ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CLASP2
Symbol Alias	KIAA0627
Approved Name	cytoplasmic linker associated protein 2
Location	3p24.3
Position	chr3:33537737-33759848, -
External Links	HGNC: 17078 Entrez Gene: 23122 Ensembl: ENSG00000163539 UCSC: uc003cfu.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by PBA pathway

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Trend

Gene related SNPs (count: 25)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs9844608	Chr3:33774574(Fwd)		1(0/0/1)

LD-proxies (count: 24)

rs_ID	Location	Functional Annotation
rs4287875	Chr3:33763296(Fwd)	upstream_gene_variant
rs4437091	Chr3:33756889(Fwd)	intron_variant; nc_transcript_variant
rs7641020	Chr3:33751018(Fwd)	intron_variant; nc_transcript_variant
rs6770784	Chr3:33734606(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs6550229	Chr3:33732592(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs4679073	Chr3:33689633(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs9849641	Chr3:33613376(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs12106734	Chr3:33600112(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs7643855	Chr3:33605300(Fwd)	intron_variant; upstream_gene_variant
rs6774696	Chr3:33608875(Fwd)	downstream_gene_variant; intron_variant
rs9839042	Chr3:33745827(Fwd)	intron_variant; nc_transcript_variant
rs4328759	Chr3:33602907(Fwd)	intron_variant; upstream_gene_variant
rs9840630	Chr3:33740736(Fwd)	intron_variant; nc_transcript_variant
rs9856967	Chr3:33648715(Fwd)	downstream_gene_variant; intron_variant
rs7624319	Chr3:33737093(Fwd)	intron_variant; nc_transcript_variant
rs9847845	Chr3:33699640(Fwd)	intron_variant; nc_transcript_variant
rs4450748	Chr3:33711482(Fwd)	intron_variant
rs9809240	Chr3:33665652(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs9853831	Chr3:33693794(Fwd)	intron_variant; nc_transcript_variant
rs9311020	Chr3:33636869(Fwd)	intron_variant
rs6807732	Chr3:33653803(Fwd)	intron_variant
rs6550225	Chr3:33616881(Fwd)	intron_variant; nc_transcript_variant
rs9867080	Chr3:33620305(Fwd)	intron_variant; upstream_gene_variant
rs9817358	Chr3:33630663(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 29)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39
GO:0051493	regulation of cytoskeleton organization	Biological Process		32

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	Cellular Component		772
GO:0005881	cytoplasmic microtubule	Cellular Component	IDA[11290329]	8
GO:0005874	microtubule	Cellular Component		52
GO:0005829	cytosol	Cellular Component		447
GO:0007163	establishment or maintenance of cell polarity	Biological Process	TAS[15928712]	5
GO:0007026	negative regulation of microtubule depolymerization	Biological Process	NAS[11290329]	7
GO:0007020	microtubule nucleation	Biological Process	IMP[17543864]	8
GO:0005938	cell cortex	Cellular Component	IDA[17113391]	26
GO:0005737	cytoplasm	Cellular Component	NAS[11290329]	690
GO:0005515	protein binding	Molecular Function	IPI[11290329]	910
GO:0000777	condensed chromosome kinetochore	Cellular Component		13
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0005828	kinetochore microtubule	Cellular Component	TAS[12837247]	3
GO:0005815	microtubule organizing center	Cellular Component		19
GO:0005802	trans-Golgi network	Cellular Component	IDA[17543864]	28
GO:0005794	Golgi apparatus	Cellular Component	IDA[11290329]	157
GO:0000236	mitotic prometaphase	Biological Process		17
GO:0000087	M phase of mitotic cell cycle	Biological Process		19
GO:0051301	cell division	Biological Process		58
GO:0032587	ruffle membrane	Cellular Component		12
GO:0032886	regulation of microtubule-based process	Biological Process		5
GO:0034453	microtubule anchoring	Biological Process	IMP[17543864]	4
GO:0051010	microtubule plus-end binding	Molecular Function	IDA[19632184]	5
GO:0007411	axon guidance	Biological Process		65
GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity	Molecular Function	NAS[11290329]	1
GO:0031023	microtubule organizing center organization	Biological Process	IMP[17543864]	3
GO:0031110	regulation of microtubule polymerization or depolymerization	Biological Process	IMP[11290329]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CLASP2 (count: 58)

