ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TAF10
Previous Symbol	TAF2H, TAF2A
Symbol Alias	TAFII30
Approved Name	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
Previous Name	TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30kD
Location	11p15.5-p15.2
Position	chr11:6627526-6633898, -
External Links	HGNC: 11543 Entrez Gene: 6881 Ensembl: ENSG00000166337 UCSC: uc001mej.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_29	chr11:5582423-7488751 (NCBI Build 36.1 (hg18))	1859865	11p15.4	Loss	De novo

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0070063	RNA polymerase binding	Molecular Function	IDA[15099517]	3
GO:0016578	histone deubiquitination	Biological Process	IDA[18206972]	3
GO:0019899	enzyme binding	Molecular Function	IPI[16415881]	47
GO:0030331	estrogen receptor binding	Molecular Function	IDA[7923369]	10
GO:0030914	STAGA complex	Cellular Component	IDA[11564863]	3
GO:0033276	transcription factor TFTC complex	Cellular Component	IDA[10373431]	2
GO:0043966	histone H3 acetylation	Biological Process	IDA[9674425]	6
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA[15870280]	87
GO:0051260	protein homooligomerization	Biological Process	IDA[7923369]	34
GO:0005634	nucleus	Cellular Component	IDA[15099517]	770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0004402	histone acetyltransferase activity	Molecular Function	IDA[9674425]	9
GO:0005515	protein binding	Molecular Function	IPI[11438666,15870280]	910
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[9603525]	132
GO:0003713	transcription coactivator activity	Molecular Function	IDA[11564863]	52
GO:0000125	PCAF complex	Cellular Component	IDA[9674425]	2
GO:0010467	gene expression	Biological Process		140
GO:0016032	viral reproduction	Biological Process		57
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IC[7729427]; IDA[9603525]	42
GO:0006368	transcription elongation from RNA polymerase II promoter	Biological Process		10
GO:0006352	DNA-dependent transcription, initiation	Biological Process	IDA[9212049]	8
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	IC[7729427]	62
GO:0005669	transcription factor TFIID complex	Cellular Component	IDA[15099517]	3
GO:0005737	cytoplasm	Cellular Component	IDA[15870280]	690

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03022	Basal transcription factors	6

Genes shared at least 5 GO terms with TAF10 (count: 81)

