ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NADSYN1
Symbol Alias	FLJ10631
Approved Name	NAD synthetase 1
Location	11q13.4
Position	chr11:71164155-71239227, +
External Links	HGNC: 29832 Entrez Gene: 55191 Ensembl: ENSG00000172890 UCSC: uc001oqn.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Neale BM, 2010 (a)	1 SNPs of top 50 hits located within the gene	Trend

Gene related SNPs (count: 30)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs7928249	Chr11:71161063(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/0/1)
rs12800438	Chr11:71171003(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	1(0/0/1)

LD-proxies (count: 28)

rs_ID	Location	Functional Annotation
rs12791871	Chr11:71164544(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs7944926	Chr11:71165625(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs1629220	Chr11:71174553(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs1792226	Chr11:71176574(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs1792229	Chr11:71179395(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs3794060	Chr11:71187679(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs4945008	Chr11:71221248(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs11233747	Chr11:71171642(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs2002064	Chr11:71163420(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs4423214	Chr11:71173254(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs2040323	Chr11:71172783(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs2276362	Chr11:71174452(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs11600569	Chr11:71173747(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs2282620	Chr11:71183477(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs2282621	Chr11:71183474(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs4944062	Chr11:71187294(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs7935125	Chr11:71184190(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs1792234	Chr11:71182018(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs4944957	Chr11:71168035(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs1540127	Chr11:71179038(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs12785878	Chr11:71167449(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs1790343	Chr11:71177207(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs4944959	Chr11:71168234(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs4944958	Chr11:71168073(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs7938885	Chr11:71170043(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs2276360	Chr11:71169547(Fwd)	NMD_transcript_variant; downstream_gene_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant
rs12790558	Chr11:71170905(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs12808368	Chr11:71170817(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 9)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 9)

ID	Name	Type	No. of Genes in ADHDgene
GO:0009435	NAD biosynthetic process	Biological Process	6
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Molecular Function	2
GO:0019674	NAD metabolic process	Biological Process	5
GO:0044281	small molecule metabolic process	Biological Process	248
GO:0005829	cytosol	Cellular Component	447
GO:0005524	ATP binding	Molecular Function	228
GO:0006767	water-soluble vitamin metabolic process	Biological Process	13
GO:0006766	vitamin metabolic process	Biological Process	13
GO:0003952	NAD+ synthase (glutamine-hydrolyzing) activity	Molecular Function	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00760	Nicotinate and nicotinamide metabolism	9

Genes shared at least 5 GO terms with NADSYN1 (count: 4)

Gene Symbol	Pathway Count	Pathway List
NMNAT3	7	NAD biosynthetic process; NAD metabolic process; small molecule metabolic process; cytosol; ATP binding; water-soluble vitamin metabolic process; vitamin metabolic process;
NAPRT1	6	NAD biosynthetic process; NAD metabolic process; small molecule metabolic process; cytosol; water-soluble vitamin metabolic process; vitamin metabolic process;
NMNAT2	6	NAD biosynthetic process; NAD metabolic process; small molecule metabolic process; ATP binding; water-soluble vitamin metabolic process; vitamin metabolic process;
QPRT	6	NAD biosynthetic process; NAD metabolic process; small molecule metabolic process; cytosol; water-soluble vitamin metabolic process; vitamin metabolic process;

Genes shared at least 2 KEGG pathways with NADSYN1 (count: 8)

Gene Symbol	Pathway Count	Pathway List
ENPP1	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
ENPP3	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NAPRT1	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NMNAT2	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NMNAT3	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NNMT	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NT5M	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
QPRT	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;

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Region: chr11:71164155..71239227 View in gBrowse