ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CUL5
Symbol Alias	VACM-1
Approved Name	cullin 5
Location	11q22.3
Position	chr11:107879408-107978503, +
External Links	HGNC: 2556 Entrez Gene: 8065 Ensembl: ENSG00000166266 UCSC: uc001pjv.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005262	calcium channel activity	Molecular Function	TAS[9581826]	40

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process		25
GO:0006970	response to osmotic stress	Biological Process		2
GO:0005829	cytosol	Cellular Component		447
GO:0005886	plasma membrane	Cellular Component		772
GO:0008285	negative regulation of cell proliferation	Biological Process	TAS[8681378]	59
GO:0016032	viral reproduction	Biological Process		57
GO:0007050	cell cycle arrest	Biological Process	TAS[8681378]	25
GO:0008283	cell proliferation	Biological Process	TAS[9037604]	60
GO:0031466	Cul5-RING ubiquitin ligase complex	Cellular Component		1
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IDA[17636018]	23
GO:0016567	protein ubiquitination	Biological Process		41
GO:0019048	virus-host interaction	Biological Process		54
GO:0097193	intrinsic apoptotic signaling pathway	Biological Process	TAS[9581826]	6
GO:0051480	cytosolic calcium ion homeostasis	Biological Process		6
GO:0070588	calcium ion transmembrane transport	Biological Process	TAS[9581826]	7
GO:0004872	receptor activity	Molecular Function	TAS[9581826]	36
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component		770
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	TAS[8681378]	26

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

Genes shared at least 5 GO terms with CUL5 (count: 28)

Gene Symbol	Pathway Count	Pathway List
APC	6	cytosol; plasma membrane; negative regulation of cell proliferation; cell cycle arrest; protein binding; nucleus;
ARRB1	6	cytosol; plasma membrane; ubiquitin protein ligase binding; protein ubiquitination; protein binding; nucleus;
ARRB2	6	cytosol; plasma membrane; ubiquitin protein ligase binding; protein ubiquitination; protein binding; nucleus;
HMGA1	6	cytosol; negative regulation of cell proliferation; viral reproduction; virus-host interaction; protein binding; nucleus;
PDE2A	6	cytosol; plasma membrane; calcium ion transmembrane transport; calcium channel activity; protein binding; nucleus;
PSMC3	6	cytosol; viral reproduction; virus-host interaction; protein binding; nucleus; G1/S transition of mitotic cell cycle;
PARK2	5	ubiquitin-dependent protein catabolic process; cytosol; ubiquitin protein ligase binding; protein binding; nucleus;
RNF40	5	ubiquitin-dependent protein catabolic process; plasma membrane; ubiquitin protein ligase binding; protein binding; nucleus;
TCEB1	5	ubiquitin-dependent protein catabolic process; cytosol; viral reproduction; virus-host interaction; protein binding;
UBE3A	5	ubiquitin-dependent protein catabolic process; cytosol; virus-host interaction; protein binding; nucleus;
CBL	5	cytosol; plasma membrane; protein ubiquitination; protein binding; nucleus;
DAXX	5	cytosol; ubiquitin protein ligase binding; virus-host interaction; protein binding; nucleus;
GSK3B	5	cytosol; plasma membrane; ubiquitin protein ligase binding; protein binding; nucleus;
HSPA8	5	cytosol; plasma membrane; virus-host interaction; protein binding; nucleus;
ILK	5	cytosol; plasma membrane; cell cycle arrest; cell proliferation; protein binding;
MALT1	5	cytosol; plasma membrane; protein ubiquitination; protein binding; nucleus;
MEN1	5	cytosol; negative regulation of cell proliferation; cell cycle arrest; protein binding; nucleus;
NEDD4L	5	cytosol; protein ubiquitination; virus-host interaction; protein binding; nucleus;
PLK1	5	cytosol; cell proliferation; protein ubiquitination; protein binding; nucleus;
PRKD1	5	cytosol; plasma membrane; cell proliferation; protein binding; nucleus;
PSMB7	5	cytosol; viral reproduction; virus-host interaction; protein binding; G1/S transition of mitotic cell cycle;
RELA	5	cytosol; ubiquitin protein ligase binding; virus-host interaction; protein binding; nucleus;
SART1	5	cytosol; cell cycle arrest; intrinsic apoptotic signaling pathway; protein binding; nucleus;
SYK	5	cytosol; plasma membrane; cell proliferation; virus-host interaction; protein binding;
UBB	5	cytosol; plasma membrane; viral reproduction; protein binding; G1/S transition of mitotic cell cycle;
UBC	5	cytosol; plasma membrane; viral reproduction; protein binding; G1/S transition of mitotic cell cycle;
WWP1	5	cytosol; plasma membrane; protein ubiquitination; protein binding; nucleus;
XRCC5	5	viral reproduction; cell proliferation; ubiquitin protein ligase binding; protein binding; nucleus;

Genes shared at least 2 KEGG pathways with CUL5 (count: 0)

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Region: chr11:107879408..107978503 View in gBrowse