ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PSMD5
Symbol Alias	S5B, KIAA0072
Approved Name	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
Location	9q34.11
Position	chr9:123577774-123605206, -
External Links	HGNC: 9563 Entrez Gene: 5711 Ensembl: ENSG00000095261 UCSC: uc004bko.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process		14
GO:0034641	cellular nitrogen compound metabolic process	Biological Process		30
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0022624	proteasome accessory complex	Cellular Component		2
GO:0044183	protein binding involved in protein folding	Molecular Function		1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Biological Process		14
GO:0042981	regulation of apoptotic process	Biological Process		32
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0070682	proteasome regulatory particle assembly	Biological Process	TAS[19490896]	1
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		10
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0000216	M/G1 transition of mitotic cell cycle	Biological Process		13
GO:0000209	protein polyubiquitination	Biological Process		23
GO:0000502	proteasome complex	Cellular Component	TAS[8811196]	14
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Biological Process		14
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process		17
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005515	protein binding	Molecular Function	IPI[19490896]	910
GO:0006521	regulation of cellular amino acid metabolic process	Biological Process		9
GO:0005829	cytosol	Cellular Component		447
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Biological Process		11
GO:0006915	apoptotic process	Biological Process		111
GO:0010467	gene expression	Biological Process		140
GO:0008540	proteasome regulatory particle, base subcomplex	Cellular Component	IDA[19412159]	1
GO:0016070	RNA metabolic process	Biological Process		46
GO:0016032	viral reproduction	Biological Process		57
GO:0000075	cell cycle checkpoint	Biological Process		21
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process		26
GO:0000084	S phase of mitotic cell cycle	Biological Process		20

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PSMD5 (count: 55)

Gene Symbol	Pathway Count	Pathway List
PSMC3	28	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular nitrogen compound metabolic process; mRNA metabolic process; proteasome accessory complex; small molecule metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; regulation of apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; proteasome complex; mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; nucleoplasm; protein binding; regulation of cellular amino acid metabolic process; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; gene expression; RNA metabolic process; viral reproduction; cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
PSMB7	27	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular nitrogen compound metabolic process; mRNA metabolic process; small molecule metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; regulation of apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; proteasome complex; mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; nucleoplasm; protein binding; regulation of cellular amino acid metabolic process; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; gene expression; RNA metabolic process; viral reproduction; cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
PSMD7	27	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular nitrogen compound metabolic process; mRNA metabolic process; small molecule metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; regulation of apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; proteasome complex; mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; nucleoplasm; protein binding; regulation of cellular amino acid metabolic process; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; gene expression; RNA metabolic process; viral reproduction; cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
PSME1	26	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular nitrogen compound metabolic process; mRNA metabolic process; small molecule metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; regulation of apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; proteasome complex; mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; nucleoplasm; regulation of cellular amino acid metabolic process; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; gene expression; RNA metabolic process; viral reproduction; cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
PSME2	26	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular nitrogen compound metabolic process; mRNA metabolic process; small molecule metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; regulation of apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; proteasome complex; mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; nucleoplasm; regulation of cellular amino acid metabolic process; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; gene expression; RNA metabolic process; viral reproduction; cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
UBB	23	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; regulation of apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; nucleoplasm; protein binding; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; gene expression; RNA metabolic process; viral reproduction; cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
UBC	23	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; regulation of apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; nucleoplasm; protein binding; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; gene expression; RNA metabolic process; viral reproduction; cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
PSMA8	22	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular nitrogen compound metabolic process; mRNA metabolic process; small molecule metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; regulation of apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; regulation of cellular amino acid metabolic process; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; gene expression; RNA metabolic process; viral reproduction; cell cycle checkpoint; S phase of mitotic cell cycle;
CDC26	9	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; nucleoplasm; protein binding; cytosol; cell cycle checkpoint;
ANAPC4	8	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; nucleoplasm; cytosol; cell cycle checkpoint;
SKP2	8	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; mitotic cell cycle; nucleoplasm; protein binding; cytosol; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
XPO1	8	mRNA metabolic process; mitotic cell cycle; nucleoplasm; protein binding; cytosol; gene expression; RNA metabolic process; viral reproduction;
PLK1	7	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; nucleoplasm; protein binding; cytosol;
NCBP1	7	mRNA metabolic process; nucleoplasm; protein binding; cytosol; gene expression; RNA metabolic process; viral reproduction;
CDC45	7	M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleoplasm; protein binding; cell cycle checkpoint; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
CDT1	7	M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleoplasm; protein binding; cytosol; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
RPL13	6	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process; viral reproduction;
RPL14	6	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process; viral reproduction;
RPS3	6	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process; viral reproduction;
RPS9	6	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process; viral reproduction;
RRM2	6	small molecule metabolic process; mitotic cell cycle; nucleoplasm; protein binding; cytosol; G1/S transition of mitotic cell cycle;
CCND1	6	mitotic cell cycle; nucleoplasm; protein binding; cytosol; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
CNOT6	5	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process;
DCPS	5	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process;
DDX6	5	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process;
FAU	5	mRNA metabolic process; cytosol; gene expression; RNA metabolic process; viral reproduction;
HSPA8	5	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process;
LSM4	5	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process;
PATL1	5	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process;
RPL12	5	mRNA metabolic process; cytosol; gene expression; RNA metabolic process; viral reproduction;
RPL35	5	mRNA metabolic process; cytosol; gene expression; RNA metabolic process; viral reproduction;
RPL37	5	mRNA metabolic process; cytosol; gene expression; RNA metabolic process; viral reproduction;
RPL37A	5	mRNA metabolic process; cytosol; gene expression; RNA metabolic process; viral reproduction;
RPL38	5	mRNA metabolic process; cytosol; gene expression; RNA metabolic process; viral reproduction;
RPS12	5	mRNA metabolic process; cytosol; gene expression; RNA metabolic process; viral reproduction;
RPS15A	5	mRNA metabolic process; cytosol; gene expression; RNA metabolic process; viral reproduction;
RPS25	5	mRNA metabolic process; cytosol; gene expression; RNA metabolic process; viral reproduction;
RQCD1	5	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process;
SMG1	5	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process;
SMG7	5	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process;
DHFRP1	5	small molecule metabolic process; mitotic cell cycle; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle;
NCF2	5	antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; protein binding; cytosol;
SEC61B	5	antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; protein binding; gene expression;
POLA2	5	M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleoplasm; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
POLE	5	M/G1 transition of mitotic cell cycle; mitotic cell cycle; nucleoplasm; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
SMC1A	5	mitotic cell cycle; nucleoplasm; protein binding; gene expression; cell cycle checkpoint;
MAPK3	5	nucleoplasm; protein binding; cytosol; apoptotic process; gene expression;
RAN	5	nucleoplasm; protein binding; cytosol; gene expression; viral reproduction;
RFWD2	5	nucleoplasm; protein binding; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; cell cycle checkpoint;
SNRPB	5	nucleoplasm; protein binding; cytosol; gene expression; RNA metabolic process;
SNRPD1	5	nucleoplasm; protein binding; cytosol; gene expression; RNA metabolic process;
SNRPD2	5	nucleoplasm; protein binding; cytosol; gene expression; RNA metabolic process;
SNRPD3	5	nucleoplasm; protein binding; cytosol; gene expression; RNA metabolic process;
SNRPG	5	nucleoplasm; protein binding; cytosol; gene expression; RNA metabolic process;
TCEB1	5	nucleoplasm; protein binding; cytosol; gene expression; viral reproduction;

Genes shared at least 2 KEGG pathways with PSMD5 (count: 0)

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Region: chr9:123577774..123605206 View in gBrowse