Gene Symbol	Pathway Count	Pathway List
CLASP1	20	cytoplasmic microtubule; cytosol; establishment or maintenance of cell polarity; negative regulation of microtubule depolymerization; microtubule nucleation; cell cortex; protein binding; condensed chromosome kinetochore; mitotic cell cycle; kinetochore microtubule; Golgi apparatus; microtubule cytoskeleton organization; mitotic prometaphase; M phase of mitotic cell cycle; cell division; regulation of cytoskeleton organization; microtubule anchoring; microtubule plus-end binding; axon guidance; microtubule organizing center organization;
MAPRE1	13	cytoplasmic microtubule; microtubule; cytosol; cytoplasm; protein binding; mitotic cell cycle; Golgi apparatus; microtubule cytoskeleton organization; mitotic prometaphase; M phase of mitotic cell cycle; cell division; regulation of cytoskeleton organization; microtubule plus-end binding;
APC	11	plasma membrane; cytoplasmic microtubule; cytosol; negative regulation of microtubule depolymerization; cytoplasm; protein binding; microtubule cytoskeleton organization; regulation of cytoskeleton organization; ruffle membrane; regulation of microtubule-based process; microtubule plus-end binding;
KIF2C	10	cytoplasmic microtubule; cytosol; protein binding; condensed chromosome kinetochore; mitotic cell cycle; microtubule cytoskeleton organization; mitotic prometaphase; M phase of mitotic cell cycle; cell division; microtubule plus-end binding;
ARHGEF2	9	microtubule; cytosol; negative regulation of microtubule depolymerization; protein binding; Golgi apparatus; microtubule cytoskeleton organization; cell division; regulation of cytoskeleton organization; ruffle membrane;
NDE1	9	microtubule; cytosol; microtubule nucleation; protein binding; condensed chromosome kinetochore; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle; cell division;
PAFAH1B1	9	cytosol; cell cortex; cytoplasm; protein binding; mitotic cell cycle; microtubule cytoskeleton organization; mitotic prometaphase; M phase of mitotic cell cycle; microtubule organizing center organization;
ZW10	8	cytosol; protein binding; condensed chromosome kinetochore; mitotic cell cycle; kinetochore microtubule; mitotic prometaphase; M phase of mitotic cell cycle; cell division;
SMC1A	8	cytoplasm; protein binding; condensed chromosome kinetochore; mitotic cell cycle; microtubule cytoskeleton organization; mitotic prometaphase; M phase of mitotic cell cycle; cell division;
KATNB1	7	plasma membrane; microtubule; negative regulation of microtubule depolymerization; cytoplasm; microtubule cytoskeleton organization; cell division; regulation of cytoskeleton organization;
PRKD1	7	plasma membrane; cytosol; cell cortex; cytoplasm; protein binding; trans-Golgi network; Golgi apparatus;
TUBGCP2	7	cytoplasmic microtubule; cytosol; microtubule nucleation; protein binding; mitotic cell cycle; microtubule organizing center; microtubule cytoskeleton organization;
CDK5RAP2	7	microtubule; cytosol; cytoplasm; protein binding; mitotic cell cycle; Golgi apparatus; microtubule cytoskeleton organization;
CENPJ	7	microtubule; cytosol; microtubule nucleation; protein binding; mitotic cell cycle; microtubule cytoskeleton organization; cell division;
CEP57	7	microtubule; cytosol; cytoplasm; protein binding; mitotic cell cycle; Golgi apparatus; microtubule anchoring;
INCENP	7	microtubule; cytosol; protein binding; condensed chromosome kinetochore; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
CENPC1	7	cytosol; cytoplasm; condensed chromosome kinetochore; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle; cell division;
CKAP5	7	cytosol; protein binding; mitotic cell cycle; microtubule cytoskeleton organization; mitotic prometaphase; M phase of mitotic cell cycle; cell division;
MAPK1	7	cytosol; cytoplasm; protein binding; microtubule organizing center; Golgi apparatus; regulation of cytoskeleton organization; axon guidance;
SMC3	7	cytoplasm; protein binding; mitotic cell cycle; microtubule cytoskeleton organization; mitotic prometaphase; M phase of mitotic cell cycle; cell division;
