ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CENPJ
Previous Symbol	MCPH6
Symbol Alias	CPAP, BM032, LAP, LIP1, Sas-4, SASS4
Approved Name	centromere protein J
Previous Name	microcephaly, primary autosomal recessive 6
Location	13q12.12
Position	chr13:25456412-25497085, -
External Links	HGNC: 17272 Entrez Gene: 55835 Ensembl: ENSG00000151849 UCSC: uc001upt.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function	IPI[16713569]	910
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0005814	centriole	Cellular Component		11
GO:0005813	centrosome	Cellular Component		71
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29
GO:0046599	regulation of centriole replication	Biological Process		2
GO:0046785	microtubule polymerization	Biological Process	IMP[15047868]	2
GO:0051301	cell division	Biological Process	NAS[11003675]	58
GO:0008275	gamma-tubulin small complex	Cellular Component	NAS[11003675]	1
GO:0015631	tubulin binding	Molecular Function	IDA[15047868]	9
GO:0019901	protein kinase binding	Molecular Function		51
GO:0019904	protein domain specific binding	Molecular Function	IPI[11984006]	40
GO:0005829	cytosol	Cellular Component		447
GO:0005874	microtubule	Cellular Component		52
GO:0007020	microtubule nucleation	Biological Process	TAS[11003675]	8
GO:0007099	centriole replication	Biological Process	IMP[17681131]	1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CENPJ (count: 32)

Gene Symbol	Pathway Count	Pathway List
CDK5RAP2	9	protein binding; mitotic cell cycle; centrosome; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; tubulin binding; protein kinase binding; cytosol; microtubule;
NDE1	9	protein binding; mitotic cell cycle; centrosome; G2/M transition of mitotic cell cycle; cell division; protein domain specific binding; cytosol; microtubule; microtubule nucleation;
CLASP1	8	protein binding; mitotic cell cycle; centrosome; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; cell division; cytosol; microtubule nucleation;
MAPRE1	8	protein binding; mitotic cell cycle; centrosome; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; cell division; cytosol; microtubule;
CEP164	7	protein binding; mitotic cell cycle; centriole; centrosome; G2/M transition of mitotic cell cycle; cell division; cytosol;
CEP250	7	protein binding; mitotic cell cycle; centriole; centrosome; G2/M transition of mitotic cell cycle; protein kinase binding; cytosol;
CEP76	7	protein binding; mitotic cell cycle; centriole; centrosome; G2/M transition of mitotic cell cycle; regulation of centriole replication; cytosol;
CKAP5	7	protein binding; mitotic cell cycle; centrosome; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; cell division; cytosol;
CLASP2	7	protein binding; mitotic cell cycle; microtubule cytoskeleton organization; cell division; cytosol; microtubule; microtubule nucleation;
TUBGCP2	7	protein binding; mitotic cell cycle; centrosome; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; cytosol; microtubule nucleation;
TUBGCP5	7	mitotic cell cycle; centrosome; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; cytosol; microtubule; microtubule nucleation;
TUBGCP6	7	mitotic cell cycle; centrosome; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; cytosol; microtubule; microtubule nucleation;
CEP57	6	protein binding; mitotic cell cycle; centrosome; G2/M transition of mitotic cell cycle; cytosol; microtubule;
CNTRL	6	protein binding; mitotic cell cycle; centrosome; G2/M transition of mitotic cell cycle; cell division; cytosol;
KIF23	6	protein binding; mitotic cell cycle; centrosome; microtubule cytoskeleton organization; cytosol; microtubule;
PAFAH1B1	6	protein binding; mitotic cell cycle; centrosome; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; cytosol;
PLK1	6	protein binding; mitotic cell cycle; centrosome; G2/M transition of mitotic cell cycle; protein kinase binding; cytosol;
TUBG1	6	protein binding; mitotic cell cycle; centrosome; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; cytosol;
CDC25B	6	mitotic cell cycle; centrosome; G2/M transition of mitotic cell cycle; cell division; protein kinase binding; cytosol;
TUBGCP4	6	mitotic cell cycle; centrosome; G2/M transition of mitotic cell cycle; cytosol; microtubule; microtubule nucleation;
APC	5	protein binding; centrosome; microtubule cytoskeleton organization; protein kinase binding; cytosol;
ARHGEF2	5	protein binding; microtubule cytoskeleton organization; cell division; cytosol; microtubule;
CCND1	5	protein binding; mitotic cell cycle; cell division; protein kinase binding; cytosol;
DCTN3	5	protein binding; mitotic cell cycle; centrosome; G2/M transition of mitotic cell cycle; cytosol;
KIF2C	5	protein binding; mitotic cell cycle; microtubule cytoskeleton organization; cell division; cytosol;
LATS1	5	protein binding; G2/M transition of mitotic cell cycle; cell division; protein kinase binding; cytosol;
MAP1S	5	protein binding; microtubule cytoskeleton organization; tubulin binding; cytosol; microtubule;
MAPT	5	protein binding; microtubule cytoskeleton organization; protein kinase binding; cytosol; microtubule;
NUMA1	5	protein binding; mitotic cell cycle; G2/M transition of mitotic cell cycle; cell division; cytosol;
TPPP	5	protein binding; microtubule cytoskeleton organization; microtubule polymerization; tubulin binding; microtubule;
PRKAR2B	5	mitotic cell cycle; centrosome; G2/M transition of mitotic cell cycle; protein domain specific binding; cytosol;
KIF11	5	microtubule cytoskeleton organization; cell division; protein kinase binding; cytosol; microtubule;

Genes shared at least 2 KEGG pathways with CENPJ (count: 0)

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Region: chr13:25456412..25497085 View in gBrowse