ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CXCR2
Previous Symbol	IL8RB
Symbol Alias	CMKAR2, CD182
Approved Name	chemokine (C-X-C motif) receptor 2
Previous Name	interleukin 8 receptor, beta
Location	2q35
Position	chr2:218990012-219001976, +
External Links	HGNC: 6027 Entrez Gene: 3579 Ensembl: ENSG00000180871 UCSC: uc002vha.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0002407	dendritic cell chemotaxis	Biological Process	TAS[16621978]	5
GO:0006935	chemotaxis	Biological Process	IDA[10725748]	15
GO:0006954	inflammatory response	Biological Process	TAS[9725262]	51
GO:0005887	integral to plasma membrane	Cellular Component	TAS[10438939]	220
GO:0006915	apoptotic process	Biological Process		111
GO:0005622	intracellular	Cellular Component	IDA[10878382]	67
GO:0005886	plasma membrane	Cellular Component		772
GO:0004871	signal transducer activity	Molecular Function	IDA[10878382]	49
GO:0004918	interleukin-8 receptor activity	Molecular Function	IDA[10820279]	2
GO:0016020	membrane	Cellular Component	IDA[10725748]	139
GO:0009986	cell surface	Cellular Component	IDA[10878382]	70
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA[10438939]	69
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process		20
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	Biological Process	IDA[10438939]	12
GO:0007166	cell surface receptor signaling pathway	Biological Process	IDA[10734056]	35
GO:0007165	signal transduction	Biological Process	IDA[10820279]	171
GO:0006968	cellular defense response	Biological Process	IDA[10725748]	12
GO:0042629	mast cell granule	Cellular Component	IDA[9725262]	1
GO:0042119	neutrophil activation	Biological Process	IDA[10878382]	2
GO:0038112	interleukin-8-mediated signaling pathway	Biological Process	IDA[10820279]	2
GO:0031623	receptor internalization	Biological Process	IDA[10734056]	10
GO:0030593	neutrophil chemotaxis	Biological Process	IDA[10820279]	7
GO:0019959	interleukin-8 binding	Molecular Function	IPI[1840701]	2
GO:0016494	C-X-C chemokine receptor activity	Molecular Function	IDA[10878382]	2

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04144	Endocytosis	39	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16	Two major virulence factors of H. pylori are the vacuolating...... Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA). More...
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

Genes shared at least 5 GO terms with CXCR2 (count: 14)

Gene Symbol	Pathway Count	Pathway List
CXCR1	10	dendritic cell chemotaxis; chemotaxis; inflammatory response; plasma membrane; interleukin-8 receptor activity; membrane; cell surface receptor signaling pathway; interleukin-8-mediated signaling pathway; receptor internalization; interleukin-8 binding;
CCR5	9	dendritic cell chemotaxis; chemotaxis; inflammatory response; integral to plasma membrane; plasma membrane; cell surface; elevation of cytosolic calcium ion concentration; cell surface receptor signaling pathway; cellular defense response;
SPN	7	chemotaxis; integral to plasma membrane; plasma membrane; cell surface; cell surface receptor signaling pathway; signal transduction; cellular defense response;
PIK3CG	6	dendritic cell chemotaxis; inflammatory response; plasma membrane; membrane; elevation of cytosolic calcium ion concentration; neutrophil chemotaxis;
ADORA2A	6	inflammatory response; integral to plasma membrane; apoptotic process; plasma membrane; membrane; cellular defense response;
ADRA1A	6	integral to plasma membrane; apoptotic process; plasma membrane; elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway; signal transduction;
CCKBR	6	integral to plasma membrane; plasma membrane; positive regulation of cell proliferation; elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway; cell surface receptor signaling pathway;
EDNRA	6	integral to plasma membrane; plasma membrane; membrane; positive regulation of cell proliferation; elevation of cytosolic calcium ion concentration; signal transduction;
C3AR1	5	chemotaxis; inflammatory response; integral to plasma membrane; plasma membrane; elevation of cytosolic calcium ion concentration;
BDKRB2	5	inflammatory response; integral to plasma membrane; plasma membrane; elevation of cytosolic calcium ion concentration; cell surface receptor signaling pathway;
PRKD1	5	inflammatory response; integral to plasma membrane; apoptotic process; plasma membrane; signal transduction;
S1PR3	5	inflammatory response; integral to plasma membrane; plasma membrane; positive regulation of cell proliferation; elevation of cytosolic calcium ion concentration;
CHRM1	5	integral to plasma membrane; plasma membrane; membrane; positive regulation of cell proliferation; signal transduction;
GJA1	5	integral to plasma membrane; apoptotic process; plasma membrane; signal transducer activity; signal transduction;

Genes shared at least 2 KEGG pathways with CXCR2 (count: 14)

Gene Symbol	Pathway Count	Pathway List
CXCR1	4	Endocytosis; Epithelial cell signaling in Helicobacter pylori infection; Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CCR5	3	Endocytosis; Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
ADRBK1	2	Endocytosis; Chemokine signaling pathway;
ADRBK2	2	Endocytosis; Chemokine signaling pathway;
ARRB1	2	Endocytosis; Chemokine signaling pathway;
ARRB2	2	Endocytosis; Chemokine signaling pathway;
GIT1	2	Endocytosis; Epithelial cell signaling in Helicobacter pylori infection;
TGFBR1	2	Endocytosis; Cytokine-cytokine receptor interaction;
PAK1	2	Epithelial cell signaling in Helicobacter pylori infection; Chemokine signaling pathway;
RELA	2	Epithelial cell signaling in Helicobacter pylori infection; Chemokine signaling pathway;
CCL19	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CCL27	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCL12	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
CXCR5	2	Chemokine signaling pathway; Cytokine-cytokine receptor interaction;

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Region: chr2:218990012..219001976 View in gBrowse