ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	INPPL1
Symbol Alias	SHIP2
Approved Name	inositol polyphosphate phosphatase-like 1
Name Alias	51C protein
Location	11q23
Position	chr11:71935825-71950191, +
External Links	HGNC: 6080 Entrez Gene: 3636 Ensembl: ENSG00000165458 UCSC: uc001osf.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 34)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0097178	ruffle assembly	Biological Process		1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	Biological Process		3
GO:0046854	phosphatidylinositol phosphorylation	Biological Process		5
GO:0046627	negative regulation of insulin receptor signaling pathway	Biological Process		5
GO:0042169	SH2 domain binding	Molecular Function	IPI[5668240]	7
GO:0032957	inositol trisphosphate metabolic process	Biological Process		1
GO:0043407	negative regulation of MAP kinase activity	Biological Process		7
GO:0042493	response to drug	Biological Process		68
GO:0030479	actin cortical patch	Cellular Component		1
GO:0032868	response to insulin stimulus	Biological Process		11
GO:0017124	SH3 domain binding	Molecular Function		22
GO:0030027	lamellipodium	Cellular Component		27
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	Biological Process		3
GO:0010977	negative regulation of neuron projection development	Biological Process		4
GO:0009791	post-embryonic development	Biological Process		16
GO:0010629	negative regulation of gene expression	Biological Process		13
GO:0008156	negative regulation of DNA replication	Biological Process		3
GO:0008285	negative regulation of cell proliferation	Biological Process		59
GO:0007155	cell adhesion	Biological Process	TAS[15668240]	86
GO:0007420	brain development	Biological Process		33
GO:0006897	endocytosis	Biological Process	IMP[15668240]	23
GO:0007015	actin filament organization	Biological Process	IMP[15668240]	12
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0006661	phosphatidylinositol biosynthetic process	Biological Process		12
GO:0006006	glucose metabolic process	Biological Process		19
GO:0005886	plasma membrane	Cellular Component		772
GO:0005829	cytosol	Cellular Component		447
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005737	cytoplasm	Cellular Component		690
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	Molecular Function		3
GO:0005515	protein binding	Molecular Function		910
GO:0004445	inositol-polyphosphate 5-phosphatase activity	Molecular Function		2
GO:0003779	actin binding	Molecular Function		46

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa01100	Metabolic pathways	237
hsa00562	Inositol phosphate metabolism	14
hsa04070	Phosphatidylinositol signaling system	19

Genes shared at least 5 GO terms with INPPL1 (count: 56)

