ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CCKAR
Approved Name	cholecystokinin A receptor
Location	4
Position	chr4:26483018-26492084, -
External Links	HGNC: 1570 Entrez Gene: 886 Ensembl: ENSG00000163394 UCSC: uc003gse.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_18	chr4:23596065-27014659 (NCBI Build 36.1 (hg18))	3365040	4p15.2	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	Cellular Component		772
GO:0004951	cholecystokinin receptor activity	Molecular Function		2
GO:0001764	neuron migration	Biological Process		21
GO:0030900	forebrain development	Biological Process		9
GO:0007631	feeding behavior	Biological Process	TAS[8503909]	9
GO:0007586	digestion	Biological Process	TAS[8503909]	13
GO:0007584	response to nutrient	Biological Process	TAS[8503909]	15
GO:0007409	axonogenesis	Biological Process		14
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process	TAS[8503909]	20
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	Biological Process	TAS[8343165]	12
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8343165]	220

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04972	Pancreatic secretion	30	The pancreas performs both exocrine and endocrine functions....... The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion. More...
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with CCKAR (count: 1)

Gene Symbol	Pathway Count	Pathway List
CCKBR	7	plasma membrane; cholecystokinin receptor activity; feeding behavior; digestion; elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway; integral to plasma membrane;

Genes shared at least 2 KEGG pathways with CCKAR (count: 40)

Gene Symbol	Pathway Count	Pathway List
CHRM3	3	Neuroactive ligand-receptor interaction; Pancreatic secretion; Calcium signaling pathway;
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
SCTR	2	Neuroactive ligand-receptor interaction; Pancreatic secretion;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADCY4	2	Pancreatic secretion; Calcium signaling pathway;
ATP2B3	2	Pancreatic secretion; Calcium signaling pathway;
ITPR1	2	Pancreatic secretion; Calcium signaling pathway;
ITPR2	2	Pancreatic secretion; Calcium signaling pathway;
PLCB2	2	Pancreatic secretion; Calcium signaling pathway;
PLCB3	2	Pancreatic secretion; Calcium signaling pathway;
PRKCB	2	Pancreatic secretion; Calcium signaling pathway;
RYR2	2	Pancreatic secretion; Calcium signaling pathway;
TRPC1	2	Pancreatic secretion; Calcium signaling pathway;

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Region: chr4:26483018..26492084 View in gBrowse