ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MMP7
Previous Symbol	MPSL1
Symbol Alias	PUMP-1
Approved Name	matrix metallopeptidase 7 (matrilysin, uterine)
Previous Name	matrix metalloproteinase 7 (matrilysin, uterine)
Location	11q21-q22
Position	chr11:102391239-102401484, -
External Links	HGNC: 7174 Entrez Gene: 4316 Ensembl: ENSG00000137673 UCSC: uc001phb.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2509689	Chr11:102368719(Fwd)	intron_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0002779	antibacterial peptide secretion	Biological Process		1
GO:0005576	extracellular region	Cellular Component		240
GO:0004222	metalloendopeptidase activity	Molecular Function		33
GO:0005615	extracellular space	Cellular Component	TAS[1497627]	126
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0008270	zinc ion binding	Molecular Function		323
GO:0006508	proteolysis	Biological Process		102
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0022617	extracellular matrix disassembly	Biological Process		14
GO:0042127	regulation of cell proliferation	Biological Process		20
GO:0030574	collagen catabolic process	Biological Process		10
GO:0050830	defense response to Gram-positive bacterium	Biological Process		6
GO:0042493	response to drug	Biological Process		68
GO:0050829	defense response to Gram-negative bacterium	Biological Process		7

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04310	Wnt signaling pathway	22	Wnt proteins are secreted morphogens that are required for b...... Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. More...

Genes shared at least 5 GO terms with MMP7 (count: 15)

Gene Symbol	Pathway Count	Pathway List
MMP10	9	extracellular region; metalloendopeptidase activity; extracellular space; proteinaceous extracellular matrix; zinc ion binding; proteolysis; extracellular matrix organization; extracellular matrix disassembly; collagen catabolic process;
MMP13	9	extracellular region; metalloendopeptidase activity; extracellular space; proteinaceous extracellular matrix; zinc ion binding; proteolysis; extracellular matrix organization; extracellular matrix disassembly; collagen catabolic process;
MMP3	9	extracellular region; metalloendopeptidase activity; extracellular space; proteinaceous extracellular matrix; zinc ion binding; proteolysis; extracellular matrix organization; extracellular matrix disassembly; collagen catabolic process;
MMP8	9	extracellular region; metalloendopeptidase activity; extracellular space; proteinaceous extracellular matrix; zinc ion binding; proteolysis; extracellular matrix organization; extracellular matrix disassembly; collagen catabolic process;
MMP1	8	extracellular region; metalloendopeptidase activity; proteinaceous extracellular matrix; zinc ion binding; proteolysis; extracellular matrix organization; extracellular matrix disassembly; collagen catabolic process;
MMP11	8	extracellular region; metalloendopeptidase activity; proteinaceous extracellular matrix; zinc ion binding; proteolysis; extracellular matrix organization; extracellular matrix disassembly; collagen catabolic process;
ADAMTS2	7	extracellular region; metalloendopeptidase activity; proteinaceous extracellular matrix; zinc ion binding; proteolysis; extracellular matrix organization; collagen catabolic process;
MMP16	7	metalloendopeptidase activity; proteinaceous extracellular matrix; zinc ion binding; proteolysis; extracellular matrix organization; extracellular matrix disassembly; collagen catabolic process;
CTRB1	5	extracellular region; extracellular space; proteolysis; extracellular matrix organization; extracellular matrix disassembly;
CTRB2	5	extracellular region; extracellular space; proteolysis; extracellular matrix organization; extracellular matrix disassembly;
CTSG	5	extracellular region; extracellular space; proteolysis; extracellular matrix organization; extracellular matrix disassembly;
IL6	5	extracellular region; extracellular space; defense response to Gram-positive bacterium; response to drug; defense response to Gram-negative bacterium;
TLL1	5	extracellular region; metalloendopeptidase activity; zinc ion binding; proteolysis; extracellular matrix organization;
MMP20	5	metalloendopeptidase activity; extracellular space; proteinaceous extracellular matrix; zinc ion binding; proteolysis;
MMP27	5	metalloendopeptidase activity; proteinaceous extracellular matrix; zinc ion binding; proteolysis; collagen catabolic process;

Genes shared at least 2 KEGG pathways with MMP7 (count: 0)

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Region: chr11:102391239..102401484 View in gBrowse