ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MAPRE1
Symbol Alias	EB1
Approved Name	microtubule-associated protein, RP/EB family, member 1
Name Alias	adenomatous polyposis coli-binding protein EB1
Location	20q11.1-q11.3
Position	chr20:31407699-31438211, +
External Links	HGNC: 6890 Entrez Gene: 22919 Ensembl: ENSG00000101367 UCSC: uc002wyh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 23)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39
GO:0051493	regulation of cytoskeleton organization	Biological Process		32

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005829	cytosol	Cellular Component		447
GO:0005874	microtubule	Cellular Component	IDA[10773885]	52
GO:0005813	centrosome	Cellular Component		71
GO:0005819	spindle	Cellular Component	IDA[11943150]	29
GO:0005737	cytoplasm	Cellular Component		690
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0005515	protein binding	Molecular Function	IPI[19632184]	910
GO:0000236	mitotic prometaphase	Biological Process		17
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29
GO:0000087	M phase of mitotic cell cycle	Biological Process		19
GO:0051301	cell division	Biological Process		58
GO:0051010	microtubule plus-end binding	Molecular Function	IDA[19632184]	5
GO:0035372	protein localization to microtubule	Biological Process	IDA[19632184]	2
GO:0035371	microtubule plus end	Cellular Component		3
GO:0031253	cell projection membrane	Cellular Component		1
GO:0031115	negative regulation of microtubule polymerization	Biological Process	IDA[11943150]	3
GO:0030981	cortical microtubule cytoskeleton	Cellular Component	IDA[15631994]	2
GO:0008283	cell proliferation	Biological Process	TAS[7606712]	60
GO:0008022	protein C-terminus binding	Molecular Function	TAS[7606712]	32
GO:0005881	cytoplasmic microtubule	Cellular Component		8

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MAPRE1 (count: 50)

