ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ALDOA
Approved Name	aldolase A, fructose-bisphosphate
Location	16p11.2
Position	chr16:30064444-30081741, +
External Links	HGNC: 414 Entrez Gene: 226 Ensembl: ENSG00000149925 UCSC: uc002dvz.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 4)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_16	chr16:29563594-30367556 (NCBI Build 36.1 (hg18))	803963	16p11.2	Loss
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain
CNV_Jarick[2012]_35	chr16:29554843-30085308 (NCBI36 / hg18)	530466	16p11.2	del

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006096	glycolysis	Biological Process	IMP[14615364]	4
GO:0006094	gluconeogenesis	Biological Process		6
GO:0006006	glucose metabolic process	Biological Process		19
GO:0006000	fructose metabolic process	Biological Process	IMP[14615364]	4
GO:0007596	blood coagulation	Biological Process		83
GO:0007015	actin filament organization	Biological Process	TAS[1008835]	12
GO:0006941	striated muscle contraction	Biological Process	IMP[14615364]	4
GO:0006754	ATP biosynthetic process	Biological Process	IMP[14615364]	6
GO:0003779	actin binding	Molecular Function	TAS[1008835]	46
GO:0002576	platelet degranulation	Biological Process		12
GO:0005975	carbohydrate metabolic process	Biological Process		50
GO:0005829	cytosol	Cellular Component		447
GO:0005576	extracellular region	Cellular Component		240
GO:0004332	fructose-bisphosphate aldolase activity	Molecular Function	IDA[9244396]	2
GO:0042802	identical protein binding	Molecular Function	TAS[14766013]	70
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0046716	muscle cell homeostasis	Biological Process	IMP[14615364]	4
GO:0051289	protein homotetramerization	Biological Process		9
GO:0070061	fructose binding	Molecular Function	IDA[10048322]	2
GO:0070062	extracellular vesicular exosome	Cellular Component	IDA[17641064]	7
GO:0008092	cytoskeletal protein binding	Molecular Function	IDA[9244396]	11
GO:0008360	regulation of cell shape	Biological Process	IDA[9244396]	20
GO:0015629	actin cytoskeleton	Cellular Component	IDA[9244396]	26
GO:0015631	tubulin binding	Molecular Function	TAS[17329259]	9
GO:0030168	platelet activation	Biological Process		38
GO:0030388	fructose 1,6-bisphosphate metabolic process	Biological Process	IDA[9244396]	2
GO:0031093	platelet alpha granule lumen	Cellular Component		5
GO:0031674	I band	Cellular Component	TAS[1008835]	6

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00030	Pentose phosphate pathway	4	The pentose phosphate pathway is a process of glucose turnov...... The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008]. More...
hsa00051	Fructose and mannose metabolism	11
hsa00010	Glycolysis / Gluconeogenesis	11	Glycolysis is the process of converting glucose into pyruvat...... Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003]. More...

Genes shared at least 5 GO terms with ALDOA (count: 15)

Gene Symbol	Pathway Count	Pathway List
ALDOB	12	glycolysis; gluconeogenesis; glucose metabolic process; fructose metabolic process; carbohydrate metabolic process; cytosol; fructose-bisphosphate aldolase activity; identical protein binding; small molecule metabolic process; fructose binding; cytoskeletal protein binding; fructose 1,6-bisphosphate metabolic process;
FBP1	7	gluconeogenesis; glucose metabolic process; fructose metabolic process; carbohydrate metabolic process; cytosol; small molecule metabolic process; protein homotetramerization;
VEGFA	7	blood coagulation; platelet degranulation; extracellular region; identical protein binding; regulation of cell shape; platelet activation; platelet alpha granule lumen;
FBP2	6	gluconeogenesis; glucose metabolic process; fructose metabolic process; carbohydrate metabolic process; cytosol; small molecule metabolic process;
APOA1	6	blood coagulation; platelet degranulation; extracellular region; identical protein binding; small molecule metabolic process; platelet activation;
FN1	6	blood coagulation; platelet degranulation; extracellular region; regulation of cell shape; platelet activation; platelet alpha granule lumen;
WDR1	6	blood coagulation; actin binding; platelet degranulation; cytosol; extracellular region; platelet activation;
INPPL1	5	glucose metabolic process; actin filament organization; actin binding; cytosol; small molecule metabolic process;
CFL1	5	blood coagulation; actin filament organization; actin binding; platelet degranulation; platelet activation;
HABP4	5	blood coagulation; platelet degranulation; cytosol; extracellular region; platelet activation;
POTEKP	5	blood coagulation; platelet degranulation; cytosol; extracellular region; platelet activation;
SERPING1	5	blood coagulation; platelet degranulation; extracellular region; platelet activation; platelet alpha granule lumen;
TUBA4A	5	blood coagulation; platelet degranulation; cytosol; extracellular region; platelet activation;
VEGFB	5	blood coagulation; platelet degranulation; extracellular region; platelet activation; platelet alpha granule lumen;
GSN	5	actin binding; cytosol; extracellular region; extracellular vesicular exosome; actin cytoskeleton;

Genes shared at least 2 KEGG pathways with ALDOA (count: 14)

Gene Symbol	Pathway Count	Pathway List
ALDOB	4	Metabolic pathways; Pentose phosphate pathway; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis;
FBP1	4	Metabolic pathways; Pentose phosphate pathway; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis;
FBP2	4	Metabolic pathways; Pentose phosphate pathway; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis;
HK1	3	Metabolic pathways; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis;
HKDC1	3	Metabolic pathways; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis;
ALDH3A1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ALDH3A2	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ALDH3B1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ALDH3B2	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
DLAT	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
GMDS	2	Metabolic pathways; Fructose and mannose metabolism;
GMPPA	2	Metabolic pathways; Fructose and mannose metabolism;
SORD	2	Metabolic pathways; Fructose and mannose metabolism;
TSTA3	2	Metabolic pathways; Fructose and mannose metabolism;

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Region: chr16:30064444..30081741 View in gBrowse