ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NUMA1
Approved Name	nuclear mitotic apparatus protein 1
Location	11q13
Position	chr11:71713911-71791573, -
External Links	HGNC: 8059 Entrez Gene: 4926 Ensembl: ENSG00000137497 UCSC: uc001orl.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000922	spindle pole	Cellular Component	IDA[14718566]	22
GO:0005198	structural molecule activity	Molecular Function	TAS[1541630]	29
GO:0000132	establishment of mitotic spindle orientation	Biological Process		7
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005694	chromosome	Cellular Component		15
GO:0005515	protein binding	Molecular Function	IPI[15537540]	910
GO:0005634	nucleus	Cellular Component		770
GO:0005819	spindle	Cellular Component	TAS[7004645]	29
GO:0005829	cytosol	Cellular Component		447
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component		690
GO:0016363	nuclear matrix	Cellular Component		16
GO:0045177	apical part of cell	Cellular Component		12
GO:0005876	spindle microtubule	Cellular Component	TAS[1541636]	9
GO:0006997	nucleus organization	Biological Process	TAS[1541630]	1
GO:0060487	lung epithelial cell differentiation	Biological Process		2
GO:0051301	cell division	Biological Process		58
GO:0000090	mitotic anaphase	Biological Process	TAS[1541636]	2
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NUMA1 (count: 92)

