ADHDgene Database

Gene Report

Basic Info

Approved Symbol	QPRT
Symbol Alias	QPRTase
Approved Name	quinolinate phosphoribosyltransferase
Name Alias	nicotinate-nucleotide pyrophosphorylase (carboxylating)
Location	16p11.2
Position	chr16:29674600-29709325, +
External Links	HGNC: 9755 Entrez Gene: 23475 Ensembl: ENSG00000103485 UCSC: uc002dto.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 4)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_16	chr16:29563594-30367556 (NCBI Build 36.1 (hg18))	803963	16p11.2	Loss
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain
CNV_Jarick[2012]_35	chr16:29554843-30085308 (NCBI36 / hg18)	530466	16p11.2	del

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Molecular Function	IDA[9473669]	2
GO:0006766	vitamin metabolic process	Biological Process		13
GO:0005829	cytosol	Cellular Component		447
GO:0009435	NAD biosynthetic process	Biological Process		6
GO:0006767	water-soluble vitamin metabolic process	Biological Process		13
GO:0042803	protein homodimerization activity	Molecular Function	IDA[17868694]	113
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0019674	NAD metabolic process	Biological Process		5
GO:0034213	quinolinate catabolic process	Biological Process	IDA[9473669]	1
GO:0051259	protein oligomerization	Biological Process	IDA[17868694]	8

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00760	Nicotinate and nicotinamide metabolism	9

Genes shared at least 5 GO terms with QPRT (count: 5)

Gene Symbol	Pathway Count	Pathway List
NAPRT1	7	nicotinate-nucleotide diphosphorylase (carboxylating) activity; vitamin metabolic process; cytosol; NAD biosynthetic process; water-soluble vitamin metabolic process; small molecule metabolic process; NAD metabolic process;
NADSYN1	6	vitamin metabolic process; cytosol; NAD biosynthetic process; water-soluble vitamin metabolic process; small molecule metabolic process; NAD metabolic process;
NMNAT3	6	vitamin metabolic process; cytosol; NAD biosynthetic process; water-soluble vitamin metabolic process; small molecule metabolic process; NAD metabolic process;
NMNAT2	5	vitamin metabolic process; NAD biosynthetic process; water-soluble vitamin metabolic process; small molecule metabolic process; NAD metabolic process;
SHMT1	5	vitamin metabolic process; cytosol; water-soluble vitamin metabolic process; protein homodimerization activity; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with QPRT (count: 8)

Gene Symbol	Pathway Count	Pathway List
ENPP1	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
ENPP3	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NADSYN1	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NAPRT1	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NMNAT2	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NMNAT3	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NNMT	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NT5M	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;

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Region: chr16:29674600..29709325 View in gBrowse