ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	APOA4
Approved Name	apolipoprotein A-IV
Location	11q23-qter
Position	chr11:116691418-116694022, -
External Links	HGNC: 602 Entrez Gene: 337 Ensembl: ENSG00000110244 UCSC: uc001pps.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 46)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 46)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005788	endoplasmic reticulum lumen	Cellular Component		33
GO:0005615	extracellular space	Cellular Component		126
GO:0006869	lipid transport	Biological Process	IDA[1935934]	12
GO:0006629	lipid metabolic process	Biological Process		51
GO:0005319	lipid transporter activity	Molecular Function	TAS[3080432]	2
GO:0002227	innate immune response in mucosa	Biological Process	IDA[15254593]	1
GO:0005576	extracellular region	Cellular Component	NAS[14718574]	240
GO:0005507	copper ion binding	Molecular Function	IDA[16945374]	9
GO:0045723	positive regulation of fatty acid biosynthetic process	Biological Process	IDA[2307668]	4
GO:0046470	phosphatidylcholine metabolic process	Biological Process	IDA[1935934]	2
GO:0051006	positive regulation of lipoprotein lipase activity	Biological Process	IDA[2307668]	3
GO:0055088	lipid homeostasis	Biological Process	IDA[3095477]	4
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	Molecular Function	IDA[1935934]	2
GO:0065005	protein-lipid complex assembly	Biological Process	IMP[16159879]	1
GO:0042803	protein homodimerization activity	Molecular Function	IDA[1935934]	113
GO:0042744	hydrogen peroxide catabolic process	Biological Process	IDA[16945374]	5
GO:0042632	cholesterol homeostasis	Biological Process	IDA[1935934]	18
GO:0042627	chylomicron	Cellular Component	IDA[3095477]	5
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0044240	multicellular organismal lipid catabolic process	Biological Process	IDA[3095477]	2
GO:0043691	reverse cholesterol transport	Biological Process	IDA[3095477]	7
GO:0043499	eukaryotic cell surface binding	Molecular Function	IDA[1935934]	1
GO:0034375	high-density lipoprotein particle remodeling	Biological Process	IC[1935934]	5
GO:0034372	very-low-density lipoprotein particle remodeling	Biological Process	IDA[2307668]	3
GO:0034371	chylomicron remodeling	Biological Process	IC[2307668]	3
GO:0034364	high-density lipoprotein particle	Cellular Component	IDA[3095477]	3
GO:0042157	lipoprotein metabolic process	Biological Process		11
GO:0035634	response to stilbenoid	Biological Process		1
GO:0034445	negative regulation of plasma lipoprotein particle oxidation	Biological Process	IDA[16945374]	1
GO:0034378	chylomicron assembly	Biological Process	TAS[16159879]	1
GO:0030300	regulation of intestinal cholesterol absorption	Biological Process		2
GO:0031210	phosphatidylcholine binding	Molecular Function	IDA[1935934]	2
GO:0017127	cholesterol transporter activity	Molecular Function	IDA[1935934]	5
GO:0019430	removal of superoxide radicals	Biological Process	IDA[16945374]	4
GO:0033700	phospholipid efflux	Biological Process	IDA[11162594]	5
GO:0034361	very-low-density lipoprotein particle	Cellular Component	IDA[17154273]	6
GO:0032374	regulation of cholesterol transport	Biological Process	IDA[11940599]	1
GO:0033344	cholesterol efflux	Biological Process	IDA[11162594]	8
GO:0008203	cholesterol metabolic process	Biological Process	IDA[1935934]	16
GO:0008289	lipid binding	Molecular Function	IMP[16159879]	23
GO:0006982	response to lipid hydroperoxide	Biological Process	IDA[16945374]	1
GO:0007159	leukocyte cell-cell adhesion	Biological Process	IDA[15254593]	5
GO:0010898	positive regulation of triglyceride catabolic process	Biological Process	IDA[2307668]	4
GO:0016209	antioxidant activity	Molecular Function	IDA[16945374]	3
GO:0009986	cell surface	Cellular Component	IDA[1935934]	70
GO:0010873	positive regulation of cholesterol esterification	Biological Process	IDA[1935934]	2

