ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED30
Previous Symbol	THRAP6
Symbol Alias	TRAP25
Approved Name	mediator complex subunit 30
Previous Name	thyroid hormone receptor associated protein 6
Location	8q24.11
Position	chr8:118532952-118552501, +
External Links	HGNC: 23032 Entrez Gene: 90390 Ensembl: ENSG00000164758 UCSC: uc003yoj.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[10198638]	80
GO:0042809	vitamin D receptor binding	Molecular Function	NAS[10235266]	11
GO:0030521	androgen receptor signaling pathway	Biological Process	IDA[12218053]	16
GO:0046966	thyroid hormone receptor binding	Molecular Function	IDA[10198638]	18
GO:0004872	receptor activity	Molecular Function	IDA[12218053]	36
GO:0005515	protein binding	Molecular Function		910
GO:0001104	RNA polymerase II transcription cofactor activity	Molecular Function	IDA[10198638]	16
GO:0003712	transcription cofactor activity	Molecular Function	IDA[12218053]	17
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IDA[12218053]	42
GO:0010467	gene expression	Biological Process		140
GO:0005634	nucleus	Cellular Component	IDA[10235267]	770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	NAS[10235266]	19
GO:0030518	intracellular steroid hormone receptor signaling pathway	Biological Process	IDA[11867769]	10
GO:0016592	mediator complex	Cellular Component	IDA[10198638]	17
GO:0019827	stem cell maintenance	Biological Process		12

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED30 (count: 38)

Gene Symbol	Pathway Count	Pathway List
MED1	16	positive regulation of transcription, DNA-dependent; vitamin D receptor binding; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; receptor activity; protein binding; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; mediator complex;
MED12	16	positive regulation of transcription, DNA-dependent; vitamin D receptor binding; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; receptor activity; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; mediator complex; stem cell maintenance;
MED14	16	positive regulation of transcription, DNA-dependent; vitamin D receptor binding; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; receptor activity; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; mediator complex; stem cell maintenance;
MED17	16	positive regulation of transcription, DNA-dependent; vitamin D receptor binding; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; receptor activity; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; mediator complex; stem cell maintenance;
MED24	16	positive regulation of transcription, DNA-dependent; vitamin D receptor binding; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; receptor activity; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; mediator complex; stem cell maintenance;
MED4	16	positive regulation of transcription, DNA-dependent; vitamin D receptor binding; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; receptor activity; protein binding; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; mediator complex;
MED13	15	positive regulation of transcription, DNA-dependent; vitamin D receptor binding; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; receptor activity; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; mediator complex;
THRAP3	14	positive regulation of transcription, DNA-dependent; vitamin D receptor binding; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; receptor activity; protein binding; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription initiation from RNA polymerase II promoter; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; mediator complex;
MED16	13	positive regulation of transcription, DNA-dependent; vitamin D receptor binding; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; receptor activity; transcription cofactor activity; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; intracellular steroid hormone receptor signaling pathway; mediator complex;
NCOA6	8	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; thyroid hormone receptor binding; protein binding; transcription initiation from RNA polymerase II promoter; nucleus; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity;
MED15	8	protein binding; RNA polymerase II transcription cofactor activity; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; mediator complex; stem cell maintenance;
SNW1	7	vitamin D receptor binding; nuclear hormone receptor binding; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
MED7	7	protein binding; RNA polymerase II transcription cofactor activity; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm; mediator complex; stem cell maintenance;
HMGA1	6	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; protein binding; nucleus; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity;
SMARCD3	6	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; protein binding; nucleus; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity;
NCOR1	6	thyroid hormone receptor binding; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
NRIP1	5	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; androgen receptor signaling pathway; protein binding; nucleus;
NSD1	5	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; thyroid hormone receptor binding; transcription cofactor activity; nucleus;
RAN	5	positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; protein binding; gene expression; nucleoplasm;
TP53BP1	5	positive regulation of transcription, DNA-dependent; protein binding; RNA polymerase II transcription cofactor activity; nucleus; nucleoplasm;
PPARGC1B	5	nuclear hormone receptor binding; RNA polymerase II transcription cofactor activity; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex;
PRPF6	5	nuclear hormone receptor binding; protein binding; gene expression; nucleus; nucleoplasm;
TRIP12	5	nuclear hormone receptor binding; thyroid hormone receptor binding; protein binding; nucleus; nucleoplasm;
ESRRA	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
MAML1	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
MED23	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm; mediator complex;
MEN1	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
NCOR2	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
NEDD4L	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
NR4A2	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
NR5A1	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
PGR	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
RBM14	5	protein binding; RNA polymerase II transcription cofactor activity; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex;
RBPJ	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
SMC1A	5	protein binding; gene expression; nucleus; nucleoplasm; stem cell maintenance;
TAF10	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
TAF13	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;
YAP1	5	protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm;

Genes shared at least 2 KEGG pathways with MED30 (count: 0)

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Region: chr8:118532952..118552501 View in gBrowse