ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TAOK2
Symbol Alias	TAO1, KIAA0881, PSK, PSK1, TAO2, MAP3K17
Approved Name	TAO kinase 2
Location	16p11.2
Position	chr16:29985222-30003582, +
External Links	HGNC: 16835 Entrez Gene: 9344 Ensembl: ENSG00000149930 UCSC: uc002dva.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 4)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_16	chr16:29563594-30367556 (NCBI Build 36.1 (hg18))	803963	16p11.2	Loss
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain
CNV_Jarick[2012]_35	chr16:29554843-30085308 (NCBI36 / hg18)	530466	16p11.2	del

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 25)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000186	activation of MAPKK activity	Biological Process	IDA[10660600]	9
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA[11279118]	61
GO:0001558	regulation of cell growth	Biological Process	NAS[10660600]	11
GO:0030425	dendrite	Cellular Component		46
GO:0030659	cytoplasmic vesicle membrane	Cellular Component		18
GO:0016477	cell migration	Biological Process	NAS[10660600]	24
GO:0030036	actin cytoskeleton organization	Biological Process	IDA[10660600]	21
GO:0016021	integral to membrane	Cellular Component		845
GO:0016023	cytoplasmic membrane-bounded vesicle	Cellular Component	IDA[10660600]	16
GO:0006974	response to DNA damage stimulus	Biological Process	IDA[17396146]	37
GO:0008360	regulation of cell shape	Biological Process	IDA[10660600]	20
GO:0006915	apoptotic process	Biological Process	NAS[10660600]	111
GO:0006950	response to stress	Biological Process	IDA[10660600]	30
GO:0005856	cytoskeleton	Cellular Component		54
GO:0006612	protein targeting to membrane	Biological Process	NAS[10660600]	2
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component		690
GO:0005524	ATP binding	Molecular Function		228
GO:0005634	nucleus	Cellular Component		770
GO:0051403	stress-activated MAPK cascade	Biological Process	IDA[11279118]	10
GO:0048041	focal adhesion assembly	Biological Process	IDA[10660600]	4
GO:0046330	positive regulation of JNK cascade	Biological Process	IDA[10660600]	12
GO:0032874	positive regulation of stress-activated MAPK cascade	Biological Process	IMP[17396146]	2
GO:0031572	G2/M transition DNA damage checkpoint	Biological Process	IMP[17396146]	7
GO:0031434	mitogen-activated protein kinase kinase binding	Molecular Function	IPI[11279118]	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with TAOK2 (count: 20)

Gene Symbol	Pathway Count	Pathway List
MAPK1	11	activation of MAPKK activity; protein serine/threonine kinase activity; response to DNA damage stimulus; apoptotic process; response to stress; cytoskeleton; nucleolus; cytoplasm; ATP binding; nucleus; stress-activated MAPK cascade;
MAPK3	8	activation of MAPKK activity; response to DNA damage stimulus; apoptotic process; cytoskeleton; nucleolus; ATP binding; nucleus; stress-activated MAPK cascade;
SGK1	7	protein serine/threonine kinase activity; regulation of cell growth; response to DNA damage stimulus; apoptotic process; response to stress; ATP binding; nucleus;
GSK3B	6	protein serine/threonine kinase activity; cell migration; nucleolus; cytoplasm; ATP binding; nucleus;
NEK6	6	protein serine/threonine kinase activity; apoptotic process; cytoplasm; ATP binding; nucleus; G2/M transition DNA damage checkpoint;
ATM	5	protein serine/threonine kinase activity; cytoplasmic membrane-bounded vesicle; response to DNA damage stimulus; ATP binding; G2/M transition DNA damage checkpoint;
CHEK1	5	protein serine/threonine kinase activity; response to DNA damage stimulus; ATP binding; nucleus; G2/M transition DNA damage checkpoint;
ERN2	5	protein serine/threonine kinase activity; integral to membrane; apoptotic process; response to stress; ATP binding;
MAP3K11	5	protein serine/threonine kinase activity; cytoplasm; ATP binding; positive regulation of JNK cascade; mitogen-activated protein kinase kinase binding;
PAK1	5	protein serine/threonine kinase activity; dendrite; apoptotic process; cytoplasm; ATP binding;
PAK7	5	protein serine/threonine kinase activity; cell migration; apoptotic process; ATP binding; nucleus;
PRKCB	5	protein serine/threonine kinase activity; apoptotic process; cytoplasm; ATP binding; nucleus;
PRKD1	5	protein serine/threonine kinase activity; apoptotic process; cytoplasm; ATP binding; nucleus;
RPS6KA4	5	protein serine/threonine kinase activity; nucleolus; cytoplasm; ATP binding; nucleus;
SMG1	5	protein serine/threonine kinase activity; response to stress; cytoplasm; ATP binding; nucleus;
APC	5	cell migration; response to DNA damage stimulus; apoptotic process; cytoplasm; nucleus;
FGD3	5	actin cytoskeleton organization; regulation of cell shape; apoptotic process; cytoskeleton; cytoplasm;
NF2	5	actin cytoskeleton organization; cytoskeleton; nucleolus; cytoplasm; nucleus;
AATF	5	response to DNA damage stimulus; apoptotic process; nucleolus; cytoplasm; nucleus;
CHD1L	5	response to DNA damage stimulus; nucleolus; cytoplasm; ATP binding; nucleus;

Genes shared at least 2 KEGG pathways with TAOK2 (count: 0)

View in gBrowse

Region: chr16:29985222..30003582 View in gBrowse