GSK3B	6	plasma membrane; cytosol; cytoplasm; protein binding; regulation of microtubule-based process; axon guidance;
MAPT	6	plasma membrane; microtubule; cytosol; protein binding; microtubule cytoskeleton organization; regulation of cytoskeleton organization;
NCK1	6	plasma membrane; cytosol; cytoplasm; protein binding; regulation of cytoskeleton organization; axon guidance;
PAK1	6	plasma membrane; cytosol; cytoplasm; protein binding; Golgi apparatus; axon guidance;
SNCA	6	plasma membrane; cytosol; cell cortex; cytoplasm; protein binding; Golgi apparatus;
KIF23	6	microtubule; cytosol; protein binding; mitotic cell cycle; microtubule cytoskeleton organization; M phase of mitotic cell cycle;
XPO1	6	cytosol; cytoplasm; protein binding; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
ARF6	5	plasma membrane; cell cortex; protein binding; Golgi apparatus; regulation of cytoskeleton organization;
BCAR1	5	plasma membrane; cytosol; cytoplasm; protein binding; cell division;
CCDC88A	5	plasma membrane; cytosol; Golgi apparatus; microtubule cytoskeleton organization; regulation of cytoskeleton organization;
CRYAB	5	plasma membrane; cytosol; cytoplasm; protein binding; Golgi apparatus;
FEZ1	5	plasma membrane; microtubule; cytoplasm; protein binding; axon guidance;
GOLPH3	5	plasma membrane; cytosol; cytoplasm; protein binding; trans-Golgi network;
INPPL1	5	plasma membrane; cytosol; cytoplasm; protein binding; Golgi apparatus;
NF2	5	plasma membrane; cytoplasm; protein binding; regulation of cytoskeleton organization; ruffle membrane;
PDE2A	5	plasma membrane; cytosol; cytoplasm; protein binding; Golgi apparatus;
PRKG1	5	plasma membrane; cytosol; cytoplasm; protein binding; Golgi apparatus;
TPPP	5	plasma membrane; microtubule; cytoplasm; protein binding; microtubule cytoskeleton organization;
WWOX	5	plasma membrane; cytosol; cytoplasm; protein binding; Golgi apparatus;
YES1	5	plasma membrane; cytosol; cytoplasm; microtubule organizing center; Golgi apparatus;
HOOK3	5	microtubule; cytoplasm; protein binding; Golgi apparatus; microtubule cytoskeleton organization;
KIF11	5	microtubule; cytosol; cytoplasm; microtubule cytoskeleton organization; cell division;
MID1IP1	5	microtubule; cytosol; negative regulation of microtubule depolymerization; microtubule cytoskeleton organization; regulation of cytoskeleton organization;
TUBGCP5	5	microtubule; cytosol; microtubule nucleation; mitotic cell cycle; microtubule cytoskeleton organization;
TUBGCP6	5	microtubule; cytosol; microtubule nucleation; mitotic cell cycle; microtubule cytoskeleton organization;
CENPN	5	cytosol; condensed chromosome kinetochore; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
CEP164	5	cytosol; cytoplasm; protein binding; mitotic cell cycle; cell division;
CEP250	5	cytosol; protein binding; mitotic cell cycle; microtubule organizing center; regulation of cytoskeleton organization;
LATS1	5	cytosol; protein binding; microtubule organizing center; cell division; regulation of cytoskeleton organization;
MAPK3	5	cytosol; protein binding; Golgi apparatus; regulation of cytoskeleton organization; axon guidance;
NCK2	5	cytosol; cytoplasm; protein binding; regulation of cytoskeleton organization; axon guidance;
NUMA1	5	cytosol; cytoplasm; protein binding; mitotic cell cycle; cell division;
PLK1	5	cytosol; protein binding; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
PTTG1	5	cytosol; cytoplasm; protein binding; mitotic cell cycle; cell division;
RAN	5	cytosol; cytoplasm; protein binding; microtubule cytoskeleton organization; cell division;
TSC1	5	cytosol; cell cortex; cytoplasm; protein binding; regulation of cytoskeleton organization;
TUBG1	5	cytosol; cytoplasm; protein binding; mitotic cell cycle; microtubule cytoskeleton organization;
BIRC6	5	protein binding; microtubule organizing center; trans-Golgi network; Golgi apparatus; cell division;

Genes shared at least 2 KEGG pathways with CLASP2 (count: 0)

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Region: chr3:33537737..33759848 View in gBrowse