ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MMP3
Previous Symbol	STMY1, STMY
Approved Name	matrix metallopeptidase 3 (stromelysin 1, progelatinase)
Previous Name	matrix metalloproteinase 3 (stromelysin 1, progelatinase)
Location	11q22.3
Position	chr11:102706528-102714534, -
External Links	HGNC: 7173 Entrez Gene: 4314 Ensembl: ENSG00000149968 UCSC: uc001phj.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030334	regulation of cell migration	Biological Process		10
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0043231	intracellular membrane-bounded organelle	Cellular Component		62
GO:0030574	collagen catabolic process	Biological Process		10
GO:0071230	cellular response to amino acid stimulus	Biological Process		5
GO:0004222	metalloendopeptidase activity	Molecular Function		33
GO:0005509	calcium ion binding	Molecular Function		124
GO:0005576	extracellular region	Cellular Component		240
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0005615	extracellular space	Cellular Component	TAS[3360803]	126
GO:0006508	proteolysis	Biological Process		102
GO:0008270	zinc ion binding	Molecular Function		323
GO:0022617	extracellular matrix disassembly	Biological Process		14

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05323	Rheumatoid arthritis	17	Rheumatoid arthritis (RA) is a chronic autoimmune joint dise...... Rheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune system elevates pro-inflammatory cytokines and chemokines levels, which can promote synovial angiogenesis and leukocyte infiltration. The synovium forms a hyperplastic pannus with infiltrated macrophage-like and fibroblast-like synoviocytes and invades joints by secreting proteinases and inducing osteoclast differentiation. More...

Genes shared at least 5 GO terms with MMP3 (count: 17)

Gene Symbol	Pathway Count	Pathway List
MMP10	11	regulation of cell migration; extracellular matrix organization; collagen catabolic process; metalloendopeptidase activity; calcium ion binding; extracellular region; proteinaceous extracellular matrix; extracellular space; proteolysis; zinc ion binding; extracellular matrix disassembly;
MMP13	10	extracellular matrix organization; collagen catabolic process; metalloendopeptidase activity; calcium ion binding; extracellular region; proteinaceous extracellular matrix; extracellular space; proteolysis; zinc ion binding; extracellular matrix disassembly;
MMP8	10	extracellular matrix organization; collagen catabolic process; metalloendopeptidase activity; calcium ion binding; extracellular region; proteinaceous extracellular matrix; extracellular space; proteolysis; zinc ion binding; extracellular matrix disassembly;
MMP1	9	extracellular matrix organization; collagen catabolic process; metalloendopeptidase activity; calcium ion binding; extracellular region; proteinaceous extracellular matrix; proteolysis; zinc ion binding; extracellular matrix disassembly;
MMP11	9	extracellular matrix organization; collagen catabolic process; metalloendopeptidase activity; calcium ion binding; extracellular region; proteinaceous extracellular matrix; proteolysis; zinc ion binding; extracellular matrix disassembly;
MMP7	9	extracellular matrix organization; collagen catabolic process; metalloendopeptidase activity; extracellular region; proteinaceous extracellular matrix; extracellular space; proteolysis; zinc ion binding; extracellular matrix disassembly;
MMP16	8	extracellular matrix organization; collagen catabolic process; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis; zinc ion binding; extracellular matrix disassembly;
ADAMTS2	7	extracellular matrix organization; collagen catabolic process; metalloendopeptidase activity; extracellular region; proteinaceous extracellular matrix; proteolysis; zinc ion binding;
TLL1	6	extracellular matrix organization; metalloendopeptidase activity; calcium ion binding; extracellular region; proteolysis; zinc ion binding;
MMP27	6	collagen catabolic process; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis; zinc ion binding;
MMP20	6	metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; extracellular space; proteolysis; zinc ion binding;
CTRB1	5	extracellular matrix organization; extracellular region; extracellular space; proteolysis; extracellular matrix disassembly;
CTRB2	5	extracellular matrix organization; extracellular region; extracellular space; proteolysis; extracellular matrix disassembly;
CTSG	5	extracellular matrix organization; extracellular region; extracellular space; proteolysis; extracellular matrix disassembly;
MMP12	5	metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis; zinc ion binding;
MMP24	5	metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis; zinc ion binding;
TLL2	5	metalloendopeptidase activity; calcium ion binding; extracellular region; proteolysis; zinc ion binding;

Genes shared at least 2 KEGG pathways with MMP3 (count: 0)

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Region: chr11:102706528..102714534 View in gBrowse