ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TCEB1
Symbol Alias	SIII
Approved Name	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
Previous Name	transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C)
Location	8q13.3
Position	chr8:74857354-74884522, -
External Links	HGNC: 11617 Entrez Gene: 6921 Ensembl: ENSG00000154582 UCSC: uc003xzx.1
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Neale BM, 2010 (a)	1 SNPs of top 50 hits located within the gene	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs16938747	Chr8:74879087(Fwd)	intron_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005829	cytosol	Cellular Component		447
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005515	protein binding	Molecular Function		910
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS[7660129]	42
GO:0006366	transcription from RNA polymerase II promoter	Biological Process		62
GO:0006368	transcription elongation from RNA polymerase II promoter	Biological Process		10
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process		25
GO:0010467	gene expression	Biological Process		140
GO:0016032	viral reproduction	Biological Process		57
GO:0019048	virus-host interaction	Biological Process		54
GO:0030891	VCB complex	Cellular Component		1
GO:0032403	protein complex binding	Molecular Function		27
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	Biological Process		2
GO:0033554	cellular response to stress	Biological Process		12
GO:0050434	positive regulation of viral transcription	Biological Process		6
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	Biological Process		5
GO:0071456	cellular response to hypoxia	Biological Process		12

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05211	Renal cell carcinoma	13	Renal cell cancer (RCC) accounts for ~3% of human malignanci...... Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal cancer accounts for 1-4% of cases. RCC is not a single disease, it has several morphological subtypes. Conventional RCC (clear cell RCC) accounts for ~80% of cases, followed by papillary RCC (10-15%), chromophobe RCC (5%), and collecting duct RCC (<1%). Genes potentially involved in sporadic neoplasms of each particular type are VHL, MET, BHD, and FH respectively. In the absence of VHL, hypoxia-inducible factor alpha (HIF-alpha) accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. Activated MET mediates a number of biological effects including motility, invasion of extracellular matrix, cellular transformation, prevention of apoptosis and metastasis formation. Loss of functional FH leads to accumulation of fumarate in the cell, triggering inhibition of HPH and preventing targeted pVHL-mediated degradation of HIF-alpha. BHD mutations cause the Birt-Hogg-Dube syndrome and its associated chromophobe, hybrid oncocytic, and conventional (clear cell) RCC. More...
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with TCEB1 (count: 28)

Gene Symbol	Pathway Count	Pathway List
NCBP1	8	cytosol; nucleoplasm; protein binding; transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; gene expression; viral reproduction; positive regulation of viral transcription;
UBB	8	cytosol; nucleoplasm; protein binding; gene expression; viral reproduction; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia;
UBC	8	cytosol; nucleoplasm; protein binding; gene expression; viral reproduction; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia;
SSRP1	7	nucleoplasm; protein binding; transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; gene expression; viral reproduction; positive regulation of viral transcription;
EGLN3	6	cytosol; nucleoplasm; protein binding; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia;
PSMB7	6	cytosol; nucleoplasm; protein binding; gene expression; viral reproduction; virus-host interaction;
PSMC3	6	cytosol; nucleoplasm; protein binding; gene expression; viral reproduction; virus-host interaction;
RAN	6	cytosol; nucleoplasm; protein binding; gene expression; viral reproduction; virus-host interaction;
XPO1	6	cytosol; nucleoplasm; protein binding; gene expression; viral reproduction; virus-host interaction;
GTF2H3	6	nucleoplasm; transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; gene expression; viral reproduction; positive regulation of viral transcription;
POLR2G	6	nucleoplasm; transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; gene expression; viral reproduction; positive regulation of viral transcription;
TAF10	6	nucleoplasm; protein binding; transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; gene expression; viral reproduction;
TAF13	6	nucleoplasm; protein binding; transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; gene expression; viral reproduction;
BANF1	5	cytosol; nucleoplasm; protein binding; viral reproduction; virus-host interaction;
CUL5	5	cytosol; protein binding; ubiquitin-dependent protein catabolic process; viral reproduction; virus-host interaction;
HMGA1	5	cytosol; nucleoplasm; protein binding; viral reproduction; virus-host interaction;
MAPK3	5	cytosol; nucleoplasm; protein binding; gene expression; virus-host interaction;
NEDD4L	5	cytosol; nucleoplasm; protein binding; gene expression; virus-host interaction;
NXF1	5	cytosol; nucleoplasm; protein binding; gene expression; virus-host interaction;
PSMD5	5	cytosol; nucleoplasm; protein binding; gene expression; viral reproduction;
PSMD7	5	cytosol; nucleoplasm; protein binding; gene expression; viral reproduction;
RELA	5	cytosol; nucleoplasm; protein binding; virus-host interaction; protein complex binding;
SNRPB	5	cytosol; nucleoplasm; protein binding; transcription from RNA polymerase II promoter; gene expression;
SNRPD3	5	cytosol; nucleoplasm; protein binding; transcription from RNA polymerase II promoter; gene expression;
SNRPG	5	cytosol; nucleoplasm; protein binding; transcription from RNA polymerase II promoter; gene expression;
SNW1	5	nucleoplasm; protein binding; regulation of transcription from RNA polymerase II promoter; gene expression; virus-host interaction;
TAF4B	5	nucleoplasm; transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; gene expression; viral reproduction;
VEGFA	5	protein binding; regulation of transcription from RNA polymerase II promoter; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia;

Genes shared at least 2 KEGG pathways with TCEB1 (count: 13)

Gene Symbol	Pathway Count	Pathway List
CRKL	2	Renal cell carcinoma; Pathways in cancer;
EGLN3	2	Renal cell carcinoma; Pathways in cancer;
ETS1	2	Renal cell carcinoma; Pathways in cancer;
MAPK1	2	Renal cell carcinoma; Pathways in cancer;
MAPK3	2	Renal cell carcinoma; Pathways in cancer;
PIK3CG	2	Renal cell carcinoma; Pathways in cancer;
PIK3R1	2	Renal cell carcinoma; Pathways in cancer;
VEGFA	2	Renal cell carcinoma; Pathways in cancer;
VEGFB	2	Renal cell carcinoma; Pathways in cancer;
BIRC2	2	Ubiquitin mediated proteolysis; Pathways in cancer;
BIRC3	2	Ubiquitin mediated proteolysis; Pathways in cancer;
CBL	2	Ubiquitin mediated proteolysis; Pathways in cancer;
SKP2	2	Ubiquitin mediated proteolysis; Pathways in cancer;

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Region: chr8:74857354..74884522 View in gBrowse