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- Data Summary
Gene Report
Approved Symbol | ADRA2C |
---|---|
Previous Symbol | ADRA2L2, ADRA2RL2 |
Symbol Alias | ADRARL2 |
Approved Name | adrenergic, alpha-2C-, receptor |
Location | 4p16.3 |
Position | chr4:3768075-3770253, + |
External Links |
HGNC: 283 Entrez Gene: 152 Ensembl: ENSG00000184160 UCSC: uc003ghm.2 |
No. of Studies | 7 (significant: 2; non-significant: 4; trend: 1) |
Source | Literature-origin; Mapped by literature SNP |
Reference | Statistical Values/Author Comments | Result of Statistical Analysis |
---|---|---|
Feng J, 2001 | C444T was found to occur in ADHD patients in this mutational analysis | Trend |
De Luca V, 2004 (b) | no preferential transmission of any allele of microsatellite polymorphism in ADRA2C | Non-significant |
Barr CL, 2001(c) | there was no evidence for biased transmission of any of the alleles of the ADRA2C polymorphism | Non-significant |
Guan L, 2009 | 1 SNP in this gene achieved significance for ADHD and ADHD-C in single SNP association analysis. | Significant |
Brookes K, 2006 | UNPHASED TDT P-value=0.496, global P-value=0.942, WHAP TDT P_sum P-value=0.972, no SNP with nominal P-value<0.05 located in this gene | Non-significant |
Hawi, Z., 2012 | This gene did not show significant association with ADHD. | Non-significant |
Cho SC, 2008(a) | ADRA2C(GT)n repeat polymorphism is involved in the etiology of ADHD | Significant |
Literature-origin SNPs (count: 2)
rs_ID | Location | Functional Annotation | No. of Studies (significant/non-significant/trend) |
---|---|---|---|
rs7678463 | Chr4:3770952(Fwd) | downstream_gene_variant | 1(0/1/0) |
rs7682295 | Chr4:3765225(Fwd) | upstream_gene_variant | 1(1/0/0) |
LD-proxies (count: 0)
Variant Name | Variant Type | Location in Gene | No. of Studies (significant/non-significant/trend) |
---|---|---|---|
ADRA2C_C444T | point mutation | 1 (0/0/1) | |
ADRA2C_upstream_(TG)n | microsatellite | upstream | 3 (1/2/0) |
GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)
GO terms by database search (count: 28)
ID | Name | No. of Genes in ADHDgene | Brief Description |
---|---|---|---|
hsa04080 | Neuroactive ligand-receptor interaction | 93 |
Region: chr4:3768075..3770253 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014