ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NDE1
Symbol Alias	NUDE, FLJ20101
Approved Name	nudE nuclear distribution gene E homolog 1 (A. nidulans)
Location	16p13.11
Position	chr16:15737124-15820210, +
External Links	HGNC: 17619 Entrez Gene: 54820 Ensembl: ENSG00000072864 UCSC: uc002dds.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 9)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_20	chr16:15408600-16190572 (NCBI Build 36.1 (hg18))	788434	16p13.11	Gain
CNV_Williams[2010]_53	chr16:15387380-16197033 (NCBI Build 36.1 (hg18))	809654	16p13.11	Gain	De novo
CNV_Williams[2010]_23	chr16:15387380-16190572 (NCBI Build 36.1 (hg18))	797807	16p13.11	Gain
CNV_Williams[2010]_21	chr16:15156431-18174650 (NCBI Build 36.1 (hg18))	3006995	16p13.11-16p12.3	Gain
CNV_Williams[2010]_42	chr16:15387380-16197033 (NCBI Build 36.1 (hg18))	809654	16p13.11	Gain
CNV_Jarick[2012]_33	chr16:15387380-16197033 (NCBI36 / hg18)	809654	16p13.11	del
CNV_Jarick[2012]_32	chr16:15034391-16197033 (NCBI36 / hg18)	1162643	16p13.11	dup
CNV_Jarick[2012]_31	chr16:15032942-16197033 (NCBI36 / hg18)	1164092	16p13.11	del
CNV_Williams[2010]_4	chr16:15398985-18174650 (NCBI Build 36.1 (hg18))	2775666	16p13.11-16p12.3	Gain	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p13.11	chr16:14800000-16800000	1 (1/0/0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007020	microtubule nucleation	Biological Process		8
GO:0005874	microtubule	Cellular Component		52
GO:0008017	microtubule binding	Molecular Function		32
GO:0007405	neuroblast proliferation	Biological Process		2
GO:0021987	cerebral cortex development	Biological Process		11
GO:0019904	protein domain specific binding	Molecular Function		40
GO:0032154	cleavage furrow	Cellular Component		8
GO:0031616	spindle pole centrosome	Cellular Component		3
GO:0047496	vesicle transport along microtubule	Biological Process		2
GO:0042802	identical protein binding	Molecular Function		70
GO:0051301	cell division	Biological Process		58
GO:0051298	centrosome duplication	Biological Process		3
GO:0051303	establishment of chromosome localization	Biological Process	IMP[17600710]	1
GO:0000087	M phase of mitotic cell cycle	Biological Process		19
GO:0000132	establishment of mitotic spindle orientation	Biological Process	IMP[19468067]	7
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29
GO:0000776	kinetochore	Cellular Component	IDA[17600710]	15
GO:0000777	condensed chromosome kinetochore	Cellular Component		13
GO:0000236	mitotic prometaphase	Biological Process		17
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0005813	centrosome	Cellular Component		71
GO:0005829	cytosol	Cellular Component		447
GO:0001764	neuron migration	Biological Process		21
GO:0005515	protein binding	Molecular Function	IPI[16682949]	910

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NDE1 (count: 40)

