ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CDIPT
Symbol Alias	PIS1, PIS
Approved Name	CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Previous Name	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
Name Alias	phosphatidylinositol synthase
Location	16p12.1
Position	chr16:29869678-29875055, -
External Links	HGNC: 1769 Entrez Gene: 10423 Ensembl: ENSG00000103502 UCSC: uc002dum.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 4)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_16	chr16:29563594-30367556 (NCBI Build 36.1 (hg18))	803963	16p11.2	Loss
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain
CNV_Jarick[2012]_35	chr16:29554843-30085308 (NCBI36 / hg18)	530466	16p11.2	del

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000139	Golgi membrane	Cellular Component		95
GO:0003881	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity	Molecular Function	IDA[9407135]	1
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005886	plasma membrane	Cellular Component		772
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0006661	phosphatidylinositol biosynthetic process	Biological Process	IDA[9407135]	12
GO:0016021	integral to membrane	Cellular Component		845
GO:0046474	glycerophospholipid biosynthetic process	Biological Process		30
GO:0046341	CDP-diacylglycerol metabolic process	Biological Process		1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0043178	alcohol binding	Molecular Function		1
GO:0030246	carbohydrate binding	Molecular Function		28
GO:0030145	manganese ion binding	Molecular Function		10
GO:0019992	diacylglycerol binding	Molecular Function		2

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa01100	Metabolic pathways	237
hsa00562	Inositol phosphate metabolism	14
hsa04070	Phosphatidylinositol signaling system	19
hsa00564	Glycerophospholipid metabolism	22

Genes shared at least 5 GO terms with CDIPT (count: 16)

Gene Symbol	Pathway Count	Pathway List
LPCAT1	6	Golgi membrane; endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;
PNPLA8	6	Golgi membrane; endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;
TPTE2	6	Golgi membrane; endoplasmic reticulum membrane; phospholipid metabolic process; phosphatidylinositol biosynthetic process; integral to membrane; small molecule metabolic process;
PLD1	5	Golgi membrane; endoplasmic reticulum membrane; phospholipid metabolic process; glycerophospholipid biosynthetic process; small molecule metabolic process;
SMPD4	5	Golgi membrane; endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process;
DGAT2	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;
LPCAT4	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;
MBOAT1	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;
MBOAT2	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;
MGLL	5	endoplasmic reticulum membrane; plasma membrane; phospholipid metabolic process; glycerophospholipid biosynthetic process; small molecule metabolic process;
PEMT	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;
PLD2	5	endoplasmic reticulum membrane; plasma membrane; phospholipid metabolic process; glycerophospholipid biosynthetic process; small molecule metabolic process;
PLD3	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;
PNPLA3	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;
STS	5	endoplasmic reticulum membrane; plasma membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process;
SLC44A1	5	plasma membrane; phospholipid metabolic process; integral to membrane; glycerophospholipid biosynthetic process; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with CDIPT (count: 32)

Gene Symbol	Pathway Count	Pathway List
DGKH	3	Metabolic pathways; Phosphatidylinositol signaling system; Glycerophospholipid metabolism;
INPP5A	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPPL1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
IPPK	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4K2B	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4KA	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PIK3C3	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB2	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB3	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCD1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCD4	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCE1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCG2	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
CHKA	2	Metabolic pathways; Glycerophospholipid metabolism;
GPAT2	2	Metabolic pathways; Glycerophospholipid metabolism;
LPCAT1	2	Metabolic pathways; Glycerophospholipid metabolism;
LPCAT4	2	Metabolic pathways; Glycerophospholipid metabolism;
MBOAT1	2	Metabolic pathways; Glycerophospholipid metabolism;
MBOAT2	2	Metabolic pathways; Glycerophospholipid metabolism;
PEMT	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G10	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G1B	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2A	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2D	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2E	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G3	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G4B	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G5	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G6	2	Metabolic pathways; Glycerophospholipid metabolism;
PLD1	2	Metabolic pathways; Glycerophospholipid metabolism;
PLD2	2	Metabolic pathways; Glycerophospholipid metabolism;
PIK3CG	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;

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Region: chr16:29869678..29875055 View in gBrowse