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04975	Fat digestion and absorption	19	Fat is an important energy source from food. More than 95% o...... Fat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, dietary TAG is hydrolyzed to fatty acids (FA) and monoacylglycerols (MAG) by pancreatic lipase. These products are then emulsified with the help of phospholipids (PL) and bile acids (BA) present in bile to form micelles. Free FAs and MAGs are taken up by the enterocyte where they are rapidly resynthesized in endoplasmic reticulum (ER) to form TAG. PLs from the diet as well as bile - mainly LPA - too are absorbed by the enterocyte and are acylated to form phosphatidic acid (PA), which is also converted into TAG. Absorbed cholesterol (CL) is acylated to cholesterol esters (CE). Within the ER, TAG joins CE and apolipoprotein B (ApoB) to form chylomicrons that enter circulation through the lymph. More...
hsa04977	Vitamin digestion and absorption	7	Vitamins are a diverse and chemically unrelated group of org...... Vitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactions. Because humans and other mammals cannot synthesize these compounds (except for some synthesis of niacin), they must obtain them from exogenous sources via intestinal absorption. Vitamins are classified based on their solubility in water or fat. Most of the water-soluble vitamins are transported across the small intestinal membrane by carrier-mediated mechanisms, but vitamin B12, cobalamin, is transported by a receptor-mediated mechanism. Intestinal absorption of fat-soluble vitamins requires all of the processes needed for fat absorption. After digestion, these vitamins and the products of pancreatic hydrolysis of triglycerides (TG) are emulsified by bile salts to form mixed micelles which are taken up by intestinal enterocytes and incorporated into chylomicrons (CM). CM are then secreted into the lymphatic system, and finally moves into the plasma. More...

Genes shared at least 5 GO terms with APOA4 (count: 12)

Gene Symbol	Pathway Count	Pathway List
APOA1	18	endoplasmic reticulum lumen; extracellular space; lipid metabolic process; extracellular region; phosphatidylcholine-sterol O-acyltransferase activator activity; cholesterol homeostasis; small molecule metabolic process; reverse cholesterol transport; high-density lipoprotein particle remodeling; high-density lipoprotein particle; lipoprotein metabolic process; regulation of intestinal cholesterol absorption; cholesterol transporter activity; phospholipid efflux; very-low-density lipoprotein particle; cholesterol efflux; cholesterol metabolic process; positive regulation of cholesterol esterification;
APOC2	18	extracellular space; lipid metabolic process; extracellular region; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; protein homodimerization activity; cholesterol homeostasis; chylomicron; small molecule metabolic process; reverse cholesterol transport; very-low-density lipoprotein particle remodeling; chylomicron remodeling; lipoprotein metabolic process; phospholipid efflux; very-low-density lipoprotein particle; cholesterol efflux; lipid binding; positive regulation of triglyceride catabolic process;
APOA5	14	extracellular space; lipid transport; extracellular region; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; cholesterol homeostasis; chylomicron; small molecule metabolic process; high-density lipoprotein particle; lipoprotein metabolic process; phosphatidylcholine binding; very-low-density lipoprotein particle; lipid binding; positive regulation of triglyceride catabolic process;
APOC3	13	extracellular space; lipid metabolic process; extracellular region; cholesterol homeostasis; chylomicron; small molecule metabolic process; reverse cholesterol transport; high-density lipoprotein particle remodeling; lipoprotein metabolic process; phospholipid efflux; very-low-density lipoprotein particle; cholesterol efflux; cholesterol metabolic process;
LPL	10	extracellular space; lipid metabolic process; extracellular region; chylomicron; small molecule metabolic process; very-low-density lipoprotein particle remodeling; chylomicron remodeling; lipoprotein metabolic process; very-low-density lipoprotein particle; cell surface;
ABCA1	9	lipid metabolic process; cholesterol homeostasis; small molecule metabolic process; reverse cholesterol transport; lipoprotein metabolic process; cholesterol transporter activity; phospholipid efflux; cholesterol efflux; cholesterol metabolic process;
SCARB1	9	lipid metabolic process; protein homodimerization activity; cholesterol homeostasis; small molecule metabolic process; reverse cholesterol transport; high-density lipoprotein particle remodeling; lipoprotein metabolic process; cholesterol efflux; cell surface;
ACHE	6	endoplasmic reticulum lumen; extracellular space; extracellular region; protein homodimerization activity; small molecule metabolic process; cell surface;
APOL4	5	extracellular space; lipid transport; lipid metabolic process; lipoprotein metabolic process; lipid binding;
LIPG	5	extracellular space; lipid metabolic process; cholesterol homeostasis; reverse cholesterol transport; high-density lipoprotein particle remodeling;
PLA2G1B	5	extracellular space; extracellular region; phosphatidylcholine metabolic process; small molecule metabolic process; multicellular organismal lipid catabolic process;
CUBN	5	lipid metabolic process; protein homodimerization activity; small molecule metabolic process; lipoprotein metabolic process; cholesterol metabolic process;

Genes shared at least 2 KEGG pathways with APOA4 (count: 3)

Gene Symbol	Pathway Count	Pathway List
APOA1	2	Fat digestion and absorption; Vitamin digestion and absorption;
PNLIP	2	Fat digestion and absorption; Vitamin digestion and absorption;
SCARB1	2	Fat digestion and absorption; Vitamin digestion and absorption;

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Region: chr11:116691418..116694022 View in gBrowse