ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HOOK3
Symbol Alias	HK3
Approved Name	hook homolog 3 (Drosophila)
Location	8p11.21
Position	chr8:42752033-42885682, +
External Links	HGNC: 23576 Entrez Gene: 84376 Ensembl: ENSG00000168172 UCSC: uc003xpr.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 25)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005737	cytoplasm	Cellular Component		690
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0000242	pericentriolar material	Cellular Component		2
GO:0005515	protein binding	Molecular Function	IPI[17237231]	910
GO:0015031	protein transport	Biological Process		75
GO:0008333	endosome to lysosome transport	Biological Process	IMP[18799622]	5
GO:0008017	microtubule binding	Molecular Function	IDA[11238449]	32
GO:0007040	lysosome organization	Biological Process	IMP[18799622]	7
GO:0007032	endosome organization	Biological Process	IMP[18799622]	7
GO:0005874	microtubule	Cellular Component		52
GO:0005813	centrosome	Cellular Component		71
GO:0005801	cis-Golgi network	Cellular Component	IDA[11238449]	14
GO:0050768	negative regulation of neurogenesis	Biological Process		3
GO:0045022	early endosome to late endosome transport	Biological Process	IMP[18799622]	3
GO:0042802	identical protein binding	Molecular Function	IPI[18799622]	70
GO:0034454	microtubule anchoring at centrosome	Biological Process		1
GO:0034451	centriolar satellite	Cellular Component		4
GO:0031122	cytoplasmic microtubule organization	Biological Process	IMP[11238449]	3
GO:0030897	HOPS complex	Cellular Component	IDA[18799622]	3
GO:0022027	interkinetic nuclear migration	Biological Process		2
GO:0051645	Golgi localization	Biological Process	IMP[11238449]	1
GO:0070695	FHF complex	Cellular Component	IDA[18799622]	2
GO:0071539	protein localization to centrosome	Biological Process		1
GO:0097150	neuronal stem cell maintenance	Biological Process		2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HOOK3 (count: 19)

Gene Symbol	Pathway Count	Pathway List
CDK5RAP2	8	cytoplasm; Golgi apparatus; pericentriolar material; protein binding; microtubule cytoskeleton organization; microtubule binding; microtubule; centrosome;
FAM160A2	7	protein binding; protein transport; endosome to lysosome transport; lysosome organization; endosome organization; early endosome to late endosome transport; FHF complex;
APC	6	cytoplasm; protein binding; microtubule cytoskeleton organization; microtubule binding; centrosome; cytoplasmic microtubule organization;
CEP57	6	cytoplasm; Golgi apparatus; protein binding; microtubule binding; microtubule; centrosome;
MAPRE1	6	cytoplasm; Golgi apparatus; protein binding; microtubule cytoskeleton organization; microtubule; centrosome;
ARHGEF2	6	Golgi apparatus; protein binding; microtubule cytoskeleton organization; microtubule binding; microtubule; negative regulation of neurogenesis;
CLASP2	5	cytoplasm; Golgi apparatus; protein binding; microtubule cytoskeleton organization; microtubule;
GABARAPL2	5	cytoplasm; Golgi apparatus; protein binding; protein transport; microtubule binding;
KATNB1	5	cytoplasm; microtubule cytoskeleton organization; microtubule binding; microtubule; centrosome;
MAP3K11	5	cytoplasm; protein binding; microtubule; centrosome; identical protein binding;
PAFAH1B1	5	cytoplasm; protein binding; microtubule cytoskeleton organization; microtubule binding; centrosome;
PRC1	5	cytoplasm; protein binding; microtubule cytoskeleton organization; microtubule binding; identical protein binding;
SNCA	5	cytoplasm; Golgi apparatus; protein binding; microtubule binding; identical protein binding;
TPPP	5	cytoplasm; protein binding; microtubule cytoskeleton organization; microtubule binding; microtubule;
UXT	5	cytoplasm; protein binding; microtubule cytoskeleton organization; microtubule binding; centrosome;
CLASP1	5	Golgi apparatus; protein binding; microtubule cytoskeleton organization; microtubule binding; centrosome;
KIF23	5	protein binding; microtubule cytoskeleton organization; microtubule binding; microtubule; centrosome;
MAP1S	5	protein binding; microtubule cytoskeleton organization; microtubule binding; microtubule; identical protein binding;
NDE1	5	protein binding; microtubule binding; microtubule; centrosome; identical protein binding;

Genes shared at least 2 KEGG pathways with HOOK3 (count: 0)

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Region: chr8:42752033..42885682 View in gBrowse