ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CEP57
Symbol Alias	Translokin, TSP57, KIAA0092
Approved Name	centrosomal protein 57kDa
Location	11q21
Position	chr11:95523642-95565854, +
External Links	HGNC: 30794 Entrez Gene: 9702 Ensembl: ENSG00000166037 UCSC: uc001pfp.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0034453	microtubule anchoring	Biological Process		4
GO:0042803	protein homodimerization activity	Molecular Function	IPI[12717444]	113
GO:0043015	gamma-tubulin binding	Molecular Function		5
GO:0051260	protein homooligomerization	Biological Process		34
GO:0008017	microtubule binding	Molecular Function		32
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process	IPI[12717444]	26
GO:0015630	microtubule cytoskeleton	Cellular Component		34
GO:0017134	fibroblast growth factor binding	Molecular Function	IPI[12717444]	3
GO:0005737	cytoplasm	Cellular Component		690
GO:0005794	Golgi apparatus	Cellular Component	IDA[10942595]	157
GO:0005634	nucleus	Cellular Component	ISS[12954732]	770
GO:0005730	nucleolus	Cellular Component		243
GO:0005874	microtubule	Cellular Component	IDA[12717444]	52
GO:0007286	spermatid development	Biological Process	ISS[12954732]	11
GO:0005813	centrosome	Cellular Component		71
GO:0005829	cytosol	Cellular Component		447
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0005515	protein binding	Molecular Function		910
GO:0000060	protein import into nucleus, translocation	Biological Process	ISS[12717444]	5
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CEP57 (count: 85)