Gene Symbol	Pathway Count	Pathway List
TAF13	11	nucleus; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; gene expression; viral reproduction; transcription initiation from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; DNA-dependent transcription, initiation; transcription from RNA polymerase II promoter; transcription factor TFIID complex;
TAF4B	11	nucleus; nucleoplasm; sequence-specific DNA binding transcription factor activity; gene expression; viral reproduction; transcription initiation from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; DNA-dependent transcription, initiation; transcription from RNA polymerase II promoter; transcription factor TFIID complex; cytoplasm;
SUPT3H	9	histone deubiquitination; STAGA complex; transcription factor TFTC complex; histone H3 acetylation; nucleus; histone acetyltransferase activity; transcription coactivator activity; DNA-dependent transcription, initiation; transcription from RNA polymerase II promoter;
NCOA6	8	enzyme binding; estrogen receptor binding; nucleus; nucleoplasm; protein binding; transcription coactivator activity; transcription initiation from RNA polymerase II promoter; DNA-dependent transcription, initiation;
PSMC3	8	perinuclear region of cytoplasm; nucleus; nucleoplasm; protein binding; transcription coactivator activity; gene expression; viral reproduction; cytoplasm;
NCOR1	8	nucleus; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; gene expression; transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; cytoplasm;
SSRP1	8	nucleus; nucleoplasm; protein binding; gene expression; viral reproduction; transcription elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; cytoplasm;
NR5A1	7	enzyme binding; nucleus; nucleoplasm; protein binding; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
PGR	7	enzyme binding; nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter; cytoplasm;
MED1	7	estrogen receptor binding; nucleus; nucleoplasm; protein binding; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
NCBP1	7	nucleus; nucleoplasm; protein binding; gene expression; viral reproduction; transcription elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter;
POLR2G	7	nucleus; nucleoplasm; gene expression; viral reproduction; transcription initiation from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter;
RBPJ	7	nucleus; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; gene expression; transcription initiation from RNA polymerase II promoter; cytoplasm;
YAP1	7	nucleus; nucleoplasm; protein binding; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter; cytoplasm;
GTF2H3	7	nucleoplasm; sequence-specific DNA binding transcription factor activity; gene expression; viral reproduction; transcription initiation from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter;
HINFP	6	enzyme binding; nucleus; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;
HMGA1	6	enzyme binding; nucleus; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; viral reproduction;
TAF6L	6	STAGA complex; histone H3 acetylation; histone acetyltransferase activity; protein binding; transcription coactivator activity; DNA-dependent transcription, initiation;
TADA2A	6	histone H3 acetylation; nucleus; histone acetyltransferase activity; sequence-specific DNA binding transcription factor activity; PCAF complex; transcription from RNA polymerase II promoter;
IRF9	6	nucleus; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; cytoplasm;
MAML1	6	nucleus; nucleoplasm; protein binding; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
MED16	6	nucleus; nucleoplasm; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter;
MED4	6	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter;
MEN1	6	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter; cytoplasm;
NEDD4L	6	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter; cytoplasm;
NR4A2	6	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter; cytoplasm;
SNW1	6	nucleus; nucleoplasm; protein binding; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
E2F5	6	nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; gene expression; transcription initiation from RNA polymerase II promoter; cytoplasm;
RAN	6	nucleoplasm; protein binding; transcription coactivator activity; gene expression; viral reproduction; cytoplasm;
TCEB1	6	nucleoplasm; protein binding; gene expression; viral reproduction; transcription elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter;
HOXA9	5	enzyme binding; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; cytoplasm;
KDM1A	5	enzyme binding; nucleus; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity;
RAD9A	5	enzyme binding; nucleus; nucleoplasm; protein binding; cytoplasm;
SNRPD3	5	enzyme binding; nucleoplasm; protein binding; gene expression; transcription from RNA polymerase II promoter;
U2AF2	5	enzyme binding; nucleoplasm; protein binding; gene expression; transcription from RNA polymerase II promoter;
MMS19	5	estrogen receptor binding; nucleus; protein binding; transcription coactivator activity; cytoplasm;
EHD3	5	perinuclear region of cytoplasm; protein homooligomerization; nucleus; protein binding; cytoplasm;
KAT5	5	perinuclear region of cytoplasm; nucleus; histone acetyltransferase activity; protein binding; transcription coactivator activity;
NRBP1	5	perinuclear region of cytoplasm; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
ARRB1	5	nucleus; histone acetyltransferase activity; protein binding; transcription from RNA polymerase II promoter; cytoplasm;
ATF6	5	nucleus; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;
CD2BP2	5	nucleus; nucleoplasm; protein binding; gene expression; cytoplasm;
CPSF7	5	nucleus; nucleoplasm; protein binding; gene expression; transcription from RNA polymerase II promoter;
DGCR8	5	nucleus; nucleoplasm; protein binding; gene expression; cytoplasm;
DHX9	5	nucleus; nucleoplasm; protein binding; gene expression; cytoplasm;
EFTUD2	5	nucleus; nucleoplasm; protein binding; gene expression; cytoplasm;
ESRRA	5	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
FUS	5	nucleus; nucleoplasm; protein binding; gene expression; cytoplasm;
GATA6	5	nucleus; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter;
HNRNPA2B1	5	nucleus; nucleoplasm; protein binding; gene expression; cytoplasm;
HNRNPH1	5	nucleus; nucleoplasm; protein binding; gene expression; cytoplasm;
HSF2	5	nucleus; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription from RNA polymerase II promoter; cytoplasm;
IRF7	5	nucleus; nucleoplasm; protein binding; transcription from RNA polymerase II promoter; cytoplasm;
LSM11	5	nucleus; nucleoplasm; protein binding; gene expression; transcription from RNA polymerase II promoter;
MAML2	5	nucleus; nucleoplasm; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
MED12	5	nucleus; nucleoplasm; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
MED13	5	nucleus; nucleoplasm; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
MED14	5	nucleus; nucleoplasm; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
MED15	5	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
MED17	5	nucleus; nucleoplasm; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
MED24	5	nucleus; nucleoplasm; histone acetyltransferase activity; gene expression; transcription initiation from RNA polymerase II promoter;
MED30	5	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
NCOR2	5	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
PRPF6	5	nucleus; nucleoplasm; protein binding; transcription coactivator activity; gene expression;
PTTG1	5	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; cytoplasm;
RCC1	5	nucleus; nucleoplasm; protein binding; viral reproduction; cytoplasm;
RELA	5	nucleus; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; cytoplasm;
RPS3	5	nucleus; protein binding; gene expression; viral reproduction; cytoplasm;
SMARCD3	5	nucleus; nucleoplasm; protein binding; transcription coactivator activity; cytoplasm;
SMC1A	5	nucleus; nucleoplasm; protein binding; gene expression; cytoplasm;
STRN3	5	nucleus; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; cytoplasm;
TFAP2A	5	nucleus; protein binding; transcription coactivator activity; transcription from RNA polymerase II promoter; cytoplasm;
U2AF1	5	nucleus; nucleoplasm; protein binding; gene expression; transcription from RNA polymerase II promoter;
XRCC5	5	nucleus; nucleoplasm; protein binding; viral reproduction; cytoplasm;
MED23	5	nucleoplasm; protein binding; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
MED7	5	nucleoplasm; protein binding; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
NR3C2	5	nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; gene expression; transcription initiation from RNA polymerase II promoter;
RORA	5	nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; gene expression; transcription initiation from RNA polymerase II promoter;
UBB	5	nucleoplasm; protein binding; gene expression; viral reproduction; transcription initiation from RNA polymerase II promoter;
UBC	5	nucleoplasm; protein binding; gene expression; viral reproduction; transcription initiation from RNA polymerase II promoter;
XPO1	5	nucleoplasm; protein binding; gene expression; viral reproduction; cytoplasm;

Genes shared at least 2 KEGG pathways with TAF10 (count: 0)

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Region: chr11:6627526..6633898 View in gBrowse