ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ARHGEF2
Symbol Alias	LFP40, GEF-H1, KIAA0651, P40
Approved Name	Rho/Rac guanine nucleotide exchange factor (GEF) 2
Previous Name	rho/rac guanine nucleotide exchange factor (GEF) 2
Location	1q21-q22
Position	chr1:155916630-155966129, -
External Links	HGNC: 682 Entrez Gene: 9181 Ensembl: ENSG00000116584 UCSC: uc001fmt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 38)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051493	regulation of cytoskeleton organization	Biological Process		32
GO:0000226	microtubule cytoskeleton organization	Biological Process		39

GO terms by database search (count: 36)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005874	microtubule	Cellular Component		52
GO:0005923	tight junction	Cellular Component		15
GO:0005819	spindle	Cellular Component		29
GO:0005829	cytosol	Cellular Component		447
GO:0007015	actin filament organization	Biological Process	IMP[9857026]	12
GO:0007026	negative regulation of microtubule depolymerization	Biological Process	IMP[11912491]	7
GO:0006886	intracellular protein transport	Biological Process	NAS[9857026]	43
GO:0006915	apoptotic process	Biological Process		111
GO:0008017	microtubule binding	Molecular Function	IDA[9857026]	32
GO:0008134	transcription factor binding	Molecular Function		38
GO:0007067	mitosis	Biological Process		39
GO:0007264	small GTPase mediated signal transduction	Biological Process		58
GO:0030676	Rac guanyl-nucleotide exchange factor activity	Molecular Function	IDA[9857026]	3
GO:0032587	ruffle membrane	Cellular Component	IDA[19043560]	12
GO:0008270	zinc ion binding	Molecular Function	NAS[11912491]	323
GO:0017048	Rho GTPase binding	Molecular Function	IDA[9857026]	3
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0043025	neuronal cell body	Cellular Component		51
GO:0042127	regulation of cell proliferation	Biological Process	TAS[9857026]	20
GO:0035023	regulation of Rho protein signal transduction	Biological Process	NAS[11912491]	9
GO:0050768	negative regulation of neurogenesis	Biological Process		3
GO:0048365	Rac GTPase binding	Molecular Function	IDA[9857026]	5
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0043198	dendritic shaft	Cellular Component		11
GO:0051301	cell division	Biological Process		58
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IDA[19043560]	27
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process		30
GO:0071474	cellular hyperosmotic response	Biological Process		1
GO:0071356	cellular response to tumor necrosis factor	Biological Process		9
GO:0060547	negative regulation of necrotic cell death	Biological Process		2
GO:0005543	phospholipid binding	Molecular Function		61
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Molecular Function	IDA[9857026]	11
GO:0005515	protein binding	Molecular Function	IPI[19043560]	910
GO:0000902	cell morphogenesis	Biological Process	IMP[11912491]	7
GO:0000132	establishment of mitotic spindle orientation	Biological Process		7

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05130	Pathogenic Escherichia coli infection	17	Eenteropathogenic E. coli (EPEC) and enterohemorrhagic E. co...... Eenteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells. More...

Genes shared at least 5 GO terms with ARHGEF2 (count: 53)

