasma membrane; chemokine-mediated signaling pathway;
SPN	5	chemotaxis; immune response; signal transduction; external side of plasma membrane; extracellular space;
SEMA4D	5	immune response; cell adhesion; negative regulation of apoptotic process; extracellular space; receptor binding;
TNC	5	cell adhesion; signal transduction; extracellular space; extracellular region; receptor binding;
GDNF	5	signal transduction; growth factor activity; negative regulation of apoptotic process; extracellular region; receptor binding;
TNFSF4	5	signal transduction; response to virus; T cell proliferation; extracellular space; receptor binding;
FGF10	5	growth factor activity; negative regulation of apoptotic process; induction of positive chemotaxis; extracellular space; extracellular region;
IL6	5	growth factor activity; external side of plasma membrane; negative regulation of apoptotic process; extracellular space; extracellular region;
VEGFB	5	growth factor activity; negative regulation of apoptotic process; induction of positive chemotaxis; extracellular space; extracellular region;

Genes shared at least 2 KEGG pathways with CXCL12 (count: 24)

Gene Symbol	Pathway Count	Pathway List
IL6	3	Rheumatoid arthritis; Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production;
ROCK2	3	Axon guidance; Chemokine signaling pathway; Leukocyte transendothelial migration;
CCL27	3	Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production;
HLA-DRB1	2	Rheumatoid arthritis; Intestinal immune network for IgA production;
IL18	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;
ITGAL	2	Rheumatoid arthritis; Leukocyte transendothelial migration;
TNFRSF11A	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;
VEGFA	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;
VEGFB	2	Rheumatoid arthritis; Cytokine-cytokine receptor interaction;
GSK3B	2	Axon guidance; Chemokine signaling pathway;
MAPK1	2	Axon guidance; Chemokine signaling pathway;
MAPK3	2	Axon guidance; Chemokine signaling pathway;
PAK1	2	Axon guidance; Chemokine signaling pathway;
BCAR1	2	Chemokine signaling pathway; Leukocyte transendothelial migration;
CCL19	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CCR5	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR1	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR2	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR5	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
ITK	2	Chemokine signaling pathway; Leukocyte transendothelial migration;
PIK3CG	2	Chemokine signaling pathway; Leukocyte transendothelial migration;
PIK3R1	2	Chemokine signaling pathway; Leukocyte transendothelial migration;
PRKCB	2	Chemokine signaling pathway; Leukocyte transendothelial migration;
TNFRSF13B	2	Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production;

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Region: chr10:44865605..44881941 View in gBrowse