ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DCTN3
Symbol Alias	DCTN-22
Approved Name	dynactin 3 (p22)
Location	9p13
Position	chr9:34613548-34620496, -
External Links	HGNC: 2713 Entrez Gene: 11258 Ensembl: ENSG00000137100 UCSC: uc003zux.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 0)

LD-proxies (count: 2)

rs_ID	Location	Functional Annotation
rs3802427	Chr9:34618641(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs10814129	Chr9:34623718(Fwd)	intron_variant; splice_region_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005819	spindle	Cellular Component		29
GO:0005829	cytosol	Cellular Component		447
GO:0005515	protein binding	Molecular Function	IPI[9722614]	910
GO:0005813	centrosome	Cellular Component		71
GO:0000910	cytokinesis	Biological Process	IDA[9722614]	15
GO:0005198	structural molecule activity	Molecular Function	TAS[9722614]	29
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0000777	condensed chromosome kinetochore	Cellular Component		13
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA[9722614]	87
GO:0030496	midbody	Cellular Component		14
GO:0032154	cleavage furrow	Cellular Component		8
GO:0007067	mitosis	Biological Process		39
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Biological Process		14
GO:0005869	dynactin complex	Cellular Component	IPI[9722614]	1
GO:0007017	microtubule-based process	Biological Process		4
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DCTN3 (count: 22)

Gene Symbol	Pathway Count	Pathway List
PLK1	9	spindle; cytosol; protein binding; centrosome; cytokinesis; mitotic cell cycle; midbody; mitosis; G2/M transition of mitotic cell cycle;
KIF23	8	spindle; cytosol; protein binding; centrosome; cytokinesis; mitotic cell cycle; midbody; antigen processing and presentation of exogenous peptide antigen via MHC class II;
INCENP	7	spindle; cytosol; protein binding; cytokinesis; mitotic cell cycle; condensed chromosome kinetochore; midbody;
NDE1	7	cytosol; protein binding; centrosome; mitotic cell cycle; condensed chromosome kinetochore; cleavage furrow; G2/M transition of mitotic cell cycle;
PAFAH1B1	7	cytosol; protein binding; centrosome; mitotic cell cycle; perinuclear region of cytoplasm; microtubule-based process; G2/M transition of mitotic cell cycle;
MAPRE1	6	spindle; cytosol; protein binding; centrosome; mitotic cell cycle; G2/M transition of mitotic cell cycle;
NUMA1	6	spindle; cytosol; protein binding; structural molecule activity; mitotic cell cycle; G2/M transition of mitotic cell cycle;
CDK5RAP2	6	cytosol; protein binding; centrosome; mitotic cell cycle; perinuclear region of cytoplasm; G2/M transition of mitotic cell cycle;
CEP164	6	cytosol; protein binding; centrosome; mitotic cell cycle; mitosis; G2/M transition of mitotic cell cycle;
CEP250	6	cytosol; protein binding; centrosome; mitotic cell cycle; perinuclear region of cytoplasm; G2/M transition of mitotic cell cycle;
CLASP1	6	cytosol; protein binding; centrosome; mitotic cell cycle; condensed chromosome kinetochore; G2/M transition of mitotic cell cycle;
KIF2C	6	cytosol; protein binding; mitotic cell cycle; condensed chromosome kinetochore; mitosis; antigen processing and presentation of exogenous peptide antigen via MHC class II;
CDC25B	5	cytosol; centrosome; mitotic cell cycle; mitosis; G2/M transition of mitotic cell cycle;
CENPJ	5	cytosol; protein binding; centrosome; mitotic cell cycle; G2/M transition of mitotic cell cycle;
CEP57	5	cytosol; protein binding; centrosome; mitotic cell cycle; G2/M transition of mitotic cell cycle;
CEP76	5	cytosol; protein binding; centrosome; mitotic cell cycle; G2/M transition of mitotic cell cycle;
CKAP5	5	cytosol; protein binding; centrosome; mitotic cell cycle; G2/M transition of mitotic cell cycle;
CNTRL	5	cytosol; protein binding; centrosome; mitotic cell cycle; G2/M transition of mitotic cell cycle;
PRKAR2B	5	cytosol; centrosome; mitotic cell cycle; perinuclear region of cytoplasm; G2/M transition of mitotic cell cycle;
ROCK2	5	cytosol; protein binding; centrosome; cytokinesis; structural molecule activity;
TUBG1	5	cytosol; protein binding; centrosome; mitotic cell cycle; G2/M transition of mitotic cell cycle;
TUBGCP2	5	cytosol; protein binding; centrosome; mitotic cell cycle; G2/M transition of mitotic cell cycle;

Genes shared at least 2 KEGG pathways with DCTN3 (count: 0)

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Region: chr9:34613548..34620496 View in gBrowse