ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HOXA1
Previous Symbol	HOX1F, HOX1
Approved Name	homeobox A1
Previous Name	homeo box A1
Location	7p15.2
Position	chr7:27132612-27135625, -
External Links	HGNC: 5099 Entrez Gene: 3198 Ensembl: ENSG00000105991 UCSC: uc003sye.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
7p15	chr7:20900000-28800000	2 (1/1/0)

Gene related GO terms (count: 30)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0090102	cochlea development	Biological Process	IMP[16155570]	5
GO:0090103	cochlea morphogenesis	Biological Process	IMP[16155570]	2
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component		770
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0009653	anatomical structure morphogenesis	Biological Process	IMP[16155570]	26
GO:0009952	anterior/posterior pattern specification	Biological Process		26
GO:0021569	rhombomere 3 development	Biological Process		1
GO:0021570	rhombomere 4 development	Biological Process		2
GO:0007275	multicellular organismal development	Biological Process	TAS[7622051]	71
GO:0007605	sensory perception of sound	Biological Process	IDA[16155570]	31
GO:0007634	optokinetic behavior	Biological Process	IDA[16155570]	1
GO:0008045	motor neuron axon guidance	Biological Process		7
GO:0042473	outer ear morphogenesis	Biological Process	IDA[16155570]	2
GO:0021953	central nervous system neuron differentiation	Biological Process		1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0021599	abducens nerve formation	Biological Process	IMP[16155570]	1
GO:0021571	rhombomere 5 development	Biological Process		2
GO:0021754	facial nucleus development	Biological Process		2
GO:0021612	facial nerve structural organization	Biological Process		2
GO:0050905	neuromuscular process	Biological Process	IDA[16155570]	2
GO:0050890	cognition	Biological Process	IDA[16155570]	6
GO:0060876	semicircular canal formation	Biological Process	IMP[16155570]	1
GO:0060840	artery development	Biological Process	IMP[16155570]	2
GO:0048839	inner ear development	Biological Process	IMP[16155570]	5
GO:0048702	embryonic neurocranium morphogenesis	Biological Process	IMP[16155570]	1
GO:0050795	regulation of behavior	Biological Process	IDA[16155570]	3
GO:0048844	artery morphogenesis	Biological Process	IMP[16155570]	9

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HOXA1 (count: 42)

Gene Symbol	Pathway Count	Pathway List
HOXB1	11	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; rhombomere 4 development; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; rhombomere 5 development; facial nucleus development; facial nerve structural organization;
TBX1	10	cochlea morphogenesis; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sensory perception of sound; outer ear morphogenesis; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; artery morphogenesis;
HES1	7	cochlea development; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; artery morphogenesis;
HOXA13	7	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; inner ear development; artery morphogenesis;
HOXA2	7	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; motor neuron axon guidance; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA5	7	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA9	7	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; multicellular organismal development; sequence-specific DNA binding;
HEY2	6	cochlea development; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
ETS1	6	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HNF1B	6	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; anterior/posterior pattern specification; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA10	6	sequence-specific DNA binding transcription factor activity; protein binding; transcription, DNA-dependent; anterior/posterior pattern specification; multicellular organismal development; sequence-specific DNA binding;
HOXA11	6	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; anatomical structure morphogenesis; anterior/posterior pattern specification; multicellular organismal development; sequence-specific DNA binding;
HOXA4	6	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anatomical structure morphogenesis; anterior/posterior pattern specification; sequence-specific DNA binding;
HOXA7	6	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
LHX1	6	sequence-specific DNA binding transcription factor activity; nucleus; anatomical structure morphogenesis; anterior/posterior pattern specification; motor neuron axon guidance; sequence-specific DNA binding;
LMX1B	6	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; multicellular organismal development; sequence-specific DNA binding;
POU2F3	6	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
SREBF1	6	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
ATF6	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
BATF2	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
BSX	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
CREBZF	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
FOXC2	5	sequence-specific DNA binding transcription factor activity; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; artery morphogenesis;
FOXD4	5	sequence-specific DNA binding transcription factor activity; nucleus; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
FOXE1	5	sequence-specific DNA binding transcription factor activity; nucleus; anatomical structure morphogenesis; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HIRA	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; anatomical structure morphogenesis;
HOXA3	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding;
HOXA6	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding;
IKZF1	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
KDM1A	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
LHX2	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
MAF	5	sequence-specific DNA binding transcription factor activity; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; inner ear development;
MEIS2	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
MTA2	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
NCOR1	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
ONECUT2	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
RELA	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
TSHZ2	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; multicellular organismal development; sequence-specific DNA binding;
ZNF24	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
MEN1	5	protein binding; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
NR4A2	5	protein binding; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
TFAP2A	5	protein binding; nucleus; sensory perception of sound; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;

Genes shared at least 2 KEGG pathways with HOXA1 (count: 0)

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Region: chr7:27132612..27135625 View in gBrowse