Gene Symbol	Pathway Count	Pathway List
ARHGEF4	11	cytosol; apoptotic process; small GTPase mediated signal transduction; Rac guanyl-nucleotide exchange factor activity; ruffle membrane; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; phospholipid binding; Rho guanyl-nucleotide exchange factor activity; protein binding;
APC	10	tight junction; cytosol; negative regulation of microtubule depolymerization; apoptotic process; microtubule binding; ruffle membrane; negative regulation of apoptotic process; regulation of cytoskeleton organization; protein binding; microtubule cytoskeleton organization;
CLASP2	9	microtubule; cytosol; negative regulation of microtubule depolymerization; ruffle membrane; regulation of cytoskeleton organization; cell division; Golgi apparatus; protein binding; microtubule cytoskeleton organization;
MAPK1	9	spindle; cytosol; apoptotic process; transcription factor binding; small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; regulation of cytoskeleton organization; Golgi apparatus; protein binding;
ARHGEF12	9	cytosol; apoptotic process; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; phospholipid binding; Rho guanyl-nucleotide exchange factor activity; protein binding;
TRIO	9	cytosol; apoptotic process; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; phospholipid binding; Rho guanyl-nucleotide exchange factor activity; protein binding;
KATNB1	8	microtubule; negative regulation of microtubule depolymerization; microtubule binding; mitosis; neuronal cell body; regulation of cytoskeleton organization; cell division; microtubule cytoskeleton organization;
MAP1S	8	microtubule; spindle; cytosol; apoptotic process; microtubule binding; neuronal cell body; protein binding; microtubule cytoskeleton organization;
MAPRE1	8	microtubule; spindle; cytosol; regulation of cytoskeleton organization; cell division; Golgi apparatus; protein binding; microtubule cytoskeleton organization;
CLASP1	8	cytosol; negative regulation of microtubule depolymerization; microtubule binding; regulation of cytoskeleton organization; cell division; Golgi apparatus; protein binding; microtubule cytoskeleton organization;
FGD3	8	cytosol; apoptotic process; small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; phospholipid binding; Golgi apparatus; Rho guanyl-nucleotide exchange factor activity;
TIAM2	8	cytosol; apoptotic process; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; phospholipid binding; Rho guanyl-nucleotide exchange factor activity;
CDK5RAP2	7	microtubule; cytosol; microtubule binding; Golgi apparatus; protein binding; microtubule cytoskeleton organization; establishment of mitotic spindle orientation;
KIF11	7	microtubule; spindle; cytosol; microtubule binding; mitosis; cell division; microtubule cytoskeleton organization;
MAPT	7	microtubule; cytosol; apoptotic process; microtubule binding; regulation of cytoskeleton organization; protein binding; microtubule cytoskeleton organization;
ARHGEF17	7	cytosol; apoptotic process; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity;
MAPK3	7	cytosol; apoptotic process; small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; regulation of cytoskeleton organization; Golgi apparatus; protein binding;
MCF2L	7	cytosol; apoptotic process; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity;
NET1	7	cytosol; apoptotic process; small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; phospholipid binding; Rho guanyl-nucleotide exchange factor activity;
RELA	7	cytosol; transcription factor binding; negative regulation of apoptotic process; nerve growth factor receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; cellular response to tumor necrosis factor; protein binding;
SNCA	7	cytosol; microtubule binding; zinc ion binding; negative regulation of apoptotic process; phospholipid binding; Golgi apparatus; protein binding;
BIRC6	7	apoptotic process; mitosis; negative regulation of apoptotic process; regulation of cell proliferation; cell division; Golgi apparatus; protein binding;
HOOK3	6	microtubule; microtubule binding; negative regulation of neurogenesis; Golgi apparatus; protein binding; microtubule cytoskeleton organization;
KIF23	6	microtubule; spindle; cytosol; microtubule binding; protein binding; microtubule cytoskeleton organization;
NDE1	6	microtubule; cytosol; microtubule binding; cell division; protein binding; establishment of mitotic spindle orientation;
PLK1	6	spindle; cytosol; microtubule binding; mitosis; negative regulation of apoptotic process; protein binding;
ARAP1	6	cytosol; small GTPase mediated signal transduction; zinc ion binding; regulation of small GTPase mediated signal transduction; Golgi apparatus; protein binding;
BIRC2	6	cytosol; apoptotic process; zinc ion binding; negative regulation of apoptotic process; regulation of cell proliferation; protein binding;
CCDC88A	6	cytosol; microtubule binding; regulation of cell proliferation; regulation of cytoskeleton organization; Golgi apparatus; microtubule cytoskeleton organization;
GSK3B	6	cytosol; negative regulation of apoptotic process; neuronal cell body; nerve growth factor receptor signaling pathway; dendritic shaft; protein binding;
PAFAH1B1	6	cytosol; microtubule binding; neuronal cell body; protein binding; microtubule cytoskeleton organization; establishment of mitotic spindle orientation;
PRKD1	6	cytosol; apoptotic process; positive regulation of NF-kappaB transcription factor activity; phospholipid binding; Golgi apparatus; protein binding;
RAN	6	cytosol; mitosis; small GTPase mediated signal transduction; cell division; protein binding; microtubule cytoskeleton organization;
CENPJ	5	microtubule; cytosol; cell division; protein binding; microtubule cytoskeleton organization;
CEP57	5	microtubule; cytosol; microtubule binding; Golgi apparatus; protein binding;
MID1IP1	5	microtubule; cytosol; negative regulation of microtubule depolymerization; regulation of cytoskeleton organization; microtubule cytoskeleton organization;
NUMA1	5	spindle; cytosol; cell division; protein binding; establishment of mitotic spindle orientation;
PSRC1	5	spindle; cytosol; microtubule binding; cell division; protein binding;
BAD	5	cytosol; apoptotic process; nerve growth factor receptor signaling pathway; phospholipid binding; protein binding;
BCAR1	5	cytosol; actin filament organization; nerve growth factor receptor signaling pathway; cell division; protein binding;
CRYAB	5	cytosol; microtubule binding; negative regulation of apoptotic process; Golgi apparatus; protein binding;
KIF2C	5	cytosol; mitosis; cell division; protein binding; microtubule cytoskeleton organization;
LATS1	5	cytosol; mitosis; regulation of cytoskeleton organization; cell division; protein binding;
MAPK7	5	cytosol; apoptotic process; negative regulation of apoptotic process; nerve growth factor receptor signaling pathway; protein binding;
PRKCB	5	cytosol; apoptotic process; zinc ion binding; positive regulation of NF-kappaB transcription factor activity; protein binding;
SQSTM1	5	cytosol; apoptotic process; zinc ion binding; nerve growth factor receptor signaling pathway; protein binding;
TAX1BP1	5	cytosol; apoptotic process; zinc ion binding; negative regulation of apoptotic process; protein binding;
UBB	5	cytosol; apoptotic process; nerve growth factor receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; protein binding;
UBC	5	cytosol; apoptotic process; nerve growth factor receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; protein binding;
AATF	5	apoptotic process; negative regulation of apoptotic process; nerve growth factor receptor signaling pathway; Golgi apparatus; protein binding;
ARF6	5	apoptotic process; small GTPase mediated signal transduction; regulation of cytoskeleton organization; Golgi apparatus; protein binding;
GATA6	5	apoptotic process; transcription factor binding; zinc ion binding; negative regulation of apoptotic process; protein binding;
SPATA13	5	Rac guanyl-nucleotide exchange factor activity; ruffle membrane; regulation of Rho protein signal transduction; phospholipid binding; protein binding;

Genes shared at least 2 KEGG pathways with ARHGEF2 (count: 0)

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Region: chr1:155916630..155966129 View in gBrowse