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- Data Summary
Gene Report
Approved Symbol | MAOB |
---|---|
Approved Name | monoamine oxidase B |
Location | Xp11.4-p11.3 |
Position | chrX:43625857-43741721, - |
External Links |
HGNC: 6834 Entrez Gene: 4129 Ensembl: ENSG00000069535 UCSC: uc004dfz.3 |
No. of Studies | 6 (significant: 2; non-significant: 4; trend: 0) |
Source | Literature-origin; Mapped by LD-proxy; Mapped by literature SNP |
Reference | Statistical Values/Author Comments | Result of Statistical Analysis |
---|---|---|
Ribases M, 2009(b) | Haplotype analysis: P-value=0.0029, OR=1.90 for adult ADHD, specifically associated in the adult ADHD sample. | Significant |
Li J, 2008 | haplotype TCA P-value=0.003, X2=8.71, haplotype CTA P-value=6.978E-19, X2=78.77, haplotype TCG P-value=1.620E-6, X2=23.00, haplotype CTG P-value=6.220E-11, X2=42.75, provides the strongest evidence for the involvement of MAOB gene | Significant |
Brookes K, 2006 | UNPHASED TDT P-value=0.239, global P-value=0.737, no SNP with nominal P-value<0.05 located in this gene | Non-significant |
Domschke K, 2005 | no polymorphism was significantly associated with ADHD | Non-significant |
Jiang S, 2001 | the results showed that ADHD was not in linkage with MAOB gene | Non-significant |
Lowe N, 2001 | there was no significant association with ADHD in this study | Non-significant |
Literature-origin SNPs (count: 4)
rs_ID | Location | Functional Annotation | No. of Studies (significant/non-significant/trend) |
---|---|---|---|
rs3027415 | ChrX:43614441(Fwd) | 1(1/0/0) | |
rs1799836 | ChrX:43627999(Fwd) | NMD_transcript_variant; intron_variant | 2(1/1/0) |
rs1040399 | ChrX:43625399(Fwd) | downstream_gene_variant | 1(1/0/0) |
rs3838196 | ChrX:43702604(Fwd) | downstream_gene_variant; feature_truncation; intron_variant; nc_transcript_variant | 1(0/1/0) |
LD-proxies (count: 39)
rs_ID | Location | Functional Annotation |
---|---|---|
rs3027449 | ChrX:43649217(Fwd) | intron_variant |
rs3027452 | ChrX:43657789(Fwd) | intron_variant; nc_transcript_variant |
rs5905512 | ChrX:43726394(Fwd) | intron_variant; nc_transcript_variant |
rs4824562 | ChrX:43703790(Fwd) | intron_variant; nc_transcript_variant; non_coding_exon_variant |
rs736944 | ChrX:43675035(Fwd) | intron_variant; nc_transcript_variant |
rs5952799 | ChrX:43704843(Fwd) | intron_variant; nc_transcript_variant |
rs3027441 | ChrX:43626868(Fwd) | NMD_transcript_variant; intron_variant; splice_region_variant |
rs5952671 | ChrX:43626968(Fwd) | NMD_transcript_variant; intron_variant |
rs2239449 | ChrX:43630201(Fwd) | intron_variant; upstream_gene_variant |
rs2283727 | ChrX:43632944(Fwd) | intron_variant; upstream_gene_variant |
rs3027435 | ChrX:43624239(Fwd) | downstream_gene_variant |
rs1040398 | ChrX:43625431(Fwd) | downstream_gene_variant |
rs3027439 | ChrX:43626136(Fwd) | 3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant |
rs2072745 | ChrX:43626329(Fwd) | 3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant |
rs5905449 | ChrX:43655653(Fwd) | downstream_gene_variant; intron_variant |
rs7067187 | ChrX:43684216(Fwd) | intron_variant; nc_transcript_variant |
rs2092041 | ChrX:43647641(Fwd) | intron_variant |
rs10521432 | ChrX:43633740(Fwd) | intron_variant |
rs2092042 | ChrX:43647663(Fwd) | intron_variant |
rs3027453 | ChrX:43657865(Fwd) | intron_variant; nc_transcript_variant |
rs3027450 | ChrX:43651195(Fwd) | intron_variant |
rs3027458 | ChrX:43661150(Fwd) | intron_variant; nc_transcript_variant |
rs3027461 | ChrX:43661708(Fwd) | intron_variant; nc_transcript_variant |
rs7888450 | ChrX:43634003(Fwd) | intron_variant |
rs1014876 | ChrX:43667348(Fwd) | intron_variant; nc_transcript_variant |
rs7890174 | ChrX:43638952(Fwd) | intron_variant |
rs3027456 | ChrX:43660135(Fwd) | intron_variant; nc_transcript_variant |
rs12394221 | ChrX:43669949(Fwd) | intron_variant; nc_transcript_variant |
rs17310637 | ChrX:43639979(Fwd) | intron_variant |
rs2283729 | ChrX:43678042(Fwd) | intron_variant; nc_transcript_variant |
rs2239450 | ChrX:43683127(Fwd) | intron_variant; nc_transcript_variant |
rs7892217 | ChrX:43640804(Fwd) | intron_variant |
rs3027440 | ChrX:43626481(Fwd) | 3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant |
rs3027438 | ChrX:43626085(Fwd) | 3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant |
rs6324 | ChrX:43626815(Fwd) | 3_prime_UTR_variant; NMD_transcript_variant; synonymous_variant |
rs7886240 | ChrX:43621768(Fwd) | downstream_gene_variant |
rs7884135 | ChrX:43621409(Fwd) | downstream_gene_variant |
rs12558036 | ChrX:43623280(Fwd) | downstream_gene_variant |
rs3027431 | ChrX:43623084(Fwd) | downstream_gene_variant |
Variant Name | Variant Type | Location in Gene | No. of Studies (significant/non-significant/trend) |
---|---|---|---|
MAOB_exon15_2276T>C | point mutation | exon 15 | 1 (1/0/0) |
MAOB_exon15_2327T>C | point mutation | exon 15 | 1 (1/0/0) |
MAOB_(GT)n | microsatellite | 1 (0/1/0) |
GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)
GO terms by database search (count: 19)
ID | Name | No. of Genes in ADHDgene | Brief Description |
---|---|---|---|
hsa00380 | Tryptophan metabolism | 12 | |
hsa01100 | Metabolic pathways | 237 | |
hsa00330 | Arginine and proline metabolism | 13 | |
hsa00260 | Glycine, serine and threonine metabolism | 6 | Serine is derived from 3-phospho-D-glycerate, an intermediat...... Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018]. More... |
hsa00360 | Phenylalanine metabolism | 8 | |
hsa00350 | Tyrosine metabolism | 15 | |
hsa00982 | Drug metabolism - cytochrome P450 | 29 | |
hsa00340 | Histidine metabolism | 12 |
Region: chrX:43625857..43741721 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014