ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ENPP1
Previous Symbol	NPPS, M6S1, PDNP1
Symbol Alias	PC-1, PCA1
Approved Name	ectonucleotide pyrophosphatase/phosphodiesterase 1
Location	6q22-q23
Position	chr6:132129156-132216295, +
External Links	HGNC: 3356 Entrez Gene: 5167 Ensembl: ENSG00000197594 UCSC: uc011ecf.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 41)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 41)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004528	phosphodiesterase I activity	Molecular Function		3
GO:0004551	nucleotide diphosphatase activity	Molecular Function	IDA[12746903]	2
GO:0005044	scavenger receptor activity	Molecular Function		11
GO:0005158	insulin receptor binding	Molecular Function	IDA[7830796]	6
GO:0003676	nucleic acid binding	Molecular Function		41
GO:0006091	generation of precursor metabolites and energy	Biological Process	IDA[12746903]	7
GO:0006766	vitamin metabolic process	Biological Process		13
GO:0006767	water-soluble vitamin metabolic process	Biological Process		13
GO:0006771	riboflavin metabolic process	Biological Process		1
GO:0005515	protein binding	Molecular Function	IPI[11289049]	910
GO:0005524	ATP binding	Molecular Function	IDA[7830796]	228
GO:0005615	extracellular space	Cellular Component	IDA[11159191]	126
GO:0005886	plasma membrane	Cellular Component	IDA[10513816]	772
GO:0046627	negative regulation of insulin receptor signaling pathway	Biological Process	IDA[17849011]	5
GO:0046849	bone remodeling	Biological Process		6
GO:0045719	negative regulation of glycogen biosynthetic process	Biological Process	IDA[11289049]	3
GO:0046325	negative regulation of glucose import	Biological Process	IDA[17849011]	2
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0045599	negative regulation of fat cell differentiation	Biological Process	IDA[17849011]	5
GO:0035529	NADH pyrophosphatase activity	Molecular Function		2
GO:0042803	protein homodimerization activity	Molecular Function	IDA[7830796]	113
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process	Biological Process	IDA[7830796]	2
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding	Molecular Function	IC[7830796]	3
GO:0046872	metal ion binding	Molecular Function		170
GO:0047429	nucleoside-triphosphate diphosphatase activity	Molecular Function	IDA[11159191]	3
GO:0030279	negative regulation of ossification	Biological Process		4
GO:0030247	polysaccharide binding	Molecular Function		3
GO:0016323	basolateral plasma membrane	Cellular Component	NAS[9553761]	29
GO:0016021	integral to membrane	Cellular Component		845
GO:0009986	cell surface	Cellular Component	IDA[10513816]	70
GO:0009143	nucleoside triphosphate catabolic process	Biological Process	IDA[10513816]	3
GO:0006955	immune response	Biological Process		45
GO:0006796	phosphate-containing compound metabolic process	Biological Process	IDA[11159191]	3
GO:0032869	cellular response to insulin stimulus	Biological Process	IDA[17849011]	7
GO:0031953	negative regulation of protein autophosphorylation	Biological Process	IDA[11289049]	1
GO:0031214	biomineral tissue development	Biological Process		1
GO:0030730	sequestering of triglyceride	Biological Process	IDA[17849011]	1
GO:0030643	cellular phosphate ion homeostasis	Biological Process	IDA[11159191]	2
GO:0030505	inorganic diphosphate transport	Biological Process	IDA[10513816]	2
GO:0030500	regulation of bone mineralization	Biological Process	IC[10513816]	1
GO:0030308	negative regulation of cell growth	Biological Process	IDA[17849011]	21

Gene related KEGG pathways (count: 6)

ID	Name	No. of Genes in ADHDgene
hsa00230	Purine metabolism	22
hsa01100	Metabolic pathways	237
hsa00740	Riboflavin metabolism	4
hsa00770	Pantothenate and CoA biosynthesis	7
hsa00500	Starch and sucrose metabolism	26
hsa00760	Nicotinate and nicotinamide metabolism	9

Genes shared at least 5 GO terms with ENPP1 (count: 21)