Gene Symbol	Pathway Count	Pathway List
PLK1	9	spindle pole; mitotic cell cycle; nucleoplasm; protein binding; nucleus; spindle; cytosol; spindle microtubule; G2/M transition of mitotic cell cycle;
SMC3	8	spindle pole; mitotic cell cycle; nucleoplasm; protein binding; nucleus; cytoplasm; nuclear matrix; cell division;
PAFAH1B1	8	establishment of mitotic spindle orientation; mitotic cell cycle; protein binding; nucleus; cytosol; nucleolus; cytoplasm; G2/M transition of mitotic cell cycle;
CEP164	8	mitotic cell cycle; protein binding; nucleus; cytosol; nucleolus; cytoplasm; cell division; G2/M transition of mitotic cell cycle;
CDK5RAP2	7	spindle pole; establishment of mitotic spindle orientation; mitotic cell cycle; protein binding; cytosol; cytoplasm; G2/M transition of mitotic cell cycle;
PRC1	7	spindle pole; protein binding; nucleus; spindle; nucleolus; cytoplasm; spindle microtubule;
PSRC1	7	spindle pole; protein binding; spindle; cytosol; cytoplasm; spindle microtubule; cell division;
TUBGCP2	7	spindle pole; mitotic cell cycle; protein binding; nucleus; cytosol; nucleolus; G2/M transition of mitotic cell cycle;
ZW10	7	spindle pole; establishment of mitotic spindle orientation; mitotic cell cycle; protein binding; nucleus; cytosol; cell division;
GPSM2	7	establishment of mitotic spindle orientation; protein binding; nucleus; nucleolus; cytoplasm; apical part of cell; lung epithelial cell differentiation;
ANAPC4	7	mitotic cell cycle; nucleoplasm; nucleus; cytosol; cell division; mitotic anaphase; G2/M transition of mitotic cell cycle;
CEP57	7	mitotic cell cycle; protein binding; nucleus; cytosol; nucleolus; cytoplasm; G2/M transition of mitotic cell cycle;
MAPRE1	7	mitotic cell cycle; protein binding; spindle; cytosol; cytoplasm; cell division; G2/M transition of mitotic cell cycle;
SMC1A	7	mitotic cell cycle; nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm; cell division;
MAPK1	7	nucleoplasm; protein binding; nucleus; spindle; cytosol; nucleolus; cytoplasm;
MEN1	7	nucleoplasm; protein binding; nucleus; cytosol; nucleolus; cytoplasm; nuclear matrix;
CDC25B	6	spindle pole; mitotic cell cycle; nucleoplasm; cytosol; cell division; G2/M transition of mitotic cell cycle;
CKAP5	6	spindle pole; mitotic cell cycle; protein binding; cytosol; cell division; G2/M transition of mitotic cell cycle;
KIF11	6	spindle pole; spindle; cytosol; cytoplasm; spindle microtubule; cell division;
DCTN3	6	structural molecule activity; mitotic cell cycle; protein binding; spindle; cytosol; G2/M transition of mitotic cell cycle;
NDE1	6	establishment of mitotic spindle orientation; mitotic cell cycle; protein binding; cytosol; cell division; G2/M transition of mitotic cell cycle;
CCND1	6	mitotic cell cycle; nucleoplasm; protein binding; nucleus; cytosol; cell division;
CLASP1	6	mitotic cell cycle; protein binding; cytosol; spindle microtubule; cell division; G2/M transition of mitotic cell cycle;
KIF23	6	mitotic cell cycle; nucleoplasm; protein binding; nucleus; spindle; cytosol;
PSMC3	6	mitotic cell cycle; nucleoplasm; protein binding; nucleus; cytosol; cytoplasm;
PTTG1	6	mitotic cell cycle; protein binding; nucleus; cytosol; cytoplasm; cell division;
XPO1	6	mitotic cell cycle; nucleoplasm; protein binding; cytosol; nucleolus; cytoplasm;
ATXN1	6	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm; nuclear matrix;
RCC1	6	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm; cell division;
RFWD2	6	nucleoplasm; protein binding; nucleus; cytosol; nucleolus; cytoplasm;
SART1	6	nucleoplasm; protein binding; nucleus; cytosol; nucleolus; cytoplasm;
SSRP1	6	nucleoplasm; chromosome; protein binding; nucleus; nucleolus; cytoplasm;
PPP1CA	6	protein binding; nucleus; cytosol; nucleolus; cytoplasm; cell division;
LATS1	5	spindle pole; protein binding; cytosol; cell division; G2/M transition of mitotic cell cycle;
LATS2	5	spindle pole; protein binding; nucleus; cytosol; cell division;
ARHGEF2	5	establishment of mitotic spindle orientation; protein binding; spindle; cytosol; cell division;
CDC26	5	mitotic cell cycle; nucleoplasm; protein binding; cytosol; cell division;
CDC45	5	mitotic cell cycle; nucleoplasm; protein binding; nucleus; cytoplasm;
CDT1	5	mitotic cell cycle; nucleoplasm; protein binding; nucleus; cytosol;
CENPC1	5	mitotic cell cycle; nucleus; cytosol; cytoplasm; cell division;
CENPJ	5	mitotic cell cycle; protein binding; cytosol; cell division; G2/M transition of mitotic cell cycle;
CENPW	5	mitotic cell cycle; protein binding; nucleolus; nuclear matrix; cell division;
CLASP2	5	mitotic cell cycle; protein binding; cytosol; cytoplasm; cell division;
CNTRL	5	mitotic cell cycle; protein binding; cytosol; cell division; G2/M transition of mitotic cell cycle;
CSNK1E	5	mitotic cell cycle; protein binding; nucleus; cytosol; G2/M transition of mitotic cell cycle;
FEN1	5	mitotic cell cycle; nucleoplasm; protein binding; nucleus; nucleolus;
KIF2C	5	mitotic cell cycle; protein binding; nucleus; cytosol; cell division;
POLA2	5	mitotic cell cycle; nucleoplasm; nucleus; nucleolus; cytoplasm;
POLD3	5	mitotic cell cycle; nucleoplasm; protein binding; nucleus; nucleolus;
RRM2	5	mitotic cell cycle; nucleoplasm; protein binding; cytosol; cytoplasm;
SKP2	5	mitotic cell cycle; nucleoplasm; protein binding; cytosol; G2/M transition of mitotic cell cycle;
TUBG1	5	mitotic cell cycle; protein binding; cytosol; cytoplasm; G2/M transition of mitotic cell cycle;
CHEK1	5	nucleoplasm; protein binding; nucleus; cytosol; G2/M transition of mitotic cell cycle;
DGCR8	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
DHX9	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
EFTUD2	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
EGLN3	5	nucleoplasm; protein binding; nucleus; cytosol; cytoplasm;
FANCC	5	nucleoplasm; protein binding; nucleus; cytosol; cytoplasm;
FUS	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
HNRNPA2B1	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
HNRNPH1	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
IRF7	5	nucleoplasm; protein binding; nucleus; cytosol; cytoplasm;
IRF9	5	nucleoplasm; protein binding; nucleus; cytosol; cytoplasm;
MAPK3	5	nucleoplasm; protein binding; nucleus; cytosol; nucleolus;
NCOR1	5	nucleoplasm; protein binding; nucleus; cytoplasm; spindle microtubule;
NEDD4L	5	nucleoplasm; protein binding; nucleus; cytosol; cytoplasm;
PGR	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
RAD23B	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
RAD9A	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
RAN	5	nucleoplasm; protein binding; cytosol; cytoplasm; cell division;
RBM4	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
RBPJ	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
RELA	5	nucleoplasm; protein binding; nucleus; cytosol; cytoplasm;
SNW1	5	nucleoplasm; protein binding; nucleus; nucleolus; nuclear matrix;
XRCC5	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
YAP1	5	nucleoplasm; protein binding; nucleus; cytosol; cytoplasm;
NUSAP1	5	chromosome; nucleus; nucleolus; cytoplasm; spindle microtubule;
ZFR	5	chromosome; protein binding; nucleus; nucleolus; cytoplasm;
AIP	5	protein binding; nucleus; cytosol; nucleolus; cytoplasm;
ALKBH8	5	protein binding; nucleus; cytosol; nucleolus; cytoplasm;
BAIAP2	5	protein binding; nucleus; cytosol; nucleolus; cytoplasm;
CDCA5	5	protein binding; nucleus; nucleolus; cytoplasm; cell division;
DAXX	5	protein binding; nucleus; cytosol; nucleolus; cytoplasm;
DCPS	5	protein binding; nucleus; cytosol; nucleolus; cytoplasm;
GSK3B	5	protein binding; nucleus; cytosol; nucleolus; cytoplasm;
IARS	5	protein binding; nucleus; cytosol; nucleolus; cytoplasm;
ID2	5	protein binding; nucleus; cytosol; nucleolus; cytoplasm;
MALT1	5	protein binding; nucleus; cytosol; nucleolus; cytoplasm;
PDCD4	5	protein binding; nucleus; cytosol; nucleolus; cytoplasm;
PSPC1	5	protein binding; nucleus; nucleolus; cytoplasm; nuclear matrix;
STXBP3	5	protein binding; nucleus; cytosol; nucleolus; cytoplasm;
TJP1	5	protein binding; nucleus; cytosol; cytoplasm; apical part of cell;

Genes shared at least 2 KEGG pathways with NUMA1 (count: 0)

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Region: chr11:71713911..71791573 View in gBrowse