Gene Symbol	Pathway Count	Pathway List
CLASP1	14	cytosol; centrosome; Golgi apparatus; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; mitotic prometaphase; G2/M transition of mitotic cell cycle; M phase of mitotic cell cycle; regulation of cytoskeleton organization; cell division; microtubule plus-end binding; cortical microtubule cytoskeleton; cytoplasmic microtubule;
CLASP2	13	cytosol; microtubule; cytoplasm; Golgi apparatus; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; mitotic prometaphase; M phase of mitotic cell cycle; regulation of cytoskeleton organization; cell division; microtubule plus-end binding; cytoplasmic microtubule;
CKAP5	10	cytosol; centrosome; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; mitotic prometaphase; G2/M transition of mitotic cell cycle; M phase of mitotic cell cycle; cell division; microtubule plus end;
KIF2C	10	cytosol; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; mitotic prometaphase; M phase of mitotic cell cycle; cell division; microtubule plus-end binding; cell proliferation; cytoplasmic microtubule;
APC	9	cytosol; centrosome; cytoplasm; protein binding; microtubule cytoskeleton organization; regulation of cytoskeleton organization; microtubule plus-end binding; microtubule plus end; cytoplasmic microtubule;
CDK5RAP2	9	cytosol; microtubule; centrosome; cytoplasm; Golgi apparatus; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle;
NDE1	9	cytosol; microtubule; centrosome; mitotic cell cycle; protein binding; mitotic prometaphase; G2/M transition of mitotic cell cycle; M phase of mitotic cell cycle; cell division;
PAFAH1B1	9	cytosol; centrosome; cytoplasm; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; mitotic prometaphase; G2/M transition of mitotic cell cycle; M phase of mitotic cell cycle;
PLK1	9	cytosol; centrosome; spindle; mitotic cell cycle; protein binding; mitotic prometaphase; G2/M transition of mitotic cell cycle; M phase of mitotic cell cycle; cell proliferation;
ARHGEF2	8	cytosol; microtubule; spindle; Golgi apparatus; protein binding; microtubule cytoskeleton organization; regulation of cytoskeleton organization; cell division;
CENPJ	8	cytosol; microtubule; centrosome; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; cell division;
CEP57	8	cytosol; microtubule; centrosome; cytoplasm; Golgi apparatus; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
KIF23	8	cytosol; microtubule; centrosome; spindle; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; M phase of mitotic cell cycle;
CEP164	7	cytosol; centrosome; cytoplasm; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; cell division;
CEP250	7	cytosol; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; regulation of cytoskeleton organization; protein C-terminus binding;
INCENP	7	cytosol; microtubule; spindle; mitotic cell cycle; protein binding; mitotic prometaphase; M phase of mitotic cell cycle;
NUMA1	7	cytosol; spindle; cytoplasm; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; cell division;
TUBG1	7	cytosol; centrosome; cytoplasm; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle;
TUBGCP2	7	cytosol; centrosome; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; cytoplasmic microtubule;
SMC1A	7	cytoplasm; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; mitotic prometaphase; M phase of mitotic cell cycle; cell division;
SMC3	7	cytoplasm; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; mitotic prometaphase; M phase of mitotic cell cycle; cell division;
CENPC1	6	cytosol; cytoplasm; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle; cell division;
CNTRL	6	cytosol; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; cell division;
DCTN3	6	cytosol; centrosome; spindle; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
KIF11	6	cytosol; microtubule; spindle; cytoplasm; microtubule cytoskeleton organization; cell division;
MAPK1	6	cytosol; spindle; cytoplasm; Golgi apparatus; protein binding; regulation of cytoskeleton organization;
TUBGCP5	6	cytosol; microtubule; centrosome; mitotic cell cycle; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle;
TUBGCP6	6	cytosol; microtubule; centrosome; mitotic cell cycle; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle;
XPO1	6	cytosol; cytoplasm; mitotic cell cycle; protein binding; mitotic prometaphase; M phase of mitotic cell cycle;
ZW10	6	cytosol; mitotic cell cycle; protein binding; mitotic prometaphase; M phase of mitotic cell cycle; cell division;
HOOK3	6	microtubule; centrosome; cytoplasm; Golgi apparatus; protein binding; microtubule cytoskeleton organization;
KATNB1	6	microtubule; centrosome; cytoplasm; microtubule cytoskeleton organization; regulation of cytoskeleton organization; cell division;
BCAR1	5	cytosol; cytoplasm; protein binding; cell division; cell proliferation;
CDC25B	5	cytosol; centrosome; mitotic cell cycle; G2/M transition of mitotic cell cycle; cell division;
CEP76	5	cytosol; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
GSK3B	5	cytosol; centrosome; cytoplasm; protein binding; protein localization to microtubule;
LATS1	5	cytosol; protein binding; G2/M transition of mitotic cell cycle; regulation of cytoskeleton organization; cell division;
MAP1S	5	cytosol; microtubule; spindle; protein binding; microtubule cytoskeleton organization;
MAPT	5	cytosol; microtubule; protein binding; microtubule cytoskeleton organization; regulation of cytoskeleton organization;
MID1IP1	5	cytosol; microtubule; microtubule cytoskeleton organization; regulation of cytoskeleton organization; protein C-terminus binding;
PRKAR2B	5	cytosol; centrosome; cytoplasm; mitotic cell cycle; G2/M transition of mitotic cell cycle;
PRKD1	5	cytosol; cytoplasm; Golgi apparatus; protein binding; cell proliferation;
PSRC1	5	cytosol; spindle; cytoplasm; protein binding; cell division;
PTTG1	5	cytosol; cytoplasm; mitotic cell cycle; protein binding; cell division;
RAN	5	cytosol; cytoplasm; protein binding; microtubule cytoskeleton organization; cell division;
SKP2	5	cytosol; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; cell proliferation;
SNCA	5	cytosol; cytoplasm; Golgi apparatus; protein binding; negative regulation of microtubule polymerization;
TUBGCP4	5	cytosol; microtubule; centrosome; mitotic cell cycle; G2/M transition of mitotic cell cycle;
MAP3K11	5	microtubule; centrosome; cytoplasm; protein binding; cell proliferation;
SAC3D1	5	centrosome; spindle; cytoplasm; protein binding; cell division;

Genes shared at least 2 KEGG pathways with MAPRE1 (count: 0)

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Region: chr20:31407699..31438211 View in gBrowse