ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	APOC3
Approved Name	apolipoprotein C-III
Location	11q23-qter
Position	chr11:116700422-116703788, +
External Links	HGNC: 610 Entrez Gene: 345 Ensembl: ENSG00000110245 UCSC: uc001ppt.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 44)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 44)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005543	phospholipid binding	Molecular Function	IDA[11060345]	61
GO:0005576	extracellular region	Cellular Component		240
GO:0005615	extracellular space	Cellular Component	IDA[11060345]	126
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	IDA[16443932]	72
GO:0007584	response to nutrient	Biological Process		15
GO:0008203	cholesterol metabolic process	Biological Process		16
GO:0010897	negative regulation of triglyceride catabolic process	Biological Process	IDA[3973011]	2
GO:0006629	lipid metabolic process	Biological Process		51
GO:0006641	triglyceride metabolic process	Biological Process	IMP[17142127]	8
GO:0006642	triglyceride mobilization	Biological Process		2
GO:0006954	inflammatory response	Biological Process		51
GO:0070653	high-density lipoprotein particle receptor binding	Molecular Function	IPI[9254056]	2
GO:0042627	chylomicron	Cellular Component	IDA[8245722]	5
GO:0042632	cholesterol homeostasis	Biological Process	IMP[18767813]	18
GO:0042157	lipoprotein metabolic process	Biological Process		11
GO:0042493	response to drug	Biological Process		68
GO:0043691	reverse cholesterol transport	Biological Process	IC[15778093]	7
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0042953	lipoprotein transport	Biological Process		3
GO:0043434	response to peptide hormone stimulus	Biological Process		9
GO:0048261	negative regulation of receptor-mediated endocytosis	Biological Process	IDA[1917954]	4
GO:0050995	negative regulation of lipid catabolic process	Biological Process	IDA[15576844]	5
GO:0045717	negative regulation of fatty acid biosynthetic process	Biological Process	IDA[18635818]	1
GO:0045833	negative regulation of lipid metabolic process	Biological Process	IDA[182536]	2
GO:0060621	negative regulation of cholesterol import	Biological Process	IMP[15778093]	1
GO:0070328	triglyceride homeostasis	Biological Process	IMP[18767813]	7
GO:0051005	negative regulation of lipoprotein lipase activity	Biological Process	IDA[3973011]	2
GO:0055102	lipase inhibitor activity	Molecular Function	IDA[3973011]	3
GO:0010989	negative regulation of low-density lipoprotein particle clearance	Biological Process	IMP[15778093]	1
GO:0010987	negative regulation of high-density lipoprotein particle clearance	Biological Process	IMP[15778093]	1
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	Biological Process	IDA[1917954]	2
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	Biological Process	IC[18635818]; IDA[3973011]	2
GO:0032489	regulation of Cdc42 protein signal transduction	Biological Process	IDA[16443932]	3
GO:0030234	enzyme regulator activity	Molecular Function	IDA[11060345]	1
GO:0019433	triglyceride catabolic process	Biological Process	IDA[11060345]	7
GO:0015485	cholesterol binding	Molecular Function	IC[11162594]	10
GO:0034363	intermediate-density lipoprotein particle	Cellular Component	IDA[17336988]	2
GO:0034361	very-low-density lipoprotein particle	Cellular Component	IDA[17154273]	6
GO:0033700	phospholipid efflux	Biological Process	IDA[11162594]	5
GO:0033344	cholesterol efflux	Biological Process	IDA[11162594]	8
GO:0034382	chylomicron remnant clearance	Biological Process	IDA[4020294]	2
GO:0034379	very-low-density lipoprotein particle assembly	Biological Process	TAS[18399797]	2
GO:0034375	high-density lipoprotein particle remodeling	Biological Process	IMP[17438339]	5
GO:0034366	spherical high-density lipoprotein particle	Cellular Component	IDA[17438339]	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03320	PPAR signaling pathway	12	Peroxisome proliferator-activated receptors (PPARs) are nucl...... Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. More...