Gene Symbol	Pathway Count	Pathway List
ENPP3	12	phosphodiesterase I activity; nucleotide diphosphatase activity; scavenger receptor activity; nucleic acid binding; NADH pyrophosphatase activity; metal ion binding; nucleoside-triphosphate diphosphatase activity; polysaccharide binding; nucleoside triphosphate catabolic process; immune response; phosphate-containing compound metabolic process; inorganic diphosphate transport;
GHR	7	protein binding; extracellular space; plasma membrane; protein homodimerization activity; integral to membrane; cell surface; cellular response to insulin stimulus;
GRB10	6	insulin receptor binding; protein binding; plasma membrane; negative regulation of insulin receptor signaling pathway; negative regulation of glycogen biosynthetic process; negative regulation of glucose import;
ABCG2	6	protein binding; ATP binding; plasma membrane; small molecule metabolic process; protein homodimerization activity; integral to membrane;
ACHE	6	protein binding; extracellular space; plasma membrane; small molecule metabolic process; protein homodimerization activity; cell surface;
ADCY4	6	protein binding; ATP binding; plasma membrane; small molecule metabolic process; metal ion binding; integral to membrane;
CRYAB	6	protein binding; plasma membrane; protein homodimerization activity; metal ion binding; cell surface; negative regulation of cell growth;
SLC2A3	5	vitamin metabolic process; water-soluble vitamin metabolic process; plasma membrane; small molecule metabolic process; integral to membrane;
ADRA2A	5	protein binding; plasma membrane; small molecule metabolic process; protein homodimerization activity; basolateral plasma membrane;
CACNA1A	5	protein binding; plasma membrane; small molecule metabolic process; metal ion binding; integral to membrane;
CACNA1C	5	protein binding; plasma membrane; small molecule metabolic process; metal ion binding; integral to membrane;
CADM1	5	protein binding; plasma membrane; protein homodimerization activity; basolateral plasma membrane; integral to membrane;
ERBB2	5	protein binding; ATP binding; plasma membrane; basolateral plasma membrane; integral to membrane;
JAM3	5	protein binding; extracellular space; plasma membrane; protein homodimerization activity; integral to membrane;
LPL	5	protein binding; extracellular space; plasma membrane; small molecule metabolic process; cell surface;
NRXN1	5	protein binding; plasma membrane; metal ion binding; integral to membrane; cell surface;
PRKD1	5	protein binding; ATP binding; plasma membrane; small molecule metabolic process; metal ion binding;
PVRL1	5	protein binding; plasma membrane; protein homodimerization activity; integral to membrane; immune response;
STX4	5	protein binding; plasma membrane; basolateral plasma membrane; integral to membrane; cell surface;
FURIN	5	extracellular space; plasma membrane; metal ion binding; integral to membrane; cell surface;
PRLR	5	plasma membrane; protein homodimerization activity; metal ion binding; integral to membrane; cell surface;

Genes shared at least 2 KEGG pathways with ENPP1 (count: 43)

Gene Symbol	Pathway Count	Pathway List
ENPP3	6	Purine metabolism; Metabolic pathways; Riboflavin metabolism; Pantothenate and CoA biosynthesis; Starch and sucrose metabolism; Nicotinate and nicotinamide metabolism;
NT5M	3	Purine metabolism; Metabolic pathways; Nicotinate and nicotinamide metabolism;
APRT	2	Purine metabolism; Metabolic pathways;
ATIC	2	Purine metabolism; Metabolic pathways;
ITPA	2	Purine metabolism; Metabolic pathways;
POLA2	2	Purine metabolism; Metabolic pathways;
POLD3	2	Purine metabolism; Metabolic pathways;
POLD4	2	Purine metabolism; Metabolic pathways;
POLE	2	Purine metabolism; Metabolic pathways;
POLE3	2	Purine metabolism; Metabolic pathways;
POLR1A	2	Purine metabolism; Metabolic pathways;
POLR2G	2	Purine metabolism; Metabolic pathways;
RRM2	2	Purine metabolism; Metabolic pathways;
HK1	2	Metabolic pathways; Starch and sucrose metabolism;
HKDC1	2	Metabolic pathways; Starch and sucrose metabolism;
NADSYN1	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NAPRT1	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NMNAT2	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NMNAT3	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NNMT	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
PANK2	2	Metabolic pathways; Pantothenate and CoA biosynthesis;
QPRT	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
TYR	2	Metabolic pathways; Riboflavin metabolism;
UGT1A1	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A10	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A3	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A4	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A5	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A6	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A7	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A8	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A9	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2A1	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2A2	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2A3	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B10	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B11	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B15	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B17	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B28	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B4	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B7	2	Metabolic pathways; Starch and sucrose metabolism;
UPB1	2	Metabolic pathways; Pantothenate and CoA biosynthesis;

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Region: chr6:132129156..132216295 View in gBrowse