Gene Symbol	Pathway Count	Pathway List
PIK3CG	8	small molecule metabolic process; endocytosis; phospholipid metabolic process; phosphatidylinositol biosynthetic process; plasma membrane; cytosol; cytoplasm; protein binding;
SNCA	8	response to drug; negative regulation of platelet-derived growth factor receptor signaling pathway; phospholipid metabolic process; plasma membrane; cytosol; Golgi apparatus; cytoplasm; protein binding;
PIK3R1	7	small molecule metabolic process; phosphatidylinositol phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; plasma membrane; cytosol; protein binding;
PRKD1	7	small molecule metabolic process; phospholipid metabolic process; plasma membrane; cytosol; Golgi apparatus; cytoplasm; protein binding;
BCAR1	7	SH3 domain binding; cell adhesion; actin filament organization; plasma membrane; cytosol; cytoplasm; protein binding;
APC	7	lamellipodium; negative regulation of cell proliferation; cell adhesion; plasma membrane; cytosol; cytoplasm; protein binding;
CRYAB	7	negative regulation of gene expression; glucose metabolic process; plasma membrane; cytosol; Golgi apparatus; cytoplasm; protein binding;
ACHE	6	small molecule metabolic process; cell adhesion; phospholipid metabolic process; plasma membrane; Golgi apparatus; protein binding;
ENPP7	6	small molecule metabolic process; negative regulation of DNA replication; negative regulation of cell proliferation; phospholipid metabolic process; plasma membrane; Golgi apparatus;
MTMR2	6	small molecule metabolic process; phospholipid metabolic process; phosphatidylinositol biosynthetic process; cytosol; cytoplasm; protein binding;
WASL	6	small molecule metabolic process; lamellipodium; plasma membrane; cytosol; protein binding; actin binding;
GRB10	6	negative regulation of insulin receptor signaling pathway; response to insulin stimulus; plasma membrane; cytosol; cytoplasm; protein binding;
RELA	6	negative regulation of insulin receptor signaling pathway; response to drug; response to insulin stimulus; cytosol; cytoplasm; protein binding;
GSK3B	6	negative regulation of MAP kinase activity; response to drug; plasma membrane; cytosol; cytoplasm; protein binding;
ADAM17	6	response to drug; SH3 domain binding; cell adhesion; plasma membrane; cytoplasm; protein binding;
TSC1	6	response to insulin stimulus; lamellipodium; negative regulation of cell proliferation; cytosol; cytoplasm; protein binding;
ILK	6	SH3 domain binding; lamellipodium; plasma membrane; cytosol; cytoplasm; protein binding;
CTNND1	6	lamellipodium; cell adhesion; plasma membrane; cytosol; cytoplasm; protein binding;
NF2	6	lamellipodium; negative regulation of DNA replication; negative regulation of cell proliferation; plasma membrane; cytoplasm; protein binding;
ALDOA	5	small molecule metabolic process; actin filament organization; glucose metabolic process; cytosol; actin binding;
CTGF	5	small molecule metabolic process; negative regulation of gene expression; plasma membrane; cytosol; Golgi apparatus;
FABP6	5	small molecule metabolic process; negative regulation of cell proliferation; cytosol; Golgi apparatus; cytoplasm;
FBP1	5	small molecule metabolic process; glucose metabolic process; cytosol; cytoplasm; protein binding;
GSTP1	5	small molecule metabolic process; negative regulation of MAP kinase activity; cytosol; cytoplasm; protein binding;
LPL	5	small molecule metabolic process; response to drug; phospholipid metabolic process; plasma membrane; protein binding;
NUP62	5	small molecule metabolic process; SH2 domain binding; negative regulation of cell proliferation; cytoplasm; protein binding;
PI4K2B	5	small molecule metabolic process; phospholipid metabolic process; phosphatidylinositol biosynthetic process; cytosol; cytoplasm;
PI4KA	5	small molecule metabolic process; phospholipid metabolic process; phosphatidylinositol biosynthetic process; cytosol; protein binding;
PIK3C3	5	small molecule metabolic process; phospholipid metabolic process; phosphatidylinositol biosynthetic process; cytosol; protein binding;
STAB2	5	small molecule metabolic process; cell adhesion; endocytosis; plasma membrane; cytoplasm;
PRKCB	5	negative regulation of insulin receptor signaling pathway; plasma membrane; cytosol; cytoplasm; protein binding;
CAV3	5	negative regulation of MAP kinase activity; endocytosis; actin filament organization; plasma membrane; protein binding;
PTPRJ	5	negative regulation of MAP kinase activity; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of cell proliferation; plasma membrane; protein binding;
TJP1	5	response to drug; plasma membrane; cytosol; cytoplasm; protein binding;
SORT1	5	response to insulin stimulus; endocytosis; plasma membrane; Golgi apparatus; cytoplasm;
BAIAP2	5	SH3 domain binding; plasma membrane; cytosol; cytoplasm; protein binding;
CBL	5	SH3 domain binding; plasma membrane; cytosol; cytoplasm; protein binding;
GJA1	5	SH3 domain binding; negative regulation of cell proliferation; plasma membrane; Golgi apparatus; protein binding;
CCDC88A	5	lamellipodium; plasma membrane; cytosol; Golgi apparatus; actin binding;
CORO1A	5	lamellipodium; actin filament organization; plasma membrane; cytoplasm; protein binding;
RDX	5	lamellipodium; plasma membrane; cytoplasm; protein binding; actin binding;
MEN1	5	negative regulation of cell proliferation; brain development; cytosol; cytoplasm; protein binding;
NCK2	5	negative regulation of cell proliferation; actin filament organization; cytosol; cytoplasm; protein binding;
ARRB2	5	brain development; plasma membrane; cytosol; cytoplasm; protein binding;
CDK5RAP2	5	brain development; cytosol; Golgi apparatus; cytoplasm; protein binding;
NCK1	5	actin filament organization; plasma membrane; cytosol; cytoplasm; protein binding;
PLCE1	5	phospholipid metabolic process; plasma membrane; cytosol; cytoplasm; protein binding;
ARAP1	5	plasma membrane; cytosol; Golgi apparatus; phosphatidylinositol-3,4,5-trisphosphate binding; protein binding;
ARPC2	5	plasma membrane; Golgi apparatus; cytoplasm; protein binding; actin binding;
CLASP2	5	plasma membrane; cytosol; Golgi apparatus; cytoplasm; protein binding;
FLNC	5	plasma membrane; cytosol; cytoplasm; protein binding; actin binding;
GAB2	5	plasma membrane; cytosol; cytoplasm; phosphatidylinositol-3,4,5-trisphosphate binding; protein binding;
PAK1	5	plasma membrane; cytosol; Golgi apparatus; cytoplasm; protein binding;
PDE2A	5	plasma membrane; cytosol; Golgi apparatus; cytoplasm; protein binding;
PRKG1	5	plasma membrane; cytosol; Golgi apparatus; cytoplasm; protein binding;
WWOX	5	plasma membrane; cytosol; Golgi apparatus; cytoplasm; protein binding;

Genes shared at least 2 KEGG pathways with INPPL1 (count: 14)

Gene Symbol	Pathway Count	Pathway List
CDIPT	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPP5A	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
IPPK	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4K2B	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4KA	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PIK3C3	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB2	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB3	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCD1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCD4	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCE1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCG2	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
DGKH	2	Metabolic pathways; Phosphatidylinositol signaling system;
PIK3CG	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;

View in gBrowse

Region: chr11:71935825..71950191 View in gBrowse