ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TRIO
Symbol Alias	ARHGEF23
Approved Name	triple functional domain (PTPRF interacting)
Location	5p14-p15.1
Position	chr5:14143811-14532235, +
External Links	HGNC: 12303 Entrez Gene: 7204 Ensembl: ENSG00000038382 UCSC: uc003jff.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Stergiakouli E., 2012	One of the top 20 independent SNPs with P=0.00000676 locates intronic relative to this gene.	Trend

Gene related SNPs (count: 30)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs42259	Chr5:14386655(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/0/1)

LD-proxies (count: 29)

rs_ID	Location	Functional Annotation
rs30634	Chr5:14300033(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs42204	Chr5:14301803(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs42405	Chr5:14312410(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs154154	Chr5:14317307(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs42551	Chr5:14321785(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs247142	Chr5:14325654(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs247143	Chr5:14325944(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs154152	Chr5:14380324(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs30770	Chr5:14378068(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs30769	Chr5:14377962(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs409214	Chr5:14373284(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs1664507	Chr5:14371539(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs256417	Chr5:14371180(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs30784	Chr5:14366840(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs30783	Chr5:14366369(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs42407	Chr5:14361471(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs154161	Chr5:14356028(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs476930	Chr5:14352595(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs256423	Chr5:14351024(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs247140	Chr5:14344689(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs247134	Chr5:14337460(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs39857	Chr5:14329966(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs247144	Chr5:14326476(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs30612	Chr5:14420027(Fwd)	NMD_transcript_variant; downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant
rs10513177	Chr5:14389545(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs39866	Chr5:14361009(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs256416	Chr5:14370831(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs30792	Chr5:14386494(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs154159	Chr5:14354827(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Molecular Function		11
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	TAS[8643598]	17
GO:0005524	ATP binding	Molecular Function		228
GO:0005515	protein binding	Molecular Function	IPI[17043677]	910
GO:0005829	cytosol	Cellular Component		447
GO:0005543	phospholipid binding	Molecular Function		61
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	Biological Process	TAS[8643598]	2
GO:0006915	apoptotic process	Biological Process		111
GO:0004674	protein serine/threonine kinase activity	Molecular Function		61
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process		30
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0035023	regulation of Rho protein signal transduction	Biological Process		9
GO:0007411	axon guidance	Biological Process		65
GO:0007264	small GTPase mediated signal transduction	Biological Process		58

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TRIO (count: 19)

Gene Symbol	Pathway Count	Pathway List
ARHGEF12	10	Rho guanyl-nucleotide exchange factor activity; protein binding; cytosol; phospholipid binding; apoptotic process; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; regulation of Rho protein signal transduction; axon guidance; small GTPase mediated signal transduction;
ARHGEF4	10	Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; protein binding; cytosol; phospholipid binding; apoptotic process; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; regulation of Rho protein signal transduction; small GTPase mediated signal transduction;
ARHGEF2	9	Rho guanyl-nucleotide exchange factor activity; protein binding; cytosol; phospholipid binding; apoptotic process; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; regulation of Rho protein signal transduction; small GTPase mediated signal transduction;
TIAM2	9	Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; cytosol; phospholipid binding; apoptotic process; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; regulation of Rho protein signal transduction; small GTPase mediated signal transduction;
ARHGEF17	8	Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; cytosol; apoptotic process; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; regulation of Rho protein signal transduction; small GTPase mediated signal transduction;
FGD3	8	Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; cytosol; phospholipid binding; apoptotic process; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction;
NET1	8	Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; cytosol; phospholipid binding; apoptotic process; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction;
MAPK1	8	ATP binding; protein binding; cytosol; apoptotic process; protein serine/threonine kinase activity; nerve growth factor receptor signaling pathway; axon guidance; small GTPase mediated signal transduction;
MCF2L	7	Rho guanyl-nucleotide exchange factor activity; cytosol; apoptotic process; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; regulation of Rho protein signal transduction; small GTPase mediated signal transduction;
MAPK3	7	ATP binding; protein binding; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; axon guidance; small GTPase mediated signal transduction;
GSK3B	6	ATP binding; protein binding; cytosol; protein serine/threonine kinase activity; nerve growth factor receptor signaling pathway; axon guidance;
PAK1	6	ATP binding; protein binding; cytosol; apoptotic process; protein serine/threonine kinase activity; axon guidance;
PRKD1	6	ATP binding; protein binding; cytosol; phospholipid binding; apoptotic process; protein serine/threonine kinase activity;
ROCK2	6	ATP binding; protein binding; cytosol; phospholipid binding; protein serine/threonine kinase activity; axon guidance;
ADRBK1	5	ATP binding; protein binding; cytosol; phospholipid binding; nerve growth factor receptor signaling pathway;
MAPK7	5	ATP binding; protein binding; cytosol; apoptotic process; nerve growth factor receptor signaling pathway;
PRKCB	5	ATP binding; protein binding; cytosol; apoptotic process; protein serine/threonine kinase activity;
BAD	5	protein binding; cytosol; phospholipid binding; apoptotic process; nerve growth factor receptor signaling pathway;
SQSTM1	5	protein binding; cytosol; apoptotic process; protein serine/threonine kinase activity; nerve growth factor receptor signaling pathway;

Genes shared at least 2 KEGG pathways with TRIO (count: 0)

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Region: chr5:14143811..14532235 View in gBrowse