Genes shared at least 5 GO terms with APOC3 (count: 13)

Gene Symbol	Pathway Count	Pathway List
APOA1	23	phospholipid binding; extracellular region; extracellular space; G-protein coupled receptor signaling pathway; response to nutrient; cholesterol metabolic process; lipid metabolic process; high-density lipoprotein particle receptor binding; cholesterol homeostasis; lipoprotein metabolic process; response to drug; reverse cholesterol transport; small molecule metabolic process; triglyceride homeostasis; lipase inhibitor activity; negative regulation of very-low-density lipoprotein particle remodeling; regulation of Cdc42 protein signal transduction; cholesterol binding; very-low-density lipoprotein particle; phospholipid efflux; cholesterol efflux; high-density lipoprotein particle remodeling; spherical high-density lipoprotein particle;
APOC2	19	extracellular region; extracellular space; lipid metabolic process; chylomicron; cholesterol homeostasis; lipoprotein metabolic process; reverse cholesterol transport; small molecule metabolic process; negative regulation of receptor-mediated endocytosis; negative regulation of lipid metabolic process; triglyceride homeostasis; lipase inhibitor activity; negative regulation of very-low-density lipoprotein particle clearance; intermediate-density lipoprotein particle; very-low-density lipoprotein particle; phospholipid efflux; cholesterol efflux; chylomicron remnant clearance; spherical high-density lipoprotein particle;
APOA4	13	extracellular region; extracellular space; cholesterol metabolic process; lipid metabolic process; chylomicron; cholesterol homeostasis; lipoprotein metabolic process; reverse cholesterol transport; small molecule metabolic process; very-low-density lipoprotein particle; phospholipid efflux; cholesterol efflux; high-density lipoprotein particle remodeling;
ABCA1	12	phospholipid binding; G-protein coupled receptor signaling pathway; cholesterol metabolic process; lipid metabolic process; cholesterol homeostasis; lipoprotein metabolic process; reverse cholesterol transport; small molecule metabolic process; regulation of Cdc42 protein signal transduction; cholesterol binding; phospholipid efflux; cholesterol efflux;
APOA5	11	phospholipid binding; extracellular region; extracellular space; triglyceride metabolic process; chylomicron; cholesterol homeostasis; lipoprotein metabolic process; small molecule metabolic process; triglyceride homeostasis; triglyceride catabolic process; very-low-density lipoprotein particle;
LPL	11	extracellular region; extracellular space; lipid metabolic process; triglyceride metabolic process; chylomicron; lipoprotein metabolic process; response to drug; small molecule metabolic process; triglyceride homeostasis; triglyceride catabolic process; very-low-density lipoprotein particle;
SCARB1	8	lipid metabolic process; cholesterol homeostasis; lipoprotein metabolic process; reverse cholesterol transport; small molecule metabolic process; triglyceride homeostasis; cholesterol efflux; high-density lipoprotein particle remodeling;
NPC1	6	extracellular region; cholesterol metabolic process; cholesterol homeostasis; response to drug; cholesterol binding; cholesterol efflux;
LIPG	6	extracellular space; response to nutrient; lipid metabolic process; cholesterol homeostasis; reverse cholesterol transport; high-density lipoprotein particle remodeling;
INS	5	extracellular region; extracellular space; G-protein coupled receptor signaling pathway; small molecule metabolic process; negative regulation of lipid catabolic process;
NGF	5	extracellular region; extracellular space; inflammatory response; response to drug; response to peptide hormone stimulus;
PNLIPRP2	5	extracellular region; extracellular space; lipid metabolic process; triglyceride metabolic process; small molecule metabolic process;
CUBN	5	cholesterol metabolic process; lipid metabolic process; lipoprotein metabolic process; small molecule metabolic process; lipoprotein transport;

Genes shared at least 2 KEGG pathways with APOC3 (count: 0)

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Region: chr11:116700422..116703788 View in gBrowse