ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MMP1
Previous Symbol	CLG
Approved Name	matrix metallopeptidase 1 (interstitial collagenase)
Previous Name	matrix metalloproteinase 1 (interstitial collagenase)
Location	11q21-q22
Position	chr11:102660641-102668966, -
External Links	HGNC: 7155 Entrez Gene: 4312 Ensembl: ENSG00000196611 UCSC: uc001phi.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005509	calcium ion binding	Molecular Function		124
GO:0004222	metalloendopeptidase activity	Molecular Function	IDA[9920899]	33
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0005576	extracellular region	Cellular Component		240
GO:0022617	extracellular matrix disassembly	Biological Process		14
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0030574	collagen catabolic process	Biological Process		10
GO:0050900	leukocyte migration	Biological Process		13
GO:0006508	proteolysis	Biological Process		102
GO:0007596	blood coagulation	Biological Process		83
GO:0008270	zinc ion binding	Molecular Function		323
GO:0019048	virus-host interaction	Biological Process		54

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05219	Bladder cancer	7	The urothelium covers the luminal surface of almost the enti...... The urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carcinoma are bladder carcinomas, and urothelial carcinomas of the renal pelvis and ureter account for only approximately 7% of the total. Urothelial tumours arise and evolve through divergent phenotypic pathways. Some tumours progress from urothelial hyperplasia to low-grade non-invasive superficial papillary tumours. More aggressive variants arise either from flat, high-grade carcinoma in situ (CIS) and progress to invasive tumours, or they arise de novo as invasive tumours. Low-grade papillary tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. In contrast, CIS and invasive tumors frequently show alterations in the TP53 and RB genes and pathways. Invasion and metastases are promoted by several factors that alter the tumour microenvironment, including the aberrant expression of E-cadherins (E-cad), matrix metalloproteinases (MMPs), angiogenic factors such as vascular endothelial growth factor (VEGF). More...
hsa05323	Rheumatoid arthritis	17	Rheumatoid arthritis (RA) is a chronic autoimmune joint dise...... Rheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune system elevates pro-inflammatory cytokines and chemokines levels, which can promote synovial angiogenesis and leukocyte infiltration. The synovium forms a hyperplastic pannus with infiltrated macrophage-like and fibroblast-like synoviocytes and invades joints by secreting proteinases and inducing osteoclast differentiation. More...
hsa03320	PPAR signaling pathway	12	Peroxisome proliferator-activated receptors (PPARs) are nucl...... Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with MMP1 (count: 14)

Gene Symbol	Pathway Count	Pathway List
MMP10	9	calcium ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; extracellular matrix disassembly; extracellular matrix organization; collagen catabolic process; proteolysis; zinc ion binding;
MMP11	9	calcium ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; extracellular matrix disassembly; extracellular matrix organization; collagen catabolic process; proteolysis; zinc ion binding;
MMP13	9	calcium ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; extracellular matrix disassembly; extracellular matrix organization; collagen catabolic process; proteolysis; zinc ion binding;
MMP3	9	calcium ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; extracellular matrix disassembly; extracellular matrix organization; collagen catabolic process; proteolysis; zinc ion binding;
MMP8	9	calcium ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; extracellular matrix disassembly; extracellular matrix organization; collagen catabolic process; proteolysis; zinc ion binding;
MMP16	8	calcium ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular matrix disassembly; extracellular matrix organization; collagen catabolic process; proteolysis; zinc ion binding;
MMP7	8	metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; extracellular matrix disassembly; extracellular matrix organization; collagen catabolic process; proteolysis; zinc ion binding;
ADAMTS2	7	metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; extracellular matrix organization; collagen catabolic process; proteolysis; zinc ion binding;
MMP27	6	calcium ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; collagen catabolic process; proteolysis; zinc ion binding;
TLL1	6	calcium ion binding; metalloendopeptidase activity; extracellular region; extracellular matrix organization; proteolysis; zinc ion binding;
MMP12	5	calcium ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding;
MMP20	5	calcium ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding;
MMP24	5	calcium ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding;
TLL2	5	calcium ion binding; metalloendopeptidase activity; extracellular region; proteolysis; zinc ion binding;

Genes shared at least 2 KEGG pathways with MMP1 (count: 7)

Gene Symbol	Pathway Count	Pathway List
VEGFA	3	Bladder cancer; Rheumatoid arthritis; Pathways in cancer;
VEGFB	3	Bladder cancer; Rheumatoid arthritis; Pathways in cancer;
CCND1	2	Bladder cancer; Pathways in cancer;
ERBB2	2	Bladder cancer; Pathways in cancer;
MAPK1	2	Bladder cancer; Pathways in cancer;
MAPK3	2	Bladder cancer; Pathways in cancer;
IL6	2	Rheumatoid arthritis; Pathways in cancer;

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Region: chr11:102660641..102668966 View in gBrowse