Gene Symbol	Pathway Count	Pathway List
PAFAH1B1	14	microtubule binding; neuroblast proliferation; cerebral cortex development; vesicle transport along microtubule; M phase of mitotic cell cycle; establishment of mitotic spindle orientation; G2/M transition of mitotic cell cycle; kinetochore; mitotic prometaphase; mitotic cell cycle; centrosome; cytosol; neuron migration; protein binding;
CLASP1	12	microtubule nucleation; microtubule binding; cell division; M phase of mitotic cell cycle; G2/M transition of mitotic cell cycle; kinetochore; condensed chromosome kinetochore; mitotic prometaphase; mitotic cell cycle; centrosome; cytosol; protein binding;
CENPJ	9	microtubule nucleation; microtubule; protein domain specific binding; cell division; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol; protein binding;
CLASP2	9	microtubule nucleation; microtubule; cell division; M phase of mitotic cell cycle; condensed chromosome kinetochore; mitotic prometaphase; mitotic cell cycle; cytosol; protein binding;
MAPRE1	9	microtubule; cell division; M phase of mitotic cell cycle; G2/M transition of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle; centrosome; cytosol; protein binding;
PLK1	9	microtubule binding; M phase of mitotic cell cycle; G2/M transition of mitotic cell cycle; kinetochore; mitotic prometaphase; mitotic cell cycle; centrosome; cytosol; protein binding;
ZW10	9	cell division; M phase of mitotic cell cycle; establishment of mitotic spindle orientation; kinetochore; condensed chromosome kinetochore; mitotic prometaphase; mitotic cell cycle; cytosol; protein binding;
CDK5RAP2	8	microtubule; microtubule binding; establishment of mitotic spindle orientation; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol; protein binding;
INCENP	8	microtubule; M phase of mitotic cell cycle; kinetochore; condensed chromosome kinetochore; mitotic prometaphase; mitotic cell cycle; cytosol; protein binding;
CKAP5	8	cell division; M phase of mitotic cell cycle; G2/M transition of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle; centrosome; cytosol; protein binding;
KIF2C	8	cell division; M phase of mitotic cell cycle; kinetochore; condensed chromosome kinetochore; mitotic prometaphase; mitotic cell cycle; cytosol; protein binding;
TUBGCP5	7	microtubule nucleation; microtubule; microtubule binding; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol;
TUBGCP6	7	microtubule nucleation; microtubule; microtubule binding; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol;
CEP57	7	microtubule; microtubule binding; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol; protein binding;
KIF23	7	microtubule; microtubule binding; M phase of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol; protein binding;
XPO1	7	protein domain specific binding; M phase of mitotic cell cycle; kinetochore; mitotic prometaphase; mitotic cell cycle; cytosol; protein binding;
DCTN3	7	cleavage furrow; G2/M transition of mitotic cell cycle; condensed chromosome kinetochore; mitotic cell cycle; centrosome; cytosol; protein binding;
CENPC1	7	cell division; M phase of mitotic cell cycle; kinetochore; condensed chromosome kinetochore; mitotic prometaphase; mitotic cell cycle; cytosol;
SMC1A	7	cell division; M phase of mitotic cell cycle; kinetochore; condensed chromosome kinetochore; mitotic prometaphase; mitotic cell cycle; protein binding;
TUBGCP2	6	microtubule nucleation; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol; protein binding;
TUBGCP4	6	microtubule nucleation; microtubule; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol;
ARHGEF2	6	microtubule; microtubule binding; cell division; establishment of mitotic spindle orientation; cytosol; protein binding;
CEP250	6	spindle pole centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol; protein binding;
CEP164	6	cell division; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol; protein binding;
CNTRL	6	cell division; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol; protein binding;
NUMA1	6	cell division; establishment of mitotic spindle orientation; G2/M transition of mitotic cell cycle; mitotic cell cycle; cytosol; protein binding;
HOOK3	5	microtubule; microtubule binding; identical protein binding; centrosome; protein binding;
MAP1S	5	microtubule; microtubule binding; identical protein binding; cytosol; protein binding;
MAPT	5	microtubule; microtubule binding; cytosol; neuron migration; protein binding;
APC	5	microtubule binding; kinetochore; centrosome; cytosol; protein binding;
SNCA	5	microtubule binding; protein domain specific binding; identical protein binding; cytosol; protein binding;
PRKAR2B	5	protein domain specific binding; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol;
ROCK2	5	spindle pole centrosome; centrosome duplication; centrosome; cytosol; protein binding;
SKP2	5	identical protein binding; G2/M transition of mitotic cell cycle; mitotic cell cycle; cytosol; protein binding;
CDC25B	5	cell division; G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol;
CENPW	5	cell division; kinetochore; condensed chromosome kinetochore; mitotic cell cycle; protein binding;
SMC3	5	cell division; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle; protein binding;
CENPN	5	M phase of mitotic cell cycle; condensed chromosome kinetochore; mitotic prometaphase; mitotic cell cycle; cytosol;
CEP76	5	G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol; protein binding;
TUBG1	5	G2/M transition of mitotic cell cycle; mitotic cell cycle; centrosome; cytosol; protein binding;

Genes shared at least 2 KEGG pathways with NDE1 (count: 0)

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Region: chr16:15737124..15820210 View in gBrowse