Gene Symbol	Pathway Count	Pathway List
PAFAH1B1	10	protein homodimerization activity; microtubule binding; cytoplasm; nucleus; nucleolus; centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
CRYAB	9	protein homodimerization activity; protein homooligomerization; microtubule binding; microtubule cytoskeleton; cytoplasm; Golgi apparatus; nucleus; cytosol; protein binding;
CDK5RAP2	9	microtubule binding; cytoplasm; Golgi apparatus; microtubule; centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
CLASP1	8	microtubule anchoring; microtubule binding; Golgi apparatus; centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
MAPK1	8	fibroblast growth factor receptor signaling pathway; microtubule cytoskeleton; cytoplasm; Golgi apparatus; nucleus; nucleolus; cytosol; protein binding;
CEP164	8	cytoplasm; nucleus; nucleolus; centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
MAPRE1	8	cytoplasm; Golgi apparatus; microtubule; centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
CLASP2	7	microtubule anchoring; cytoplasm; Golgi apparatus; microtubule; cytosol; mitotic cell cycle; protein binding;
TFAP2A	7	protein homodimerization activity; cytoplasm; Golgi apparatus; nucleus; nucleolus; centrosome; protein binding;
KIF23	7	microtubule binding; nucleus; microtubule; centrosome; cytosol; mitotic cell cycle; protein binding;
NDE1	7	microtubule binding; microtubule; centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
PLK1	7	microtubule binding; nucleus; centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
GSK3B	7	fibroblast growth factor receptor signaling pathway; cytoplasm; nucleus; nucleolus; centrosome; cytosol; protein binding;
MAPK3	7	fibroblast growth factor receptor signaling pathway; microtubule cytoskeleton; Golgi apparatus; nucleus; nucleolus; cytosol; protein binding;
NUMA1	7	cytoplasm; nucleus; nucleolus; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
TUBGCP2	7	nucleus; nucleolus; centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
DAXX	6	protein homodimerization activity; cytoplasm; nucleus; nucleolus; cytosol; protein binding;
PDE2A	6	protein homodimerization activity; cytoplasm; Golgi apparatus; nucleus; cytosol; protein binding;
TRIM5	6	protein homodimerization activity; cytoplasm; Golgi apparatus; nucleus; nucleolus; protein binding;
FEZ1	6	gamma-tubulin binding; microtubule cytoskeleton; cytoplasm; microtubule; centrosome; protein binding;
APC	6	microtubule binding; cytoplasm; nucleus; centrosome; cytosol; protein binding;
HOOK3	6	microtubule binding; cytoplasm; Golgi apparatus; microtubule; centrosome; protein binding;
PRC1	6	microtubule binding; microtubule cytoskeleton; cytoplasm; nucleus; nucleolus; protein binding;
SNCA	6	microtubule binding; cytoplasm; Golgi apparatus; nucleus; cytosol; protein binding;
TUBGCP5	6	microtubule binding; microtubule; centrosome; cytosol; mitotic cell cycle; G2/M transition of mitotic cell cycle;
TUBGCP6	6	microtubule binding; microtubule; centrosome; cytosol; mitotic cell cycle; G2/M transition of mitotic cell cycle;
PRKAR2B	6	fibroblast growth factor receptor signaling pathway; cytoplasm; centrosome; cytosol; mitotic cell cycle; G2/M transition of mitotic cell cycle;
ALKBH8	6	microtubule cytoskeleton; cytoplasm; nucleus; nucleolus; cytosol; protein binding;
CKAP5	6	microtubule cytoskeleton; centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
TUBGCP4	6	microtubule cytoskeleton; microtubule; centrosome; cytosol; mitotic cell cycle; G2/M transition of mitotic cell cycle;
AATF	6	cytoplasm; Golgi apparatus; nucleus; nucleolus; centrosome; protein binding;
RFWD2	6	cytoplasm; nucleus; nucleolus; centrosome; cytosol; protein binding;
SART1	6	cytoplasm; Golgi apparatus; nucleus; nucleolus; cytosol; protein binding;
TUBG1	6	cytoplasm; centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
CENPJ	6	microtubule; centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
GOPC	5	protein homodimerization activity; protein homooligomerization; cytoplasm; Golgi apparatus; protein binding;
MAP3K11	5	protein homodimerization activity; cytoplasm; microtubule; centrosome; protein binding;
MTMR2	5	protein homodimerization activity; cytoplasm; nucleus; cytosol; protein binding;
PYCARD	5	protein homodimerization activity; cytoplasm; nucleus; cytosol; protein binding;
RCHY1	5	protein homodimerization activity; cytoplasm; nucleus; nucleolus; protein binding;
RNF40	5	protein homodimerization activity; cytoplasm; nucleus; nucleolus; protein binding;
MARK4	5	gamma-tubulin binding; microtubule binding; microtubule cytoskeleton; centrosome; protein binding;
ARHGEF2	5	microtubule binding; Golgi apparatus; microtubule; cytosol; protein binding;
GABARAPL2	5	microtubule binding; cytoplasm; Golgi apparatus; cytosol; protein binding;
KATNB1	5	microtubule binding; microtubule cytoskeleton; cytoplasm; microtubule; centrosome;
MAP1S	5	microtubule binding; nucleus; microtubule; cytosol; protein binding;
PSRC1	5	microtubule binding; microtubule cytoskeleton; cytoplasm; cytosol; protein binding;
TPPP	5	microtubule binding; cytoplasm; nucleus; microtubule; protein binding;
UXT	5	microtubule binding; cytoplasm; nucleus; centrosome; protein binding;
CBL	5	fibroblast growth factor receptor signaling pathway; cytoplasm; nucleus; cytosol; protein binding;
DGCR8	5	microtubule cytoskeleton; cytoplasm; nucleus; nucleolus; protein binding;
KIF2C	5	microtubule cytoskeleton; nucleus; cytosol; mitotic cell cycle; protein binding;
TUBA4A	5	microtubule cytoskeleton; microtubule; cytosol; mitotic cell cycle; G2/M transition of mitotic cell cycle;
AIP	5	cytoplasm; nucleus; nucleolus; cytosol; protein binding;
ATXN2	5	cytoplasm; Golgi apparatus; nucleus; nucleolus; protein binding;
BAIAP2	5	cytoplasm; nucleus; nucleolus; cytosol; protein binding;
CDC45	5	cytoplasm; nucleus; centrosome; mitotic cell cycle; protein binding;
COG3	5	cytoplasm; Golgi apparatus; nucleus; nucleolus; protein binding;
DCPS	5	cytoplasm; nucleus; nucleolus; cytosol; protein binding;
DHX9	5	cytoplasm; nucleus; nucleolus; centrosome; protein binding;
FLII	5	cytoplasm; nucleus; nucleolus; centrosome; protein binding;
IARS	5	cytoplasm; nucleus; nucleolus; cytosol; protein binding;
ID2	5	cytoplasm; nucleus; nucleolus; cytosol; protein binding;
KLHL20	5	cytoplasm; Golgi apparatus; nucleus; nucleolus; protein binding;
MALT1	5	cytoplasm; nucleus; nucleolus; cytosol; protein binding;
MEN1	5	cytoplasm; nucleus; nucleolus; cytosol; protein binding;
PARK2	5	cytoplasm; Golgi apparatus; nucleus; cytosol; protein binding;
PDCD4	5	cytoplasm; nucleus; nucleolus; cytosol; protein binding;
POLA2	5	cytoplasm; nucleus; nucleolus; mitotic cell cycle; protein import into nucleus, translocation;
PPP1CA	5	cytoplasm; nucleus; nucleolus; cytosol; protein binding;
PRKD1	5	cytoplasm; Golgi apparatus; nucleus; cytosol; protein binding;
PSMC3	5	cytoplasm; nucleus; cytosol; mitotic cell cycle; protein binding;
PTTG1	5	cytoplasm; nucleus; cytosol; mitotic cell cycle; protein binding;
SMC1A	5	cytoplasm; nucleus; nucleolus; mitotic cell cycle; protein binding;
STXBP3	5	cytoplasm; nucleus; nucleolus; cytosol; protein binding;
TNFAIP3	5	cytoplasm; nucleus; centrosome; cytosol; protein binding;
WWOX	5	cytoplasm; Golgi apparatus; nucleus; cytosol; protein binding;
XPO1	5	cytoplasm; nucleolus; cytosol; mitotic cell cycle; protein binding;
COG5	5	Golgi apparatus; nucleus; nucleolus; cytosol; protein binding;
CHEK1	5	nucleus; centrosome; cytosol; protein binding; G2/M transition of mitotic cell cycle;
CSNK1E	5	nucleus; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
CEP250	5	centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
CEP76	5	centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
CNTRL	5	centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
DCTN3	5	centrosome; cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;

Genes shared at least 2 KEGG pathways with CEP57 (count: 0)

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Region: chr11:95523642..95565854 View in gBrowse